drugset / Trial / NCT00375843
Brain Activity Changes and Treatment Response in Depressed People Who Are Receiving Antidepressant Medication
Non-randomizedSingle-groupOpen-labelTreatment
Summary
This study will examine how brain activity is affected by antidepressant treatment and how changes in brain activity relate to treatment response in people with depression.
Timeline
- Start
- 2005-01
- Primary completion
- 2007-06
- Completion
- 2008-03
Publications
- Background Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M. Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry. 2002 Jan;159(1):122-9. doi: 10.1176/appi.ajp.159.1.122.
- Background Cook IA, Leuchter AF, Morgan M, Witte E, Stubbeman WF, Abrams M, Rosenberg S, Uijtdehaage SH. Early changes in prefrontal activity characterize clinical responders to antidepressants. Neuropsychopharmacology. 2002 Jul;27(1):120-31. doi: 10.1016/S0893-133X(02)00294-4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Escitalopram | Small molecule | 30 mg | — |
| Comparator | Sertraline | Small molecule | 200 mg | — |