drugset / Trial / NCT00118430
Stepped Care for Depression and Musculoskeletal Pain
Phase 4
Completed
500 enrolled
Indiana University
National Institute of Mental Health (NIMH) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This study will evaluate the effectiveness of a stepped care approach in treating depression and reducing pain.
Timeline
- Start
- 2004-09
- Primary completion
- 2008-07
- Completion
- 2008-08
Outcome
Met primary endpoint
registry analysis (superiority or other test); Stepped Care vs Usual Care; p <0.001; Mixed Models Analysis NCT00118430 ↗
registry analysis (superiority or other test); Stepped Care vs Usual Care; p < 0.001; Mixed Models Analysis NCT00118430 ↗
Publications
- Dube P, Kurt K, Bair MJ, Theobald D, Williams LS. The p4 screener: evaluation of a brief measure for assessing potential suicide risk in 2 randomized effectiveness trials of primary care and oncology patients. Prim Care Companion J Clin Psychiatry. 2010;12(6):PCC.10m00978. doi: 10.4088/PCC.10m00978blu.
- Kroenke K, Bair MJ, Damush TM, Wu J, Hoke S, Sutherland J, Tu W. Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial. JAMA. 2009 May 27;301(20):2099-110. doi: 10.1001/jama.2009.723.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Citalopram | Small molecule | 40 mg | — |
| Subject | Duloxetine | Small molecule | 120 mg | — |
| Subject | Fluoxetine | Small molecule | 40 mg | — |
| Subject | Nortriptyline | Small molecule | 75 mg | — |
| Subject | Paroxetine | Small molecule | 40 mg | — |
| Subject | Sertraline | Small molecule | 150 mg | — |
| Subject | Venlafaxine | Small molecule | 225 mg | — |