Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits

Summary

This study is designed to determine whether bupropion (vs escitalopram) increases functional connectivity (FC) within reward-related neurocircuits and decreases motivational deficits in depressed patients with increased inflammation and anhedonia. Participants will be randomized to take bupropion extended release (XL) or escitalopram for 8 weeks.

Timeline

Start

2020-09-23

Primary completion

2022-07-25

Completion

2022-07-25

Drugs

Indications