Drugs / Citalopram
last change Jun 2026 re-read 8 days ago

Citalopram

Small molecule

Developed for
depressive disorder · major depressive disorder · acute coronary syndrome · Alzheimer disease · anxiety · dementia · schizophrenia · stroke disorder
+35 more · autism spectrum disorder · cocaine dependence · gastroesophageal reflux disease · obsessive-compulsive disorder · Parkinson disease · traumatic brain injury · alcohol abuse · alcohol dependence · asthma · autism · bipolar disorder · circadian rhythm sleep disorder, delayed sleep phase type · cocaine abuse · dysthymic disorder · fibromyalgia · Friedreich ataxia · frontotemporal dementia · Huntington disease · irritable bowel syndrome · myalgic encephalomeyelitis/chronic fatigue syndrome · panic disorder · prurigo nodularis · rheumatoid arthritis · schizophreniform disorder · vascular dementia · bipolar depression · borderline personality disorder · burning mouth syndrome · ischemic stroke · mood disorder · myocardial infarction · myofascial pain syndrome · neurotic depression · premature ejaculation · temporomandibular joint disorder
Investigated by
National Institute of Mental Health (NIMH) · University of Oxford · National Heart, Lung, and Blood Institute (NHLBI) · New York State Psychiatric Institute · University of Pittsburgh · Actavis Inc.
+138 more · National Institute on Drug Abuse (NIDA) · Sunnybrook Health Sciences Centre · University of Michigan · Centre for Addiction and Mental Health · Columbia University · Emory University · Indiana University · Massachusetts General Hospital · Mayo Clinic · National Institute of Mental Health and Neuro Sciences, India · National Institute on Aging (NIA) · Ontario Mental Health Foundation · Stanford University · The University of Texas Health Science Center, Houston · Torrent Pharmaceuticals Limited · Universitaire Ziekenhuizen KU Leuven · University of Bath · University of North Carolina, Chapel Hill · 59th Medical Wing · Alliance for Clinical Trials in Oncology · Alzheimer Society of Canada · Amsterdam UMC, location VUmc · Artesis University College, Antwerp · Asthma UK · Big Health Inc. · Boehringer Ingelheim · Boston University · Bruce Pollock · CIHR Canadian HIV Trials Network · California Pacific Medical Center Research Institute · Canadian Institutes of Health Research (CIHR) · Capital Medical University · Catalan Institute of Oncology · Central Hospital, Nancy, France · Centre Hospitalier Universitaire Vaudois · Centre de Recherche du Centre Hospitalier de l'Université de Montréal · Chang Gung Memorial Hospital · Charite University, Berlin, Germany · Chih-Wei Tang · Ciusss de L'Est de l'Île de Montréal · Cure Huntington's Disease Initiative (CHDI) · Dalian Seventh People's Hospital · Danish University Antidepressant Group · Demensforbundet, Norway · Ege University · First Hospital of China Medical University · French National Institute of Health and Medical Research · German Research Foundation · Gitte Moos Knudsen · Hadassah Medical Organization · Hamilton Health Sciences Corporation · Hannover Medical School · Henry Ford Health System · HolsboerMaschmeyer NeuroChemie GmbH · Hospices Civils de Lyon · Hospital Regional 1o de Octubre · Hospital Universitari de Bellvitge · Hunter Holmes McGuire VA Medical Center · Idorsia Pharmaceuticals Ltd. · Innlandet Hospital Trust · Irish Cancer Society · JHSPH Center for Clinical Trials · James A. Haley Veterans Administration Hospital · Jing-Ho Mental Hospital, Taiwan · John V. Campo, M.D. · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · King's College London · Liam Heaney · Marina Klein · Max-Planck-Institute of Psychiatry · McMaster University · Mclean Hospital · Medical University of Vienna · Medtronic - MITG · all 144 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) CELEXA — 1998-07-17 fda.gov ↗

Trials 100 · started per year

today
US approved 1998
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1995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT06796946 Jun → Dec 2026 expected — University of Huelva Not yet recruiting No outcome recorded
Phase 0 NCT02269540 Oct 2014 → Jun 2018 major depressive disorder Centre for Addiction and Mental Health Completed No outcome recorded
Phase 114 trials
Phase 1 NCT04097288 Sep 2019 → Feb 2020 female stress incontinence University Hospital Bispebjerg and Frederiksberg Completed No outcome recorded
Phase 1 NCT03907215 Apr → Jun 2019 — Idorsia Pharmaceuticals Ltd. Completed No outcome recorded
Phase 1 NCT03854578 Mar → Aug 2019 major depressive disorder Boehringer Ingelheim Completed Mixed
Phase 1 NCT02092974 Apr → Dec 2014 — Charite University, Berlin, Germany Completed No outcome recorded
Phase 1 NCT01978782 Jan → Apr 2014 HIV infectious disease, depressive disorder Radboud University Medical Center Completed No outcome recorded
Phase 1 NCT01951053 Jan → May 2010 — Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Completed No outcome recorded
Phase 1 NCT00538889 Aug → Nov 2007 — Wyeth is now a wholly owned subsidiary of Pfizer Completed No outcome recorded
Phase 1 NCT00609531 Jan 2007 → Aug 2009 autism spectrum disorder University of North Carolina, Chapel Hill Completed No outcome recorded
Phase 1 NCT00613470 Mar 2005 → May 2013 depressive disorder Mayo Clinic Completed No outcome recorded
Phase 1 NCT00865943 Jul → Aug 2003 — Actavis Inc. Completed No outcome recorded
Phase 1/23 trials · 1 met primary
Phase 1/2 NCT06017037 May 2023 → May 2024 atypical depressive disorder University of Oxford Unknown No outcome recorded
Phase 1/2 NCT01667744 Jan → Feb 2016 acute coronary syndrome Henry Ford Health System Withdrawn No outcome recorded Stop: Business
Phase 1/2 NCT01032018 Jan 2010 → Jan 2012 acute coronary syndrome, depressive disorder Columbia University Completed Met primary
Phase 217 trials · 1 met primary · 5 missed
Phase 2 NCT05063604 May 2022 breast cancer, major depressive disorder Hospital Universitari de Bellvitge Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT04766229 Jun 2021 → Nov 2022 cancer, insomnia University College Dublin Completed No outcome recorded
Phase 2 NCT04497168 Apr 2021 → Mar 2026 Parkinson disease University of Michigan Completed No outcome recorded
Phase 2 NCT03222570 Feb 2018 → Apr 2024 depressive disorder University of Minnesota Completed Missed primary
Phase 2 NCT03899285 Jan → Dec 2018 major depressive disorder Ciusss de L'Est de l'Île de Montréal Completed No outcome recorded
Phase 2 NCT02458690 Jul 2015 → Aug 2019 coronary artery disorder, dysthymic disorder, major depressive disorder, stroke disorder Indiana University Completed Missed primary
Phase 2 NCT02113943 Apr → Jun 2014 — French National Institute of Health and Medical Research Completed No outcome recorded
Phase 2 NCT02000726 Jul 2013 → Jun 2014 depressive disorder University of Michigan Withdrawn No outcome recorded Stop: Business
Phase 2 NCT02080832 Feb 2010 → Feb 2016 cocaine dependence Virginia Commonwealth University Completed No outcome recorded
Phase 2 NCT00742573 Aug 2008 → Jan 2014 major depressive disorder New York State Psychiatric Institute Completed No outcome recorded
Phase 2/33 trials · 1 met primary
Phase 2/3 NCT00962039 Jul 2004 → Apr 2010 anxiety John V. Campo, M.D. Completed Mixed
Phase 2/3 NCT00080158 Mar 2004 → Jun 2007 depressive disorder New York State Psychiatric Institute Completed No outcome recorded
Phase 2/3 NCT00018902 Jan 2001 → Mar 2007 depressive disorder University of Pittsburgh Completed Met primary
Phase 39 trials · 2 met primary · 1 missed
Phase 3 NCT05041582 Sep 2021 → Aug 2024 stroke disorder Chih-Wei Tang Unknown No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT00898807 Jul 2009 → Sep 2013 Alzheimer disease JHSPH Center for Clinical Trials Completed Met primary
Phase 3 NCT00317746 Nov 2006 → Mar 2012 HIV infectious disease, depressive disorder, hepatitis C virus infection Marina Klein Completed Missed primary
Phase 3 NCT00363909 Nov 2006 → Jun 2007 breast cancer Alliance for Clinical Trials in Oncology Completed Met primary
Phase 3 NCT00361218 Oct 2005 → Dec 2008 major depressive disorder Massachusetts General Hospital Completed No outcome recorded
Phase 3 NCT00249886 Sep 2002 → Nov 2006 major depressive disorder Sunnybrook Health Sciences Centre Withdrawn No outcome recorded
Phase 3 NCT00000368 Feb 1999 → Jul 2004 agoraphobia, panic disorder New York State Psychiatric Institute Completed No outcome recorded
Phase 3 NCT00009204 Sep 1995 → Apr 2000 Alzheimer disease, vascular dementia Bruce Pollock Completed No outcome recorded
Phase 424 trials · 2 met primary · 1 missed
Phase 4 NCT03499171 May 2019 → Apr 2021 gastroesophageal reflux disease Universitaire Ziekenhuizen KU Leuven Unknown No outcome recorded
Phase 4 NCT03993535 Oct 2018 → Apr 2023 obsessive-compulsive disorder University of Sao Paulo Completed No outcome recorded
Phase 4 NCT03746691 Feb → Jul 2017 gastroesophageal reflux disease Universitaire Ziekenhuizen KU Leuven Completed No outcome recorded
Phase 4 NCT02711215 May 2015 → Jan 2020 major depressive disorder Medical University of Vienna Unknown No outcome recorded
Phase 4 NCT02473250 Jan 2015 → Dec 2019 bipolar disorder New York State Psychiatric Institute Completed No outcome recorded
Phase 4 NCT01916824 Aug 2013 → Dec 2015 major depressive disorder Emory University Completed No outcome recorded
Phase 4 NCT01716221 Oct 2012 → Mar 2013 Friedreich ataxia University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT01796132 Aug 2012 → Dec 2016 depressive disorder, lactation disease Centre Hospitalier Universitaire Vaudois Unknown No outcome recorded
Phase 4 NCT01557946 Mar 2012 → Sep 2015 major depressive disorder Mclean Hospital Completed No outcome recorded
Phase 4 NCT01436643 Nov 2011 → Sep 2013 depressive disorder, relapsing-remitting multiple sclerosis Novartis Pharmaceuticals Terminated No outcome recorded Stop: Enrollment
Phase not applicable28 trials · 1 missed
— NCT06949644 Sep 2025 → Jul 2029 expected circadian rhythm sleep disorder, delayed sleep phase type Northwestern University Recruiting No outcome recorded
— NCT06412315 Feb 2025 → Apr 2027 expected depressive disorder University of Oxford Recruiting No outcome recorded
— NCT05627154 May 2021 → Nov 2023 anxiety, depressive disorder University of Oxford Completed No outcome recorded
— NCT05346445 Jan → Nov 2021 — Hospital Regional 1o de Octubre Completed No outcome recorded
— NCT04590612 Jan 2021 → Jan 2022 Parkinson disease, depressive disorder Western University, Canada Unknown No outcome recorded
— NCT04161209 Oct 2019 → Sep 2020 depressive disorder University of Oxford Unknown No outcome recorded
— NCT04169230 Oct 2019 → Sep 2020 depressive disorder University of Oxford Unknown No outcome recorded
— NCT06212284 Feb → Nov 2018 — University of Sussex Completed No outcome recorded
— NCT04776226 Feb 2017 → Mar 2018 depressive disorder, stroke disorder Ege University Completed No outcome recorded
— NCT04145076 Dec 2014 → Feb 2023 autism spectrum disorder King's College London Unknown No outcome recorded
Comparator or background therapy94 trials
Phase 0 NCT03607331 Comparator Sep 2018 → Jul 2019 depressive disorder China Academy of Chinese Medical Sciences Unknown No outcome recorded
Phase 0 NCT03282110 Comparator Nov 2017 → Jun 2018 neurotic depression China Academy of Chinese Medical Sciences Unknown No outcome recorded
Phase 0 NCT04846829 Comparator Apr 2017 → Apr 2028 expected major depressive disorder University of California, Los Angeles Active not recruiting No outcome recorded
Phase 0 NCT01725048 Comparator Jan 2011 → May 2012 major depressive disorder, neoplasm UNC Lineberger Comprehensive Cancer Center Completed No outcome recorded
Phase 1 NCT06192589 Comparator Feb → Sep 2024 drug-induced liver injury Food and Drug Administration (FDA) Completed No outcome recorded

Evidence & citations 15 cited values

Every value below carries the sentence it was read from. 197 sources stand behind the page.

FieldValueCited text
Known as Citalopram “we have restricted the IMPACT list of antidepressants to SSRIs (sertraline, escitalopram, paroxetine, fluoxetine, citalopram), duloxetine, bupropion, and mirtazapine. These...” NCT02458690 ↗
190

“Participants receive only clinical routine antidepressant treatment,Which include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa)...” NCT01831440 ↗

“Antidepressant medications may include the following: citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil CR), sertraline (Zoloft), venlafaxine XR (Effexor XR),...” NCT00564278 ↗

“Medication group is a control group that can choose to use the serotonin reuptake inhibitors (SSRIs) approved by China food and Drug Administration (SFDA) for the treatment of...” NCT03558256 ↗

“ADT such as citalopram, escitalopram, fluoxetine, sertraline, paroxetine, vilazodone, venlafaxine, desvenlafaxine, duloxetine or bupropion prescribed in accordance with its...” NCT01838876 ↗

“Citalopram, ecitalopram, fluoxetine, sertraline, paroxetine IR, paroxetine CR, venlafaxine IR, venlafaxine XR (extended release), desvenlafaxine, duloxetine, mirtazapine,...” NCT02400346 ↗

“Drug: Antidepressant (citalopram, duloxetine, escitalopram, sertraline, or venlafaxine XR) + cariprazine (0.1-0.3 mg/d) Oral, once daily for 8 weeks following an 8 week...” NCT00854100 ↗

“The dose is 20-60mg/day for fluoxetine, 20-40mg/day for paroxetine, 100-300mg/day for fluvoxamine, 50-200mg/day for sertraline, 20-40mg/day for citalopram, 10-20mg/day for...” NCT05148169 ↗

“Participants will receive SSRI antidepressant (such as, citalopram, escitalopram, fluvoxamine, fluoxetine, paroxetine, sertraline, vilazodone or vortioxetine) as a part of...” NCT03321526 ↗

“Antidepressant medications may include any of the following: citalopram, escitalopram, paroxetine, sertraline, venlafaxine XR, bupropion SR, duloxetine, nortriptyline, and mirtazapine.” NCT00742573 ↗

“approved by the State Food and Drug Administration (CFDA) for the treatment of OCD (i.e., fluoxetine, paroxetine, sertraline and fluvoxamine) as well as citalopram and escitalopram” NCT05528224 ↗

Show 180 more sources

Known as Celexa “Participants receive only clinical routine antidepressant treatment,Which include fluoxetine (Prozac); sertraline (Zoloft); paroxetine (Paxil); citalopram (Celexa)...” NCT01831440 ↗
16

“Antidepressant medications may include the following: citalopram (Celexa), escitalopram (Lexapro), paroxetine (Paxil CR), sertraline (Zoloft), venlafaxine XR (Effexor XR),...” NCT00564278 ↗

“This study will evaluate the effectiveness of the stimulant medication methylphenidate (MPH, more commonly known as Ritalin ) when combined (or not combined) with the...” NCT00794040 ↗

“Throughout the study, all subjects will receive either escitalopram (Lexapro) or citalopram (Celexa) on the basis of the study doctor's clinical judgment.” NCT00361218 ↗

“METHOD: Effexor XR/Novo-venlafaxine XR 75 mg and Celexa/Gen-citalopram 40 mg were studied in a randomized crossover design.” PMID 19653973 ↗ Jul 2009

“This study will compare the safety and effectiveness two medications, citalopram (Celexa®) and risperidone (Risperdal®).” NCT00073658 ↗

“We will administer MDMA alone and in combination with the antidepressant citalopram (one trade name for this is Celexa).” NCT00838305 ↗

“antidepressant therapy with Celexa (Citalopram) in people suffering from Major Depressive Disorder.” NCT00067301 ↗

“Participants receive citalopram (Celexa) for 8 weeks and a placebo for 1 week.” NCT00047671 ↗

“Participants will take citalopram (Celexa)” NCT00047450 ↗

“citalopram hydrobromide (Celexa®) tablets” NCT03538691 ↗

Show 6 more sources

Known as CelexaTM “CelexaTM 40 mg tablets, single dose” NCT00865085 ↗
Known as cipralex “citalopram (cipralex)” NCT00532519 ↗
Known as Cipramil “50 patients with reflux hypersensitivity and 50 patients with functional heartburn will receive either placebo or citalopram (Cipramil®) 20 mg as an add-on for a period of 8 weeks.” NCT03499171 ↗
Known as CIT “OBJECTIVE: To confirm the efficacy of a targeted complicated grief treatment (CGT), determine whether citalopram (CIT) enhances CGT outcome, and examine CIT efficacy without CGT.” PMID 27276373 ↗ Jul 2016
1

“Pipamperone/Citalopram (PNB01) Versus Citalopram (CIT) and Versus Pipamperone (PIP) in Major Depressive Disorder (MDD)” NCT01312922 ↗

Known as citalopram (Celexa) “citalopram (Celexa)” NCT01460212 ↗
1

“Citalopram, Celexa” NCT01916824 ↗

Known as Citalopram Aurobindo “The medicinal product Citalopram Aurobindo contains citalopram as active ingredient available on the market in 20 mg film coated tablets. The tablets are divisible in two equal...” NCT04975724 ↗
Known as Citalopram HBr “Citalopram HBr eq. 10 mg tablets, single dose” NCT00865943 ↗
2

“Citalopram HBr 40 mg tablets, single dose” NCT00865085 ↗

“Citalopram HBr 40 mg tablets, single dose” NCT00864890 ↗

Known as Citalopram Hydrobromide “Citalopram Hydrobromide Tablets 40 mg: Test Product: Citalopram Hydrobromide Tablets 40 mg manufactured by Torrent Pharmaceuticals Limited, India” NCT00940238 ↗
5

“the control group was given citalopram hydrobromide combined with zolpidem” NCT06740188 ↗

“citalopram hydrobromide (Celexa®) tablets” NCT03538691 ↗

NCT00930293 ↗

NCT00363909 ↗

NCT00086645 ↗

Known as CTP “OBJECTIVE: Despite the clinical importance of chronic and severe irritability, there is a paucity of controlled trials for its pharmacological treatment. Here, we examine the...” PMID 31128268 ↗ May 2019
Known as Gen-Citalopram “METHOD: Effexor XR/Novo-venlafaxine XR 75 mg and Celexa/Gen-citalopram 40 mg were studied in a randomized crossover design.” PMID 19653973 ↗ Jul 2009
Action Inhibit “citalopram, a selective serotonin reuptake inhibitor (SSRI)” NCT00217828 ↗
Modality Small molecule “citalopram, another SSRI” NCT00834834 ↗
Route Oral “taken orally” NCT00048815 ↗