drugset / Trial / NCT00666757
A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to compare duloxetine with other antidepressants in the treatment of severe depression.
Timeline
- Start
- 2008-05
- Primary completion
- 2009-02
- Completion
- 2009-03
Publications
- Dodd S, Berk M, Kelin K, Zhang Q, Eriksson E, Deberdt W, Craig Nelson J. Application of the Gradient Boosted method in randomised clinical trials: Participant variables that contribute to depression treatment efficacy of duloxetine, SSRIs or placebo. J Affect Disord. 2014 Oct;168:284-93. doi: 10.1016/j.jad.2014.05.014. Epub 2014 Jun 4.
- Martinez JM, Katon W, Greist JH, Kroenke K, Thase ME, Meyers AL, Edwards SE, Marangell LB, Shoemaker S, Swindle R. A pragmatic 12-week, randomized trial of duloxetine versus generic selective serotonin-reuptake inhibitors in the treatment of adult outpatients in a moderate-to-severe depressive episode. Int Clin Psychopharmacol. 2012 Jan;27(1):17-26. doi: 10.1097/YIC.0b013e32834ce11b.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Citalopram | Small molecule | 20 mg | Oral |
| Comparator | Citalopram | Small molecule | 40 mg | Oral |
| Subject | Duloxetine | Small molecule | 30 mg | Oral |
| Subject | Duloxetine | Small molecule | 120 mg | Oral |
| Comparator | Fluoxetine | Small molecule | 20 mg | Oral |
| Comparator | Fluoxetine | Small molecule | 80 mg | Oral |
| Comparator | Paroxetine | Small molecule | 20 mg | Oral |
| Comparator | Paroxetine | Small molecule | 50 mg | Oral |
| Comparator | Sertraline | Small molecule | 50 mg | Oral |
| Comparator | Sertraline | Small molecule | 200 mg | Oral |