DECIFER: Depression and Citalopram In First Episode Recovery

Summary

This study seeks to examine the effectiveness of citalopram added to treatment with any oral or injectable second-generation antipsychotic plus standardized psychoeducation in first episode schizophrenia patients. Because depressive symptoms are common in first episode patients, we will test the hypothesis that adding the SSRI citalopram to a pre-established medication regimen will improve quality of life and decrease relapse and suicidality over the course of a 12-month trial.

Timeline

Start

2010-01

Primary completion

2014-12

Completion

2018-03-26

Publications

• Wang J, Hart KL, Qi W, Ardekani BA, Li C, Marx J, Freudenreich O, Cather C, Holt D, Bello I, Diminich ED, Tang Y, Worthington M, Zeng B, Wu R, Fan X, Zhao J, Wang J, Goff DC. Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia. J Clin Psychopharmacol. 2021 May-Jun 01;41(3):244-249. doi: 10.1097/JCP.0000000000001391.

Drugs

Indications