Mechanism of tDCS-induced Learning Enhancement - the Role of Serotonin

NCT02092974 ↗

Phase 1 Completed 40 enrolled Charite University, Berlin, Germany

RandomizedCrossoverTriple-blindTreatment

Summary

The aim of this study is to assess whether the application of a selective serotonin reuptake inhibitor (SSRI) enhances and prolongs the learning enhancement achieved by anodal transcranial direct current stimulation (atDCS). For this, young and older healthy subjects will be tested with a well established learning paradigm. Results of this study may help to support the application of atDCS also in patients, e.g. with dementia or mild cognitive impairment.

Timeline

Start: 2014-04
Primary completion: 2014-12
Completion: 2014-12

Publications

Results Prehn K, Stengl H, Grittner U, Kosiolek R, Olschlager A, Weidemann A, Floel A. Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults. Neuropsychopharmacology. 2017 Jan;42(2):551-561. doi: 10.1038/npp.2016.170. Epub 2016 Aug 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Citalopram	Small molecule	20 mg	—

Indications

No indication recorded.