drugset / Trial / NCT04221256

Dose-finding Study of Selective Serotonin Reuptake Inhibitors to Enhance Neuroplasticity

NCT04221256

Phase 1/2 Withdrawn Burke Medical Research Institute
RandomizedCrossoverTriple-blindTreatment

Summary

The brain is able to change throughout life in response to learning, or injury, or to adapt to changes in the environment, which is known as neuroplasticity. Stroke survivors suffer disabling chronic motor impairments that have proven challenging to improve. Increasing neuroplasticity using selective serotonin reuptake inhibitors (SSRIs) is a promising approach to promote motor recovery in patients with stroke.

Timeline

Start
2020-03-11
Primary completion
2021-02-09
Completion
2021-02-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Escitalopram Small molecule 5 mg
Subject Escitalopram Small molecule 10 mg
Subject Escitalopram Small molecule 20 mg

Indications