The Effect of SSRIs on Threat of Shock Potentiated Neural Circuitry

Summary

This study aims to increase the knowledge about psychological processes which may contribute to mental health problems such as depression and anxiety. This study aims to investigate if administering Escitalopram, an antidepressant which increases serotonin levels in parts of the brain, affects how the brain processes emotional information. It is hoped that measuring these changes will increase the understanding of processes involved in mental health problems.

Timeline

Start

2017-12-01

Primary completion

2022-06-30

Completion

2022-06-30

Publications

• Results Lukow PB, Lowther M, Pike AC, Yamamori Y, Chavanne AV, Gormley S, Aylward J, McCloud T, Goble T, Rodriguez-Sanchez J, Tuominen EW, Buehler SK, Kirk P, Robinson OJ. Amygdala activity after subchronic escitalopram administration in healthy volunteers: A pharmaco-functional magnetic resonance imaging study. J Psychopharmacol. 2024 Dec;38(12):1071-1082. doi: 10.1177/02698811241286773. Epub 2024 Oct 4.
• Lukow PB, Lowther M, Pike AC, Yamamori Y, Chavanne AV, Gormley S, Aylward J, Vera CE, McCloud T, Goble T, Rodriguez-Sanchez J, Tuominen EW, Buehler SK, Kirk P, Robinson OJ. Brain activation and connectivity after 2-3 weeks of escitalopram administration in anxiety disorders: A randomised trial. J Affect Disord. 2026 Feb 1;394(Pt B):120682. doi: 10.1016/j.jad.2025.120682. Epub 2025 Nov 13.

Drugs

Indications