Antidepressant Maintenance in Traumatic Brain Injury

Phase 4 Unknown 21 enrolled Ontario Neurotrauma Foundation

RandomizedSingle-groupQuadruple-blindTreatment

Summary

The purpose of the study is to explore to what extent continuing the antidepressant medication citalopram (Celexa), after depression has responded to treatment, helps prevent the return of depressive symptoms in patients with recent traumatic brain injury (TBI).

Timeline

Start: 2005-05
Primary completion: 2008-05
Completion: 2008-10

Outcome

Missed primary endpoint

paper The groups did not differ in relapse rates (drug: 50.0% [5/10] vs placebo: 54.5% [6/11], Fisher exact test, P = .835) PMID 20441723 ↗

Publications

Rapoport MJ, Mitchell RA, McCullagh S, Herrmann N, Chan F, Kiss A, Feinstein A, Lanctot KL. A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury. J Clin Psychiatry. 2010 Sep;71(9):1125-30. doi: 10.4088/JCP.09m05086blu. Epub 2010 Apr 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Citalopram	Small molecule	20 mg	—
Subject	Citalopram	Small molecule	40 mg	—