Short-term Study of Combination Treatment of Escitalopram and Gaboxadol in Major Depressive Disorder

Summary

To compare the efficacy of escitalopram fixed dose 20 mg/day in combination with fixed doses of gaboxadol (5 and 10 mg/day) versus escitalopram fixed dose 20 mg/day after 8 weeks of treatment in patients with Major Depressive Disorder

Timeline

Start

2008-11

Primary completion

2009-12

Completion

2010-02

Outcome

Missed primary endpoint

registry Escitalopram 20 mg and Placebo (Orally, Once Daily) vs Escitalopram 20 mg and Gaboxadol 10 mg (Orally, Once Daily); p = 0.6405 NCT00807248 ↗

registry Escitalopram 20 mg and Placebo (Orally, Once Daily) vs Escitalopram 20 mg and Gaboxadol 5 mg (Orally, Once Daily); p = 0.6227 NCT00807248 ↗

paper There was no statistically significant difference in the mean change from baseline in MADRS total score between the 20 mg escitalopram+10 mg gaboxadol group PMID 22008735 ↗

Publications

• Results Kasper S, Ebert B, Larsen K, Tonnoir B. Combining escitalopram with gaboxadol provides no additional benefit in the treatment of patients with severe major depressive disorder. Int J Neuropsychopharmacol. 2012 Jul;15(6):715-25. doi: 10.1017/S146114571100112X. Epub 2011 Oct 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Escitalopram	Small molecule	20 mg	—
Subject	Gaboxadol	Unknown	5 mg	—
Subject	Gaboxadol	Unknown	10 mg	—

Indications