Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder

Summary

The main objective was to compare the differences of PSG parameters and plasma melatonin levels before and after treatment with escitalopram for 8 weeks. Polysomnography (PSG) was detected over a night and blood samples were collected at 4 h intervals for 24 h from 13 male healthy controls and 13 male MDD patients before and after treatment with escitalopram for 8 weeks. The outcome measures included the levels of plasma melatonin, PSG parameters (include sleep architecture and power analysis) and scales.

Timeline

Start

2016-05-01

Primary completion

2018-05-31

Completion

2018-12-30

Drugs

Indications