Impact of Escitalopram on Sperm DNA Fragmentation

Summary

Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation. Hormone profiles, semen analysis, sperm DNA fragmentation, and sexual function will be measured at baseline, after 6 weeks of therapy, and 4 weeks after discontinuation of therapy (10 weeks into study).

Timeline

Start

2017-10-01

Primary completion

2023-04-04

Completion

2024-05-31

Drugs

Indications