A Neuroimaging and Epigenetic Investigation of Antidepressants in Depression

Summary

The purpose of this study is: 1. to find out the structural or functional effects of selective serotonin reuptake inhibitors (SSRI) in major depressive disorder (MDD); 2. find special abnormalities in depression secondary to other disease, e.g., autoimmune disease like systemic lupus erythematosus (SLE). 3. find the relationship between the efficacy of antidepressant and the change of neuroimaging in MDD 4. to find possible predispose to MDD 5. to explore the DNA methylation status in depression;

Timeline

Start

2008-06

Primary completion

2011-06

Completion

2011-06

Publications

• Yang Y, Tao L, Zhao R, Bai R, Liu S, Zhang G, Li S, Xu X, Cheng Y, Xu J. Influence of sex and systemic lupus erythematosus disease status on cerebral cortex structure. Lupus Sci Med. 2026 Jun 25;13(1):e002032. doi: 10.1136/lupus-2026-002032.
• Chu Z, Yuan L, He M, Cheng Y, Lu Y, Xu X, Shen Z. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. 2023 Jun 7;34(10):493-500. doi: 10.1097/WNR.0000000000001915. Epub 2023 May 31.
• Cheng Y, Xu J, Yu H, Nie B, Li N, Luo C, Li H, Liu F, Bai Y, Shan B, Xu L, Xu X. Delineation of early and later adult onset depression by diffusion tensor imaging. PLoS One. 2014 Nov 13;9(11):e112307. doi: 10.1371/journal.pone.0112307. eCollection 2014.
• Xu J, Cheng Y, Chai P, Lu Z, Li H, Luo C, Li X, Li L, Zhou Q, Chen B, Cao J, Xu X, Shan B, Xu L, Wen J. White-matter volume reduction and the protective effect of immunosuppressive therapy in systemic lupus erythematosus patients with normal appearance by conventional magnetic resonance imaging. J Rheumatol. 2010 May;37(5):974-86. doi: 10.3899/jrheum.090967. Epub 2010 Mar 15.

Drugs

Indications