drugset / Trial / NCT04221256
Dose-finding Study of Selective Serotonin Reuptake Inhibitors to Enhance Neuroplasticity
RandomizedCrossoverTriple-blindTreatment
Summary
The brain is able to change throughout life in response to learning, or injury, or to adapt to changes in the environment, which is known as neuroplasticity. Stroke survivors suffer disabling chronic motor impairments that have proven challenging to improve. Increasing neuroplasticity using selective serotonin reuptake inhibitors (SSRIs) is a promising approach to promote motor recovery in patients with stroke.
Timeline
- Start
- 2020-03-11
- Primary completion
- 2021-02-09
- Completion
- 2021-02-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Escitalopram | Small molecule | 5 mg | — |
| Subject | Escitalopram | Small molecule | 10 mg | — |
| Subject | Escitalopram | Small molecule | 20 mg | — |