Citalopram for Cocaine Dependence

Summary

This is a phase 2 clinical trial of citalopram pharmacotherapy for treatment of cocaine dependence. Using a double-blind, randomized controlled design, eligible cocaine dependent patients will be assigned equally to one of three medication conditions: placebo or the Selective serotonin re-uptake inhibitor (SSRI) agent, citalopram at either 20 mg per day or 40 mg per day. It is hypothesized that citalopram will reduce cocaine use and increase periods of sustained abstinence substantially more than placebo. Performance on a set of behavioral tasks of impulsivity will be analyzed as potential predictors of treatment response.

Timeline

Start

2010-12

Primary completion

2016-07

Completion

2016-07

Publications

• de Dios C, Suchting R, Green CE, Webber HE, Moeller FG, Lane SD, Schmitz J. The role of Iowa gambling task performance in response to citalopram treatment for cocaine use disorder. Am J Drug Alcohol Abuse. 2025 Jan 2;51(1):73-84. doi: 10.1080/00952990.2024.2420773. Epub 2025 Jan 24.

Drugs

Indications