Short-term Study of Combination Treatment of Escitalopram and Gaboxadol in Major Depressive Disorder

Phase 2 Completed 490 enrolled H. Lundbeck A/S

RandomizedParallel-groupDouble-blindTreatment

Summary

To compare the efficacy of escitalopram fixed dose 20 mg/day in combination with fixed doses of gaboxadol (5 and 10 mg/day) versus escitalopram fixed dose 20 mg/day after 8 weeks of treatment in patients with Major Depressive Disorder

Timeline

Start: 2008-11
Primary completion: 2009-12
Completion: 2010-02

Publications

Results Kasper S, Ebert B, Larsen K, Tonnoir B. Combining escitalopram with gaboxadol provides no additional benefit in the treatment of patients with severe major depressive disorder. Int J Neuropsychopharmacol. 2012 Jul;15(6):715-25. doi: 10.1017/S146114571100112X. Epub 2011 Oct 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Escitalopram	Small molecule	20 mg	—
Subject	gaboxadol	Small molecule	5 mg	—
Subject	gaboxadol	Small molecule	10 mg	—

Short-term Study of Combination Treatment of Escitalopram and Gaboxadol in Major Depressive Disorder

Summary

Timeline

Publications

Drugs

Indications