Effects of Single Dose Citalopram and Reboxetine on Urethral and Anal Closure Function on Healthy Female Subjects

Summary

This study will investigate if citalopram, a selective serotonin reuptake inhibitor, is reducing the opening pressure of the urethra and possibly causing or worsening stress urinary incontinence. Reboxetine, a norepinephrine reuptake inhibitor, is known to increase urethral opening pressure through actions on adrenoceptors in Onuf´s nucleus and will act as an active control. Furthermore, this study is performed to explore the effects of reboxetine and citalopram on the opening pressure of the anal canal.

Timeline

Start

2019-09-17

Primary completion

2020-02-01

Completion

2020-05-01

Publications

• Christoffersen T, Riis T, Sonne J, Kornholt J, Sonne DP, Klarskov N. Effect of reboxetine and citalopram on anal opening pressure in healthy women: A randomized, double-blind, placebo-controlled crossover study. Neurogastroenterol Motil. 2024 Oct;36(10):e14882. doi: 10.1111/nmo.14882. Epub 2024 Jul 30.

Drugs

Indications