Effects of Citalopram on Hostility and CHD Risk

Summary

To evaluate the therapeutic effects of the serotonergic agent, citalopram, on hostility and other behavioral risk factors, and biological markers of disease risk (serum lipids, insulin and glucose; autonomic balance and stress-related cardiovascular reactivity; platelet activation).

Timeline

Start

2002-03

Primary completion

2003-02

Completion

2003-02

Publications

• Rice E, Vize C, Manuck S, Kamarck T. Mood reactivity to daily social conflict in hostile adults: An experimental intervention. Health Psychol. 2025 May;44(5):436-445. doi: 10.1037/hea0001411.
• Kamarck TW, Muldoon MF, Manuck SB, Haskett RF, Cheong J, Flory JD, Vella E. Citalopram improves metabolic risk factors among high hostile adults: results of a placebo-controlled intervention. Psychoneuroendocrinology. 2011 Aug;36(7):1070-9. doi: 10.1016/j.psyneuen.2011.01.005. Epub 2011 Feb 8.

Drugs

Indications