Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disorder

Phase 3 Completed 101 enrolled H. Lundbeck A/S

RandomizedParallel-groupDouble-blindTreatment

Summary

This study aims at evaluating the effect of vortioxetine on cognitive dysfunction in major depressive disorder (MDD) patients with inadequate response to current antidepressant treatment.

Timeline

Start: 2014-12
Primary completion: 2016-03
Completion: 2016-03

Publications

Christensen MC, Sluth LB, McIntyre RS. Validation of the University of California San Diego Performance-based Skills Assessment (UPSA) in major depressive disorder: Replication and extension of initial findings. J Affect Disord. 2019 Feb 15;245:508-516. doi: 10.1016/j.jad.2018.11.034. Epub 2018 Nov 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Escitalopram	Small molecule	10 mg	Oral
Comparator	Escitalopram	Small molecule	20 mg	Oral
Subject	Vortioxetine	Unknown	10 mg	Oral
Subject	Vortioxetine	Unknown	20 mg	Oral

Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disorder

Summary

Timeline

Publications

Drugs

Indications