drugset / Trial / NCT04245748
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
RandomizedParallel-groupDouble-blindTreatment
Summary
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Timeline
- Start
- 2020-03-01
- Primary completion
- 2025-07-30
- Completion
- 2025-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Duloxetine | Small molecule | — | — |
| Comparator | Escitalopram | Small molecule | — | — |