drugset
drugset / Trial / NCT00838305

Role of Serotonin in Acute and Subacute MDMA Effects

NCT00838305 ↗

Completed 13 enrolled California Pacific Medical Center Research Institute
RandomizedCrossoverDouble-blindBasic science

Summary

The purpose of this study is to measure the effects of MDMA (particularly its emotional effects) and to determine the role of serotonin in these effects. Serotonin is a neurotransmitter, which is a chemical that is released by some brain cells to communicate with other brain cells. Many of the effects of MDMA are thought to be the result of increased serotonin release. In order to understand the effects of MDMA and role of serotonin in these effects, we will administer MDMA alone and in combination with the antidepressant citalopram (one trade name for this is Celexa). Citalopram decreases the ability of MDMA to release serotonin. Citalopram will therefore decrease any of MDMA's effects that are the result of serotonin release; we want to measure this.

Timeline

Start
2009-02
Primary completion
2009-12
Completion
2011-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Citalopram Small molecule 20 mg —
Subject MDMA Unknown 1.5 mg/kg —

Indications

No indication recorded.