Efficacy and Tolerability of Escitalopram and Duloxetine in Outpatients With Major Depressive Disorder

Phase 4 Completed 294 enrolled H. Lundbeck A/S

RandomizedParallel-groupDouble-blindTreatment

Summary

The primary objective of this study was to compare the efficacy of escitalopram with that of duloxetine in outpatients with Major Depressive Disorder (MDD) after 24 weeks of treatment. The study hypothesis was that there were clinically important differences between the two drugs in terms of efficacy and adverse event profiles.

Timeline

Start: 2005-09
Primary completion: 2006-09
Completion: 2006-11

Outcome

Missed primary endpoint

paper a difference of 1.7 points (p = 0.055, one-sided). PMID 17559755 ↗

Publications

Results Wade A, Gembert K, Florea I. A comparative study of the efficacy of acute and continuation treatment with escitalopram versus duloxetine in patients with major depressive disorder. Curr Med Res Opin. 2007 Jul;23(7):1605-14. doi: 10.1185/030079907x210732.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Duloxetine	Small molecule	60 mg	Oral
Subject	Escitalopram	Small molecule	20 mg	Oral