Early Versus Delayed Switch in Medication in Patients With Major Depressive Disorder

Summary

This study investigates two different approaches to the change in antidepressant treatment when an initial treatment is not effective: early intervention or delayed intervention. Two hypothesis will be tested: 1. that time to confirmed response is shorter in the early intervention strategy vs. delayed intervention strategy 2. that the time to confirmed remission is shorter in the early intervention strategy compared to delayed intervention strategy.

Timeline

Start

2008-11

Primary completion

2010-02

Completion

2010-03

Outcome

Missed primary endpoint

registry Early Intervention vs Delayed Intervention; p = 0.213; Kaplan-Meier Analysis NCT00810069 ↗

registry Early Intervention vs Delayed Intervention; p = 0.075; Kaplan-Meier analysis NCT00810069 ↗

paper Although no differences in the primary end points were found, a higher remission rate was seen with the early switch strategy. PMID 22722513 ↗

Publications

• Romera I, Perez V, Menchon JM, Schacht A, Papen R, Neuhauser D, Abbar M, Svanborg P, Gilaberte I. Early switch strategy in patients with major depressive disorder: a double-blind, randomized study. J Clin Psychopharmacol. 2012 Aug;32(4):479-86. doi: 10.1097/JCP.0b013e31825d9958.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Duloxetine	Small molecule	60 mg	—
Subject	Duloxetine	Small molecule	120 mg	—
Subject	Escitalopram	Small molecule	10 mg	—
Subject	Escitalopram	Small molecule	20 mg	—

Indications