Antidepressant Treatment Plus Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Older Adults

NCT00601965 ↗

Completed 73 enrolled Veterans Medical Research Foundation National Institute of Mental Health (NIMH) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study will assess whether adding cognitive behavioral therapy to the antidepressant escitalopram is effective in reducing anxiety in older adults with generalized anxiety disorder.

Timeline

Start: 2007-10
Primary completion: 2011-09
Completion: 2011-09

Outcome

Met primary endpoint

paper Both escitalopram and CBT prevented relapse compared with placebo. PMID 23680817 ↗

registry MEAN Escitalopram + CBT: 52.8 (Standard Deviation 2.6) units on a scale NCT00601965 ↗

registry Escitalopram + CBT vs Escitalopram + no CBT vs Placebo + CBT vs Placebo + no CBT; p = 0.01; Mixed Models Analysis NCT00601965 ↗

Publications

Wetherell JL, Petkus AJ, White KS, Nguyen H, Kornblith S, Andreescu C, Zisook S, Lenze EJ. Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults. Am J Psychiatry. 2013 Jul;170(7):782-9. doi: 10.1176/appi.ajp.2013.12081104.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Escitalopram	Small molecule	20 mg	Oral