drugset / Trial / NCT00602290
Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression
Phase 4
Completed
181 enrolled
University of California, Los Angeles
National Institute of Mental Health (NIMH) · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study will evaluate the safety and effectiveness of methylphenidate in improving cognition and function in older adults with depression.
Timeline
- Start
- 2008-02
- Primary completion
- 2013-01
- Completion
- 2013-02
Publications
- Results Schneider B, Ercoli L, Siddarth P, Lavretsky H. Vascular burden and cognitive functioning in depressed older adults. Am J Geriatr Psychiatry. 2012 Aug;20(8):673-81. doi: 10.1097/JGP.0b013e31822ccd64.
- Eyre HA, Eskin A, Nelson SF, St Cyr NM, Siddarth P, Baune BT, Lavretsky H. Genomic predictors of remission to antidepressant treatment in geriatric depression using genome-wide expression analyses: a pilot study. Int J Geriatr Psychiatry. 2016 May;31(5):510-7. doi: 10.1002/gps.4356. Epub 2015 Oct 15.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Citalopram | Small molecule | 20 mg | — |
| Comparator | Citalopram | Small molecule | 60 mg | — |
| Comparator | Methylphenidate | Small molecule | 5 mg | — |
| Comparator | Methylphenidate | Small molecule | 40 mg | — |