drugset / Trial / NCT02179268
Antidepressants and Bone Mineral Density
RandomizedSingle-groupOpen-labelSupportive care
Summary
The aim of this five arm randomized trial was thus to compare selective serotonin reuptake inhibitor (SSRI)sertraline and citalopram to a dual reuptake inhibitor venlafaxine, a nor-adrenaline reuptake inhibitor reboxetine and a control group receiving placebo, with the primary endpoint being bone mineral density, and secondary endpoints being bone turnover markers.
Timeline
- Start
- 2012-03
- Primary completion
- 2014-04
- Completion
- 2014-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Citalopram | Small molecule | 20 mg | Oral |
| Comparator | Reboxetine | Unknown | 4 mg | — |
| Comparator | Sertraline | Small molecule | 50 mg | — |
| Comparator | Venlafaxine | Small molecule | 25 mg | — |