drugset / Trial / NCT00074815
Treatment of Obsessive Compulsive Disorder in Children
RandomizedParallel-groupSingle-blindTreatment
Summary
This study will determine whether cognitive behavioral therapy delivered by either psychologists or psychiatrists can improve the effectiveness of serotonin reuptake inhibitor treatment in children with obsessive compulsive disorder.
Timeline
- Start
- 2003-09
- Primary completion
- 2009-11
- Completion
- 2009-11
Publications
- Results Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, Foa EB, March JS. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial. JAMA. 2011 Sep 21;306(11):1224-32. doi: 10.1001/jama.2011.1344.
- Conelea CA, Selles RR, Benito KG, Walther MM, Machan JT, Garcia AM, Sapyta J, Morris S, Franklin M, Freeman JB. Secondary outcomes from the pediatric obsessive compulsive disorder treatment study II. J Psychiatr Res. 2017 Sep;92:94-100. doi: 10.1016/j.jpsychires.2017.04.001. Epub 2017 Apr 7.
- Conelea CA, Walther MR, Freeman JB, Garcia AM, Sapyta J, Khanna M, Franklin M. Tic-related obsessive-compulsive disorder (OCD): phenomenology and treatment outcome in the Pediatric OCD Treatment Study II. J Am Acad Child Adolesc Psychiatry. 2014 Dec;53(12):1308-16. doi: 10.1016/j.jaac.2014.09.014. Epub 2014 Oct 2.
- Freeman JB, Choate-Summers ML, Garcia AM, Moore PS, Sapyta JJ, Khanna MS, March JS, Foa EB, Franklin ME. The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods. Child Adolesc Psychiatry Ment Health. 2009 Jan 30;3(1):4. doi: 10.1186/1753-2000-3-4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Citalopram | Small molecule | 10 mg | — |
| Background | Citalopram | Small molecule | 60 mg | — |
| Background | Clomipramine | Small molecule | 25 mg | — |
| Background | Clomipramine | Small molecule | 200 mg | — |
| Background | Escitalopram | Small molecule | 5 mg | — |
| Background | Escitalopram | Small molecule | 30 mg | — |
| Background | Fluoxetine | Small molecule | 10 mg | — |
| Background | Fluoxetine | Small molecule | 60 mg | — |
| Background | Fluvoxamine | Unknown | 25 mg | — |
| Background | Fluvoxamine | Unknown | 300 mg | — |
| Background | Paroxetine | Small molecule | 10 mg | — |
| Background | Paroxetine | Small molecule | 50 mg | — |
| Background | Sertraline | Small molecule | 25 mg | — |
| Background | Sertraline | Small molecule | 200 mg | — |
| Background | Venlafaxine | Small molecule | 25 mg | — |
| Background | Venlafaxine | Small molecule | 37.5 mg | — |
| Background | Venlafaxine | Small molecule | 225 mg | — |