MBCT and Escitalopram for Treatment-Resistant Depression in Older Adults

Summary

This study is a randomized controlled trial designed to investigate the synergistic effects of combining mindfulness-based cognitive therapy (MBCT) with escitalopram hydrobromide versus escitalopram alone on cognitive function, depressive symptoms, and quality of life in older adults diagnosed with treatment-resistant depression (TRD) and cognitive impairment.

Timeline

Start

2020-02-01

Primary completion

2022-05-30

Completion

2022-05-30

Publications

• Wei Z, Zhang S, Ma J, Zhang Y, Li Y, Wen A. Combining Mindfulness-Based Cognitive Therapy With Escitalopram for Cognitive and Emotional Recovery in Older Adults With Treatment-Resistant Depression. J Clin Psychol. 2026 Apr 23. doi: 10.1002/jclp.70137. Online ahead of print.

Drugs

Indications