A PET Study to Determine Alterations in Serotonin Levels in Human Brain After a Single Dose of Escitalopram

Phase 1 Completed 10 enrolled Karolinska Institutet

NaSingle-groupOpen-labelBasic science

Summary

Healthy males were examined with positron emission tomography (PET) and the radioligand 11C-AZ10419369, before and after administration of a single dose escitalopram. A change in the binding potential of 11C-AZ10419369 between the baseline and the post-dose condition was hypothesized to reflect a change in serotonin concentration.

Timeline

Start: 2010-09
Primary completion: 2011-02
Completion: 2012-07

Publications

Nord M, Finnema SJ, Halldin C, Farde L. Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain. Int J Neuropsychopharmacol. 2013 Aug;16(7):1577-86. doi: 10.1017/S1461145712001617. Epub 2013 Jan 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Escitalopram	Small molecule	20 mg	Oral

Indications

No indication recorded.