Drugs / Escitalopram
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Escitalopram

Small molecule targets CYP2D6, SLC6A4 via inhibition

Developed for
major depressive disorder · depressive disorder · anxiety · dysthymic disorder · obsessive-compulsive disorder · generalized anxiety disorder · schizophrenia · anxiety disorder
+61 more · post-traumatic stress disorder · Alzheimer disease · stroke disorder · bipolar disorder · coronary artery disorder · dementia · epilepsy · irritable bowel syndrome · postpartum depression · bipolar depression · borderline personality disorder · eating disorder · insomnia · ischemic stroke · multiple sclerosis · somatoform disorder · spinal cord injury · type 2 diabetes mellitus · alcohol dependence · aphasia · atypical depressive disorder · autism spectrum disorder · bipolar I disorder · bipolar II disorder · brain glioma · chronic obstructive pulmonary disease · chronic pain syndrome · cocaine dependence · cognitive impairment with or without cerebellar ataxia · dyspepsia · fibromyalgia · impulse control disorder · mental disorder · myocardial ischemia · overactive bladder · panic disorder · phobic disorder · polyneuropathy · premature ejaculation · premenstrual tension · rheumatoid arthritis · sleep disorder · social phobia · substance dependence · agoraphobia · asthma · burning mouth syndrome · cancer · cannabis dependence · chronic rhinosinusitis · cocaine abuse · end stage renal failure · melancholia · metastatic neoplasm · mixed anxiety and depressive disorder · neurological pain disorder · polycystic ovary syndrome · premature menopause · psychotic disorder · pulmonary hypertension · separation anxiety disorder
Investigated by
Forest Laboratories · National Institute of Mental Health (NIMH) · H. Lundbeck A/S · Massachusetts General Hospital · New York State Psychiatric Institute · Duke University
+230 more · University of Pennsylvania · Weill Medical College of Cornell University · University of Pittsburgh · Emory University · Otsuka Pharmaceutical Development & Commercialization, Inc. · Seoul National University Hospital · Indiana University · Peking University · Sheba Medical Center · BeerYaakov Mental Health Center · Eli Lilly and Company · Hoffmann-La Roche · Lundbeck Israel · Medical University of Vienna · Rigshospitalet, Denmark · Samsung Medical Center · Shirley Ryan AbilityLab · University of Cincinnati · Xian-Janssen Pharmaceutical Ltd. · AstraZeneca · Cairo University · Centre for Addiction and Mental Health · Dr. Inge Winter · First Hospital of China Medical University · GlaxoSmithKline · Hadassah Medical Organization · Johns Hopkins University · Lundbeck Foundation · Max-Planck-Institute of Psychiatry · Mayo Clinic · Mylan Pharmaceuticals Inc · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Nova Scotia Health Authority · Oregon Health and Science University · Seoul National University Bundang Hospital · Shanghai Mental Health Center · Stanford University · The First Hospital of Hebei Medical University · University Health Network, Toronto · University of Cambridge · University of Minnesota · University of Münster · University of Nebraska · University of Ottawa · University of Rochester · University of Sao Paulo · University of South Carolina · University of Southern Denmark · Wake Forest University Health Sciences · Washington University School of Medicine · Aarhus University Hospital · Abarbanel Mental Health Center · AbbVie · Academy of Finland · Ajay Wasan, MD, Msc · All India Institute of Medical Sciences, Bhopal · Amager Hospital · Amsterdam UMC, location VUmc · Asan Medical Center · Augusta University · Azienda Ospedaliero Universitaria Maggiore della Carita · BC Women's Hospital & Health Centre · Beitou Armed Forces Hospital, Taipei, Taiwan · Bispebjerg Hospital · Brigham and Women's Hospital · Bristol-Myers Squibb · Bronx VA Medical Center · Burke Medical Research Institute · Cantonal Hospital of St. Gallen · Capital Medical University · Case Comprehensive Cancer Center · Cedars-Sinai Medical Center · Center for Integrated Molecular Brain Imaging, Copenhagen, Denmak · all 236 on the full record

Regulatory milestones approvals, filings & regulatory actions · 5 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (4) US (FDA) LEXAPRO 2002-08-29 – 2023-05-12 fda.gov
Approved US (FDA) LEXAPRO 2002-08-14 fda.gov

Trials 245 · started per year

today
US approved 2002
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2001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT06796946 Jun → Dec 2026 expected University of Huelva Not yet recruiting No outcome recorded
Phase 0 NCT03623711 Aug 2018 → Dec 2022 major depressive disorder Yuqi Cheng Unknown No outcome recorded
Phase 0 NCT00656552 May → Dec 2008 premature ejaculation Cairo University Unknown No outcome recorded
Phase 123 trials
Phase 1 NCT07139834 Jun 2026 → Jun 2027 expected major depressive disorder Jeffrey Miller Recruiting No outcome recorded
Phase 1 NCT06680531 Aug → Sep 2024 insomnia Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Completed No outcome recorded
Phase 1 NCT04836533 Jan 2023 depressive disorder Queens College, The City University of New York Withdrawn No outcome recorded
Phase 1 NCT05470465 Sep 2022 → Sep 2023 respiratory underresponsiveness to hypoxia and hypercapnia Food and Drug Administration (FDA) Completed No outcome recorded
Phase 1 NCT02869035 Aug 2016 → Jul 2019 major depressive disorder Rigshospitalet, Denmark Completed No outcome recorded
Phase 1 NCT02175602 Jun → Aug 2014 hepatitis C virus infection Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02122939 Sep 2013 → Mar 2014 Seoul National University Hospital Completed No outcome recorded
Phase 1 NCT01871701 Nov 2012 → May 2014 Seoul National University Hospital Completed No outcome recorded
Phase 1 NCT01753882 Feb 2012 → Jul 2020 spinal cord injury Shirley Ryan AbilityLab Unknown No outcome recorded
Phase 1 NCT01418274 Aug → Sep 2011 Hoffmann-La Roche Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06696482 Jan → Sep 2025 overdue University of Oxford Not yet recruiting No outcome recorded
Phase 1/2 NCT04221256 Mar 2020 → Feb 2021 ischemic stroke Burke Medical Research Institute Withdrawn No outcome recorded
Phase 225 trials
Phase 2 NCT06705478 May → Dec 2026 HIV infectious disease, cognitive disorder, major depressive disorder National Institute of Allergy and Infectious Diseases (NIAID) Suspended No outcome recorded
Phase 2 NCT06826326 Apr 2025 → Dec 2026 expected autism spectrum disorder Kathryn Unruh Enrolling by invitation No outcome recorded
Phase 2 NCT05536414 Sep 2022 → May 2025 major depressive disorder Otsuka Pharmaceutical Development & Commercialization, Inc. Completed No outcome recorded
Phase 2 NCT05289830 Aug 2022 → Aug 2023 pancreatic ductal adenocarcinoma, periampullary adenocarcinoma Case Comprehensive Cancer Center Terminated No outcome recorded
Phase 2 NCT05002309 Dec 2021 → Jun 2028 expected major depressive disorder Nova Scotia Health Authority Recruiting No outcome recorded
Phase 2 NCT03843463 Jul 2021 → Sep 2026 expected aphasia, stroke disorder Johns Hopkins University Recruiting No outcome recorded
Phase 2 NCT04437485 Oct 2020 → Aug 2022 dysthymic disorder, major depressive disorder, prediabetes syndrome, type 2 diabetes mellitus Indiana University Completed No outcome recorded
Phase 2 NCT03728673 Mar 2019 → Jun 2027 expected brain glioma University of Nebraska Recruiting No outcome recorded
Phase 2 NCT03222570 Feb 2018 → Apr 2024 depressive disorder University of Minnesota Completed No outcome recorded
Phase 2 NCT03527043 Oct 2017 → Apr 2023 spermatogenic failure Weill Medical College of Cornell University Terminated No outcome recorded
Phase 2/312 trials
Phase 2/3 NCT05519683 Nov 2022 → Sep 2026 expected irritable bowel syndrome University of Michigan Recruiting No outcome recorded
Phase 2/3 NCT04747314 Mar 2021 → Nov 2024 anxiety, chronic pain syndrome Ajay Wasan, MD, Msc Completed No outcome recorded
Phase 2/3 NCT03487211 Apr 2018 → Feb 2020 fibromyalgia Shaheed Zulfiqar Ali Bhutto Medical University Completed No outcome recorded
Phase 2/3 NCT02623231 Dec 2015 → Dec 2017 depressive disorder, glioblastoma Tel-Aviv Sourasky Medical Center Unknown No outcome recorded
Phase 2/3 NCT00866593 Mar 2009 → Mar 2010 depressive disorder Shanghai Mental Health Center Completed No outcome recorded
Phase 2/3 NCT00767624 Dec 2008 → Jun 2015 major depressive disorder, sleep disorder, initiating and maintaining sleep Stanford University Completed No outcome recorded
Phase 2/3 NCT00732901 Jun 2008 → Feb 2013 cocaine dependence Virginia Commonwealth University Completed No outcome recorded
Phase 2/3 NCT01876823 Apr 2006 → Mar 2010 Alzheimer disease, cognitive impairment with or without cerebellar ataxia, major depressive disorder New York State Psychiatric Institute Completed No outcome recorded
Phase 2/3 NCT00655057 Oct 2005 → Aug 2009 depressive disorder University of Pennsylvania Completed No outcome recorded
Phase 2/3 NCT00215228 Jul 2005 → Aug 2007 major depressive disorder Duke University Completed No outcome recorded
Phase 335 trials
Phase 3 NCT05603104 Apr 2025 → Jun 2028 expected bipolar depression, major depressive disorder, schizophrenia Dr. Inge Winter Recruiting No outcome recorded
Phase 3 NCT05973786 Feb 2025 → Jun 2028 expected bipolar depression Dr. Inge Winter Recruiting No outcome recorded
Phase 3 NCT06153004 Aug 2023 → Mar 2024 depressive disorder Harvard Medical School (HMS and HSDM) Completed No outcome recorded
Phase 3 NCT05480878 Dec 2022 → Mar 2023 rheumatoid arthritis Tanta University Completed No outcome recorded
Phase 3 NCT05950061 Jun → Oct 2022 major depressive disorder KRL Hospital, Islamabad Completed No outcome recorded
Phase 3 NCT02532660 Jul 2018 → Jun 2022 depressive disorder Laboratório Catarinense SA Terminated No outcome recorded
Phase 3 NCT03108846 Jan 2018 → Apr 2024 overdue dementia JHSPH Center for Clinical Trials Active not recruiting No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT02153567 Dec 2013 → Dec 2018 anxiety, depressive disorder, dyspepsia Chinese University of Hong Kong Completed No outcome recorded
Phase 3 NCT00488670 Dec 2010 → Jun 2011 depressive disorder University of British Columbia Terminated No outcome recorded
Phase 4104 trials
Phase 4 NCT07432815 Feb → Dec 2026 expected anxiety, depressive disorder, psoriasis Cairo University Recruiting No outcome recorded
Phase 4 NCT07488910 Feb 2026 → Jan 2028 expected major depressive disorder Goethe University Not yet recruiting No outcome recorded
Phase 4 NCT06433635 Oct 2024 → Feb 2030 expected bipolar I disorder, depressive disorder Massachusetts General Hospital Active not recruiting No outcome recorded
Phase 4 NCT04623099 Mar 2021 → Jun 2026 overdue anxiety University of Cincinnati Recruiting No outcome recorded
Phase 4 NCT04697693 Mar → May 2021 major depressive disorder, post-traumatic stress disorder New York State Psychiatric Institute Terminated No outcome recorded
Phase 4 NCT04239339 Apr 2020 → Oct 2022 Rigshospitalet, Denmark Completed No outcome recorded
Phase 4 NCT04336228 Apr 2020 → Dec 2027 expected obsessive-compulsive disorder Rigshospitalet, Denmark Active not recruiting No outcome recorded
Phase 4 NCT05145270 Nov 2019 → Nov 2022 major depressive disorder Shanghai Mental Health Center Unknown No outcome recorded
Phase 4 NCT03993457 Jul 2019 → Mar 2022 depressive disorder University of Texas Southwestern Medical Center Terminated No outcome recorded
Phase 4 NCT03924323 May 2019 → Sep 2021 generalized anxiety disorder AbbVie Completed No outcome recorded
Phase not applicable41 trials
NCT07480525 Mar → Dec 2026 expected major depressive disorder Peking University Not yet recruiting No outcome recorded
NCT06001021 Aug → Sep 2023 mental disorder Sameera Shafiq Completed No outcome recorded
NCT05389046 Aug 2022 → Dec 2024 Peking University Unknown No outcome recorded
NCT05480150 Nov 2021 → Dec 2026 expected bipolar disorder, major depressive disorder First Affiliated Hospital of Zhejiang University Recruiting No outcome recorded
NCT03841474 Mar → Jun 2021 coronary artery disorder, depressive disorder University Hospital Centre Zagreb Unknown No outcome recorded
NCT04478526 Apr 2020 → May 2021 generalized anxiety disorder Dr. Nazanin Alavi Completed No outcome recorded
NCT07074652 Dec 2017 → Jun 2022 anxiety UCLH/UCL Joint Research Office Completed No outcome recorded
NCT03148522 Jun 2017 → Dec 2021 Peking University Unknown No outcome recorded
NCT04013464 May 2016 → May 2018 major depressive disorder Peking University Sixth Hospital Completed No outcome recorded
NCT02516332 Dec 2015 → May 2020 anxiety, cardiovascular disorder Duke University Completed No outcome recorded
Also used as a comparator or background therapy in 205 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03887624 Background May 2019 → Apr 2021 major depressive disorder Zhejiang University Completed No outcome recorded
Phase 17 trials
Phase 1 NCT06965569 Background Apr → Dec 2025 Alar Pharmaceuticals Inc. Completed No outcome recorded
Phase 1 NCT06476509 Comparator May 2024 → Jan 2025 major depressive disorder Vigonvita Life Sciences Completed No outcome recorded
Phase 1 NCT03912974 Comparator Jul 2019 → Nov 2020 University Hospital, Basel, Switzerland Completed No outcome recorded
Phase 1 NCT02072278 Comparator Feb → Nov 2014 H. Lundbeck A/S Completed No outcome recorded
Phase 1 NCT01601730 Comparator Aug 2010 → Jul 2011 cocaine abuse, cocaine dependence Baylor College of Medicine Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT04410341 Background May 2020 → Dec 2024 major depressive disorder Sadat City University Withdrawn No outcome recorded
Phase 1/2 NCT03323697 Comparator Aug 2017 → Sep 2018 mixed anxiety and depressive disorder Mazra Mental Health Center Unknown No outcome recorded
Phase 1/2 NCT00135421 Comparator Nov 2005 → Oct 2007 major depressive disorder Bristol-Myers Squibb Completed No outcome recorded
Phase 219 trials
Phase 2 NCT06216535 Comparator May 2025 → Dec 2028 expected asthma University of Texas Southwestern Medical Center Recruiting No outcome recorded
Phase 2 NCT06828887 Comparator Apr 2025 → Sep 2026 expected major depressive disorder Vigonvita Life Sciences Recruiting No outcome recorded
Phase 2 NCT03429075 Comparator Jan 2019 → Apr 2020 major depressive disorder Imperial College London Completed No outcome recorded
Phase 2 NCT03388164 Comparator Jan 2018 → May 2019 depressive disorder Laureate Institute for Brain Research, Inc. Terminated No outcome recorded
Phase 2 NCT03321526 Background Dec 2017 → Jun 2019 major depressive disorder Janssen Research & Development, LLC Completed No outcome recorded
Phase 2/37 trials
Phase 2/3 NCT03909217 Comparator Jul 2019 → Jul 2021 major depressive disorder The University of Hong Kong Completed No outcome recorded
Phase 2/3 NCT02674529 Comparator Sep 2016 → May 2021 major depressive disorder Marta Peciña, MD PhD Completed No outcome recorded
Phase 2/3 NCT01219686 Comparator Oct 2010 → Apr 2013 major depressive disorder Markus KOSEL Terminated No outcome recorded
Phase 2/3 NCT00481325 Comparator Jul 2007 → Mar 2008 generalized anxiety disorder Bristol-Myers Squibb Completed No outcome recorded
Phase 2/3 NCT00248651 Comparator Oct 2006 → Jul 2013 dyspepsia Mayo Clinic Completed No outcome recorded
Phase 344 trials
Phase 3 NCT06025474 Comparator Jan → Oct 2023 burning mouth syndrome Federico II University Unknown No outcome recorded
Phase 3 NCT04973930 Comparator Mar 2022 → Dec 2025 breast cancer, major depressive disorder New York State Psychiatric Institute Suspended No outcome recorded
Phase 3 NCT04763135 Comparator Dec 2021 cancer, metastatic neoplasm Hospices Civils de Lyon Terminated No outcome recorded
Phase 3 NCT03652870 Comparator Mar 2021 → Jan 2023 Parkinson disease, depressive disorder University College, London Completed No outcome recorded
Phase 3 NCT04598230 Comparator Feb 2021 → Aug 2025 overdue generalized anxiety disorder, separation anxiety disorder, social phobia Ann & Robert H Lurie Children's Hospital of Chicago Active not recruiting No outcome recorded
Phase 471 trials
Phase 4 NCT07478796 Comparator Apr 2025 → Nov 2027 expected major depressive disorder Poznan University of Medical Sciences Recruiting No outcome recorded
Phase 4 NCT05737511 Comparator Dec 2023 → Dec 2026 expected panic disorder Sultan Qaboos University Not yet recruiting No outcome recorded
Phase 4 NCT07590609 Background May 2023 → Jan 2026 major depressive disorder Peking University Sixth Hospital Completed No outcome recorded
Phase 4 NCT05017311 Comparator Jan 2023 → Dec 2028 expected major depressive disorder Nova Scotia Health Authority Recruiting No outcome recorded
Phase 4 NCT06675851 Comparator Dec 2022 → Dec 2026 expected major depressive disorder Medical University of Vienna Recruiting No outcome recorded
Phase not applicable53 trials
NCT07331987 Background Jun → Dec 2026 expected mixed anxiety and depressive disorder Moon (Guangzhou) Biotechnology Co., Ltd. Recruiting No outcome recorded
NCT07645807 Background Jun 2026 → Jan 2027 expected Sichuan Credit Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
NCT06937476 Background May 2025 → Apr 2026 overdue major depressive disorder, rumination disorder Central South University Active not recruiting No outcome recorded
NCT06957223 Comparator May → Nov 2025 major depressive disorder Asad Ullah Jan Completed No outcome recorded
NCT07025590 Comparator Apr 2025 → Dec 2026 expected cardiovascular disorder, mixed anxiety and depressive disorder Guangdong Provincial People's Hospital Recruiting No outcome recorded

Press releases naming this drug 3 releases

DateIssuerRelease
2014-06-18 Takeda Results of a New Study of Brintellix ® (vortioxetine) vs. Escitalopram on Sexual Functioning in Well Treated MDD Patients Experiencing Treatment-Emergent Sexual Dysfunction takeda.com
2012-03-14 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Launch of Generic Lexapro® in the United States; Awarded 180-Day Period of Marketing Exclusivity tevapharm.com
2006-05-22 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Approval of Generic Lexapro® Tablets tevapharm.com

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 456 sources stand behind the page.

FieldValueCited text
Known as escitalopram “The proposed study will consist of a double-blinded, randomized controlled trial using a crossover design to assess the effects of SSRIs (escitalopram oxalate, Lexapro®, Forest...” NCT01788969
434

“we have restricted the IMPACT list of antidepressants to SSRIs (sertraline, escitalopram, paroxetine, fluoxetine, citalopram), duloxetine, bupropion, and mirtazapine. These...” NCT02458690

“Participants receive only clinical routine antidepressant treatment,Which include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa)...” NCT01831440

“Antidepressant medications may include the following: citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil CR), sertraline (Zoloft), venlafaxine XR (Effexor XR),...” NCT00564278

“Medication group is a control group that can choose to use the serotonin reuptake inhibitors (SSRIs) approved by China food and Drug Administration (SFDA) for the treatment of...” NCT03558256

“In cases of intolerance or adverse reaction to fluoxetine, the investigator will switch to sertraline (25 to 200mg) or escitalopram (5 to 20mg), the other two antidepressants...” NCT05002309

“ADT such as citalopram, escitalopram, fluoxetine, sertraline, paroxetine, vilazodone, venlafaxine, desvenlafaxine, duloxetine or bupropion prescribed in accordance with its...” NCT01838876

“Eligible adults (18-65 years) were assigned to antidepressant monotherapy (escitalopram or venlafaxine extended-release) plus lisdexamfetamine dimesylate-matching placebo...” PMID 28857719 Aug 2017

“SSRI (paxil CR, es-citalopram, fluoxetine, sertraline) start with (paxil CR 12.5mg, es-citalopram 10mg, fluoxetine 20mg, sertraline 50mg) for 1 week up to maximal dosage,...” NCT01357967

“Drug: Antidepressant (citalopram, duloxetine, escitalopram, sertraline, or venlafaxine XR) + cariprazine (0.1-0.3 mg/d) Oral, once daily for 8 weeks following an 8 week...” NCT00854100

“Selective Serotonin Reuptake Inhibitor (Escitalopram, 5-10 mg in pregnancy and Sertraline, 12.5-25 mg in postpartum) and/or Benzodiazepine (Alprazolam, 0.25-0.5 mg) will be...” NCT06001021

“SPD489 20mg, 30mg, 50mg, or 70mg + Antidepressant (either escitalopram oxalate, sertraline hydrochloride, venlafaxine hydrochloride extended release or duloxetine...” NCT01436175

“The dose is 20-60mg/day for fluoxetine, 20-40mg/day for paroxetine, 100-300mg/day for fluvoxamine, 50-200mg/day for sertraline, 20-40mg/day for citalopram, 10-20mg/day for...” NCT05148169

“Participants will receive SSRI antidepressant (such as, citalopram, escitalopram, fluvoxamine, fluoxetine, paroxetine, sertraline, vilazodone or vortioxetine) as a part of...” NCT03321526

“If never taken SSRI or SNRI, commence primary medication arm (SSRI: sertraline, escitalopram or Pregabalin/SNRI: duloxetine, venlafaxine) will be described to patient and will...” NCT04478526

“Antidepressant medications may include any of the following: citalopram, escitalopram, paroxetine, sertraline, venlafaxine XR, bupropion SR, duloxetine, nortriptyline, and mirtazapine.” NCT00742573

“approved by the State Food and Drug Administration (CFDA) for the treatment of OCD (i.e., fluoxetine, paroxetine, sertraline and fluvoxamine) as well as citalopram and escitalopramNCT05528224

“This study uses SSRIs class drugs, including fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram, and escitalopram, with no specific restrictions on the type of drugs.” NCT06358014

“Patients assigned to the low expectancy condition will be told they will receive either placebo or escitalopram when in fact they will receive escitalopram for eight weeks.” NCT04836533

“We made other SSRIs (escitalopram, sertraline) and SNRIs (desvenlafaxine, duloxetine, venlafaxine) our third-line antidepressants, given their negligible effects on weight.” NCT04437485

“ADT such as bupropion, citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, sertraline, venlafaxine, paroxetine or vilazodone as prescribed by the physician.” NCT01715805

“Antidepressant (either escitalopram oxalate, sertraline hydrochloride, venlafaxine hydrochloride extended release or duloxetine hydrochloride) oral, once daily” NCT01436162

“If patient has a history of non-response or cannot tolerate escitalopram and/or duloxetine, then they will be treated openly with an approved antidepressant.” NCT01973283

“Patients were assessed before and 5 hours after single-dose, overencapsulated 10-mg doses of escitalopram (SSRI) or placebo, with 1 week between conditions.” PMID 26376447 Sep 2015

“Throughout the study, all subjects will receive either escitalopram (Lexapro) or citalopram (Celexa) on the basis of the study doctor's clinical judgment.” NCT00361218

“Preliminary data indicate that a single dose of the SSRI Escitalopram is sufficient to induce LTP-like effects in the motor cortex of healthy volunteers” NCT02865642

“All of the participants will take 10 mg of oral escitalopram daily for 4 weeks, with flexible adjustment thereafter based on clinical response.” PMID 40876882 Aug 2025

“The investigators will use the SSRI escitalopram (Lexapro), which has received FDA approval for the treatment of anxiety, in 5 mg capsules.” NCT02516332

“Subjects eligible to participate in the study will receive IM saline and will use escitalopram 15 mg and aripiprazole 5 mg as randomized” NCT04234776

“primary focus will be on serotonin-reuptake inhibiting antidepressant (escitalopram 5-20mg, sertraline 50-200 mg daily) monotherapy” NCT02752542

“Medication will begin with 10mg escitalopram daily (or its equivalent), increased to 30 mg/day (or its equivalent) by week 6” NCT00787501

“Patients with MDD, in use of antidepressants (fluoxetine, citalopram, escitalopram, bupropion, etc.) without psychotherapy.” NCT02624102

“This arm will receive treatment with the chemical neuromodulator escitalopram (Lexapro) at 10 mg once per day for 8 weeks.” NCT05519683

“medication treatment will be a selective serotonin reuptake inhibitor (either fluoxetine, sertraline or escitalopram).” NCT04598230

“selective serotonin reuptake inhibitors (fluoxetine, sertraline, citalopram, escitalopram, paroxetine or fluvoxamine)” NCT03993535

Escitalopram oxalate (antidepressant) 20 mg/day oral + 20, 30, or 50 mg SPD489 oral once daily for 6 weeks” NCT00905424

“Duloxetine, escitalopram, fluoxetine, paroxetine IR, sertraline, venlafaxine XR; dosing according to label” NCT01838681

Escitalopram, a highly selective serotonin reuptake inhibitor, is usually effective for panic dis order” NCT00767871

“sertraline: 100-200mg, citalopram 20-40mg, escitalopram 10-20mg, paroxetine 20-60mg; fluoxetine 20-80mg” NCT01903447

Escitalopram oxalate tablets should be taken orally once every morning for 2 months, each time 10-20mg” NCT04037111

“Subjects receive 10 mg escitalopram daily for four weeks and 10 or 20 mg for an additional six weeks.” NCT00826111

“After completion of imaging procedures, patients will receive treatment with escitalopram 10-20mg.” NCT02711215

“AD: aripiprazole, bupropion, duloxetine, escitalopram, mirtazapine, sertraline, venlafaxine” NCT04747314

“Participants receive 4 weeks SSRI treatment with escitalopram (10mg/day) as standard drug.” NCT06545474

“which included escitalopram, sertraline, and desvenlafaxine in a prescribed sequence.” PMID 27788313 Oct 2016

“Participants will take escitalopram (10 - 20 mg/day)+ placebo (1 to 3 pills per day).” NCT00590863

“fluoxetine, paroxetine, sertraline, fluvoxamine, escitalopram, clomipramine” NCT02431845

“Patients who cannot tolerate fluoxetine will be switched to escitalopram.” NCT06153004

Escitalopram, 20mg-40mg daily or Sertraline 50-150 mg daily for 12 weeks” NCT02137369

Escitalopram (SCIT) is frequently prescribed to breastfeeding women.” PMID 32162723 Apr 2020

Escitalopram will similarly be dosed between 5 mg and 30 mg daily.” NCT04973930

“Participants will receive outpatient treatment with escitalopram.” NCT07488910

“Fluoxetine, escitalopram, citalopram, fluvoxamine, or sertraline” NCT03222570

“the other receiving an SSRI (e.g., sertraline or escitalopram)” NCT06957223

“paroxetine, fluoxetine, sertraline, escitalopram, citalopram” NCT00944996

Escitalopram 20 mg tablet plus one placebo tablet” NCT04344678

“antidepressant monotherapy(escitalopram) group” NCT06054321

escitalopram 10mg once daily for 3 months” NCT00902421

escitalopram, citalopram or sertraline” NCT02279953

“- Escitalopram 10-20 mg/d. N06AB10” NCT01305707

escitalopram (Lexapro and others)” NCT01944657

escitalopram (Lexapro®) tablets” NCT03538691

Escitalopram (Lexapro)5-30;” NCT00074815

escitalopram 10-20mg/day” NCT02023567

escitalopram (Lexapro)” NCT01460212

Escitalopram (Lexapro)” NCT00797966

Escitalopram, Lexapro” NCT01916824

escitalopramNCT00157547

escitalopramNCT01488266

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NCT05017311

NCT00215228

NCT01090700

NCT07077291

NCT06965569

NCT00220480

NCT01398514

NCT00114374

NCT03323697

NCT00723060

NCT00148447

NCT06826326

NCT05840692

NCT03388164

NCT01111539

NCT06937476

NCT04977232

NCT00488670

NCT01214044

NCT03887624

NCT05536414

NCT00146900

NCT01123707

NCT00933894

NCT05389046

NCT01404871

NCT01364649

NCT01101685

NCT00692263

NCT02623231

NCT02623205

NCT00456937

NCT04543123

NCT04623099

NCT04476030

NCT00810069

NCT00272025

NCT03527043

NCT02191397

NCT00456430

NCT01538693

NCT00531622

NCT02285699

NCT01368432

NCT01119638

NCT07074652

NCT00456014

NCT00822744

NCT00464191

NCT00636649

NCT00219349

NCT03321006

NCT01997580

NCT04221256

NCT00598052

NCT00423969

NCT00902226

NCT05603104

NCT02532660

NCT00708240

NCT00595699

NCT06325605

NCT01655706

NCT01894815

NCT02422186

NCT03912974

NCT05973786

NCT04069819

NCT02407821

NCT07645807

NCT00519428

NCT01787240

NCT05950061

NCT02389465

NCT03187093

NCT00955474

NCT00917059

NCT00708396

NCT00295347

NCT00887679

NCT04697693

NCT01764867

NCT00464711

NCT00971815

NCT00754793

NCT00958633

NCT01020799

NCT01931202

NCT03812588

NCT03487211

NCT00329446

NCT04162522

NCT00351910

NCT00101452

NCT00594269

NCT00833469

NCT00220701

NCT00162968

NCT01360866

NCT00360399

NCT00108979

NCT00136318

NCT02161458

NCT00105586

NCT06025474

NCT00243477

NCT02082392

NCT00109044

NCT02493868

NCT05004987

NCT00071643

NCT04336228

NCT00305500

NCT00536172

NCT01401595

NCT03779789

NCT07025590

NCT05818735

NCT00248651

NCT00837564

NCT00116532

NCT00231335

NCT00517764

NCT00222820

NCT03108846

NCT05480150

NCT02497287

NCT00133276

NCT03852160

NCT07432815

NCT00229333

NCT01541475

NCT01045083

NCT01477203

NCT02620150

NCT00260624

NCT03623711

NCT01902004

NCT01251471

NCT00601965

NCT00550485

NCT03274817

NCT03993457

NCT01896349

NCT03010761

NCT02480400

NCT02423694

NCT00200902

NCT00475878

NCT03909217

NCT06705478

NCT00953745

NCT00584571

NCT00452543

NCT00351169

NCT07331987

NCT01363310

NCT01587326

NCT00824044

NCT01309776

NCT00404755

NCT00397059

NCT00140257

NCT03899194

NCT03652870

NCT00166114

NCT00610506

NCT00296933

NCT00234312

NCT00209170

NCT06758167

NCT00628914

NCT01418274

NCT01741142

NCT01271244

NCT05480878

NCT00115011

NCT02122939

NCT00807248

NCT00985504

NCT00420004

NCT01797380

NCT02237937

NCT00918684

NCT02072278

NCT07628153

NCT00989053

NCT01324700

NCT00177671

NCT05588102

NCT04388202

NCT04013464

NCT00419471

NCT00902564

NCT07590609

NCT01369095

NCT02869035

NCT00785434

NCT04763135

NCT02818751

NCT01082237

NCT00080158

NCT00375843

NCT02469545

NCT00866593

NCT00935246

NCT00648661

NCT02332291

NCT00736021

NCT00746239

NCT01522092

NCT00648570

NCT00361790

NCT00825825

NCT00177294

NCT00177216

NCT00232700

NCT00754936

NCT00156325

NCT06680531

NCT01594866

NCT01479829

NCT01728194

NCT01628783

NCT00967408

NCT02418585

NCT03522844

NCT01870843

NCT00656552

NCT01638689

NCT03148522

NCT03464383

NCT01551225

NCT01103180

NCT00417118

NCT00702780

NCT06696482

NCT03522987

NCT06675851

NCT01871701

NCT01198795

NCT00566202

Known as Cipralex “The aim of this study is to evaluate the therapeutic effect of escitalopram (cipralex) in the treatment of negative symptoms in schizophrenic patients receiving either typical...” NCT00148447
7

“The purpose of the study is to evaluate tolerability and efficacy of escitalopram (Cipralex) treatment in doses beyond 20mg (20-40 mg/d) in patients with OCD and schizophrenia,...” NCT00708396

Cipralex (escitalopram)” NCT00368862

Cipralex (escitalopram)” NCT06675851

NCT01293838

NCT01961180

NCT00485888

NCT01644071

Known as ESC “BACKGROUND: In this study, the impact of quetiapine fumarate extended release (QXR) and escitalopram (ESC) on HPA axis activity was investigated in depressed patients in...” PMID 24275013 Oct 2013
5

“In our experience, venlafaxine (VLX) and escitalopram (ESC) are the two antidepressants best tolerated and least likely to interfere with oncotherapy for patients with MDD and...” NCT04973930

escitalopram (ESC) added a second phase using a synchronous, videoconference (VC) format” PMID 40324655 May 2025

“initially treated with a combination of escitalopram (ESC) plus bupropion (BUP)” PMID 19820552 Sep 2009

“plus escitalopram (ESC) 20 mg once daily for six weeks” PMID 34545997 Sep 2021

“in combination with escitalopram (ESC).” PMID 31630035 Oct 2019

Known as Escitalopram (as oxalate) ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as Escitalopram 20 mg (Lexapro, Tablet) Escitalopram 20 mg (Lexapro, Tablet)NCT01871701
Known as Escitalopram = Cipralex/Lexapro/Seroplex/Sipralexa Escitalopram = Cipralex/Lexapro/Seroplex/SipralexaNCT00807248
Known as escitalopram = Lexapro escitalopram = LexaproNCT00296712
3

“Escitalopram (Lexapro)” NCT00610506

“escitalopram (Lexapro)” NCT01460212

“Escitalopram, Lexapro” NCT01916824

Known as Escitalopram Oxalate “The proposed study will consist of a double-blinded, randomized controlled trial using a crossover design to assess the effects of SSRIs (escitalopram oxalate, Lexapro®, Forest...” NCT01788969
10

“For women, a pregnancy test will also be administered no more than 48 hours before SPECT-CT imaging and the beginning of escitalopram oxalate (Lexapro) treatment.” NCT01401595

Escitalopram oxalate (antidepressant) 20 mg/day oral + 20, 30, or 50 mg SPD489 oral once daily for 6 weeks” NCT00905424

Escitalopram oxalate (Reconter), 10mg/day (first 3 weeks) and 20mg/day (week 3 to week 10).” NCT01894815

escitalopram oxalate , a selective-5HT reuptake inhibitor (SSRI)” NCT01538693

“in Depressed Patients on Escitalopram Oxalate (Lexapro)” NCT00416221

“Escitalopram (as escitalopram oxalate) tablet” NCT07645807

Escitalopram Oxalate Tablets 20 mg” NCT00648661

Escitalopram oxalate tablets” NCT06680531

“Drug: Escitalopram OxalateNCT05004987

NCT05737511

Known as escitalopram/Cipralex escitalopram/CipralexNCT01219686
Known as ESERTIA ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as ESITOL ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as Innovator Escitalopram “fixed dose(generic escitalopram 10mg/d or Innovator Escitalopram(Lexapro®) 10mg/d)” NCT00866593
Known as Lexapro “The proposed study will consist of a double-blinded, randomized controlled trial using a crossover design to assess the effects of SSRIs (escitalopram oxalate, Lexapro®, Forest...” NCT01788969
29

“Participants receive only clinical routine antidepressant treatment,Which include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa)...” NCT01831440

“Antidepressant medications may include the following: citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil CR), sertraline (Zoloft), venlafaxine XR (Effexor XR),...” NCT00564278

“The goal of this clinical trial is to evaluate the acute effects of escitalopram (Lexapro®) on select brain networks during task-based functional magnetic resonance imaging...” NCT06826326

“The purpose of the study is to evaluate the efficacy and safety of flexible doses of escitalopram (Lexapro) compared to sertraline (Zoloft) for treatment of Dysthymic Disorder.” NCT00234312

“Throughout the study, all subjects will receive either escitalopram (Lexapro) or citalopram (Celexa) on the basis of the study doctor's clinical judgment.” NCT00361218

“This study compares the effectiveness of the combination of antidepressants: Lexapro and Pramipexole, with the effectiveness of each antidepressant alone.” NCT00086307

“The investigators will use the SSRI escitalopram (Lexapro), which has received FDA approval for the treatment of anxiety, in 5 mg capsules.” NCT02516332

“Escitalopram (Lexapro) 5mg daily for first 2 weeks, and then 10 mg daily for 8 weeks versus Placebo for 10 weeks” NCT02153567

“the SSRI escitalopram (Lexapro), with the most recently available SNRI, duloxetine” NCT00215228

“Venlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro)” NCT00200902

“This medication is called Lexapro (Escitalopram).” NCT01398514

“escitalopram (Lexapro and others)” NCT01944657

“escitalopram (Lexapro®) tablets” NCT03538691

“Escitalopram (Lexapro)5-30;” NCT00074815

“Escitalopram (Lexapro)” NCT00797966

“Escitalopram : LexaproNCT00935246

“Escitalopram (Lexapro)” NCT00156325

“Escitalopram (Lexapro)” NCT00260624

“Escitalopram (Lexapro)” NCT00277108

“escitalopram (Lexapro)” NCT00423969

“Escitalopram (Lexapro)” NCT06692361

NCT00749125

NCT01078870

NCT00643162

NCT02579343

NCT00416221

NCT01244724

NCT01753882

NCT05519683

Known as Lexapro (escitalopram) Lexapro (escitalopram)NCT00642694
1

Lexapro (escitalopram)NCT00754793

Known as LU 26-054-0 ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as LU-26-054 ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as LU-26-054-O ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as NSC-758934 ChEMBL registry synonym — accepted as the source's own label CHEMBL1508
Known as Reconter “Escitalopram oxalate (Reconter), 10mg/day (first 3 weeks) and 20mg/day (week 3 to week 10).” NCT01894815
Known as S-citalopram “effect of an antidepressive pre-treatment over two weeks and a continuously concomitant treatment with Escitalopram (S-citalopram) on frequency and severity of depression” NCT00136318
1

NCT00655057

Known as SCIT “To define these subtypes, a prospectively-treated cohort of 100 patients will be randomized to receive either escitalopram (s-CIT) or CBT for the first 12 weeks, with...” NCT00367341
2

“Subjects will be randomized to receive either escitalopram (s-CIT) or CBT for 12 weeks.” NCT02137369

“Escitalopram (SCIT) is frequently prescribed to breastfeeding women.” PMID 32162723 Apr 2020

Known as Seroplex “Admnistration of 18FAV45 if patient is compliant with one of those treatment: Seroplex, Zoloft, Deroxat, Venlafaxine, Mirtazapine, Moclamine,” NCT01962753
1

NCT02042573

Action Inhibit “a selective serotonin reuptake inhibitor” NCT00070941
1

“Serotonin transporter inhibitor” CHEMBL1508

Modality Small molecule “Escitalopram (an SSRI-compound)” NCT00971815
Route Oral “40 subjects receiving oral escitalopram 20mg or 40 mg daily, in two divided doses, and placebo SAM-e.” NCT00070941