Lithium

also known as Lithium Carbonate · lithium aspartate · Lithium sulphate · Lithobid, lithium carbonate

targets BDNF, CDK5, GSK3B via activation / inhibition

Developed for: bipolar disorder · major depressive disorder · depressive disorder · bipolar depression · schizophrenia · bipolar I disorder · cognitive impairment with or without cerebellar ataxia · dementia
+27 more
· manic bipolar affective disorder · cognitive disorder · small cell lung carcinoma · Alzheimer disease · amyotrophic lateral sclerosis · bipolar II disorder · Canavan disease · cannabis dependence · colorectal neoplasm · conduct disorder · corticobasal degeneration disorder · gastric neoplasm · Huntington disease · long COVID-19 · medullary thyroid gland carcinoma · mental disorder · neoplasm of esophagus · neuroendocrine neoplasm · osteoporosis-pseudoglioma syndrome · Parkinson disease · progressive supranuclear palsy · schizoaffective disorder · substance withdrawal syndrome · acute kidney injury · mood disorder · psychotic disorder · spinal cord injury
Investigated by: National Institute of Mental Health (NIMH) · New York State Psychiatric Institute · AstraZeneca · National Institute of Neurological Disorders and Stroke (NINDS) · Nova Scotia Health Authority · Assistance Publique - Hôpitaux de Paris
+101 more
· Central South University · Dr. Inge Winter · Federal University of Rio Grande do Sul · Indiana University · Melbourne Health · National Institutes of Health (NIH) · State University of New York at Buffalo · University of Münster · University of Oxford · University of Sao Paulo · University of Wisconsin, Madison · Washington University School of Medicine · Aalborg University Hospital · Abbott · Agency for Healthcare Research and Quality (AHRQ) · Air Force Military Medical University, China · Angelini Pharma · Ariel Gildengers, MD · Barwon Health · Cancer Trials Ireland · CellPrint Biotechnology · Centre for Addiction and Mental Health · Children's Hospital Medical Center, Cincinnati · Chinese Academy of Sciences · Chonnam National University Hospital · Corning Hospital, Shenzhen City · Creighton University · Deakin University · Drexel University · Emory University · European Leukodystrophy Association · Ewha Womans University · Fight AIDS and Infectious Diseases Foundation · First Affiliated Hospital Xi'an Jiaotong University · First Affiliated Hospital of Kunming Medical University · German Federal Ministry of Education and Research · GlaxoSmithKline · Glostrup University Hospital, Copenhagen · Guiyun Xu · Hannover Medical School · Hospital de Clinicas de Porto Alegre · Icahn School of Medicine at Mount Sinai · James Murrough · K. Lieb · Karuna Therapeutics, Inc. · Keming Gao · Lawson, William B., M.D., PhD, DFAPA · Massachusetts General Hospital · Mediolanum Cardio Research · Mental Health Department Odense, University Clinic · National Alliance for Research on Schizophrenia and Depression · National Cancer Institute (NCI) · National Center for Advancing Translational Sciences (NCATS) · National Institute on Aging (NIA) · National Institute on Drug Abuse (NIDA) · Northwell Health · Patient-Centered Outcomes Research Institute · Peking University Sixth Hospital · Peter MacCallum Cancer Centre, Australia · Pfizer · Psychiatric Center Copenhagen, Rigshospitalet · Psychiatric Hospital, Hillerod · Rakitzi, Stavroula · Region Stockholm · Renmin Hospital of Wuhan University · Rigshospitalet, Denmark · Second Military Medical University · Seventh People's Hospital of Hangzhou · Shandong Mental Health Center · Shanghai Jiao Tong University School of Medicine · Shanghai Mental Health Center · Shanxi Medical University · Shire · Soon Chun Hyang University · all 107 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	LITHIUM CITRATE	—	1980-12-23	fda.gov ↗

Trials 80 · started per year

today

US approved 1980

1980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT05923476	Jun 2023 → May 2025	depressive disorder	Melbourne Health	Unknown	No outcome recorded
Phase 19 trials
Phase 1	NCT06993662	Jun 2025 → Dec 2027 expected	anxiety, bipolar disorder, depressive disorder, obsessive-compulsive disorder +3	Rakitzi, Stavroula	Active not recruiting	No outcome recorded
Phase 1	NCT06729970	Dec 2024 → Jan 2026	—	Karuna Therapeutics, Inc.	Completed	No outcome recorded
Phase 1	NCT03153280	Jan 2022 → Sep 2023	colorectal neoplasm, gastric neoplasm, neoplasm of esophagus	Cancer Trials Ireland	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT04273932	Oct 2019 → Jun 2023	Parkinson disease	State University of New York at Buffalo	Completed	No outcome recorded
Phase 1	NCT01565759	May 2012 → May 2023	disease by molecular mechanism	Nova Scotia Health Authority	Completed	No outcome recorded
Phase 1	NCT00820794	May → Jun 2009	generalized anxiety disorder	Pfizer	Withdrawn	No outcome recorded
Phase 1	NCT01074073	Aug → Oct 2008	schizophrenia	Sumitomo Pharma America, Inc.	Completed	No outcome recorded
Phase 1	NCT00548964	Oct 2007 → Jul 2013	major depressive disorder	James Murrough	Completed	No outcome recorded
Phase 1	NCT00563992	Jan 2001 → Sep 2008	bipolar disorder	New York State Psychiatric Institute	Completed	No outcome recorded
Phase 1/23 trials
Phase 1/2	NCT01553916	Apr 2012 → Sep 2016	small cell lung carcinoma	Washington University School of Medicine	Completed	No outcome recorded
Phase 1/2	NCT00703677	Sep 2008 → Jan 2010	corticobasal degeneration disorder, progressive supranuclear palsy	Westat	Completed	No outcome recorded
Phase 1/2	NCT00581009	May 2001 → Dec 2011	bipolar disorder, major depressive disorder	University of California, Irvine	Completed	No outcome recorded
Phase 211 trials · 1 missed
Phase 2	NCT06051240	Feb 2024 → Aug 2030 expected	brain neoplasm, cognitive disorder, radiation-induced disorder	Region Stockholm	Recruiting	No outcome recorded
Phase 2	NCT05618587	Nov 2022 → Jul 2023	long COVID-19	State University of New York at Buffalo	Completed	Missed primary
Phase 2	NCT01880593	Jul 2013 → Nov 2016	depressive disorder	Icahn School of Medicine at Mount Sinai	Completed	No outcome recorded
Phase 2	NCT01768767	Jan 2013	bipolar depression	Yale University	Withdrawn	No outcome recorded Stop: Business
Phase 2	NCT00657748	Sep 2009 → Sep 2010	Canavan disease, nutritional deficiency disease	Assistance Publique - Hôpitaux de Paris	Withdrawn	No outcome recorded
Phase 2	NCT00925847	Jun 2009 → Apr 2011	amyotrophic lateral sclerosis	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 2	NCT00582712	Jan 2008 → May 2009	medullary thyroid gland carcinoma	University of Wisconsin, Madison	Terminated	No outcome recorded Stop: Business
Phase 2	NCT00501540	Jul 2007 → Jun 2009	neuroendocrine neoplasm	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 2	NCT00114439	Sep 2005 → Sep 2006	cannabis dependence, substance withdrawal syndrome	Sydney South West Area Health Service	Completed	No outcome recorded
Phase 2	NCT00095355	Oct 2004 → Mar 2005	Huntington disease	National Institute of Neurological Disorders and Stroke (NINDS)	Completed	No outcome recorded
Phase 2	NCT00088387	Jul 2004 → Mar 2005	Alzheimer disease	National Institute of Neurological Disorders and Stroke (NINDS)	Completed	No outcome recorded

Phase 2/32 trials · 1 missed
Phase 2/3	NCT01928446	Jul 2015 → Aug 2019	bipolar disorder, depressive disorder	VA Office of Research and Development	Terminated	Missed primary
Phase 2/3	NCT00080158	Mar 2004 → Jun 2007	depressive disorder	New York State Psychiatric Institute	Completed	No outcome recorded
Phase 310 trials · 1 missed
Phase 3	NCT05603104	Apr 2025 → Jun 2028 expected	bipolar depression, major depressive disorder, schizophrenia	Dr. Inge Winter	Recruiting	No outcome recorded
Phase 3	NCT05973786	Feb 2025 → Jun 2028 expected	bipolar depression	Dr. Inge Winter	Recruiting	No outcome recorded
Phase 3	NCT02374567	Jan 2015 → Jun 2017	anxiety disorder, dementia, depressive disorder, schizophrenia +1	Hannover Medical School	Terminated	No outcome recorded
Phase 3	NCT00883493	Apr 2009 → Mar 2011	bipolar depression	AstraZeneca	Completed	No outcome recorded
Phase 3	NCT00400088	Jun 2007 → Jan 2013	major depressive disorder	Nova Scotia Health Authority	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00448578	Aug 2005 → Jun 2006	manic bipolar affective disorder	AstraZeneca	Completed	No outcome recorded
Phase 3	NCT00074776	May 2003 → Oct 2007	bipolar disorder	Stanford University	Completed	Missed primary
Phase 3	NCT00226135	Mar 2001 → Dec 2006	bipolar disorder	University of Aarhus	Completed	No outcome recorded
Phase 3	NCT00221429	Mar 2001 → Aug 2006	bipolar disorder	Children's Hospital Medical Center, Cincinnati	Completed	No outcome recorded
Phase 3	NCT00000385	Sep 1997 → Dec 2003	conduct disorder	Drexel University	Completed	No outcome recorded
Phase 434 trials · 1 met primary · 3 missed
Phase 4	NCT06662526	Nov 2024 → Nov 2029 expected	bipolar disorder, dementia, major depressive disorder	University of Chile	Not yet recruiting	No outcome recorded
Phase 4	NCT06184581	May 2024 → Dec 2027 expected	bipolar II disorder	University Hospital Bispebjerg and Frederiksberg	Recruiting	No outcome recorded
Phase 4	NCT05913947	Dec 2022 → Sep 2028 expected	bipolar depression	Aalborg University Hospital	Recruiting	No outcome recorded
Phase 4	NCT05531591	Aug 2019 → Jul 2024	cognitive impairment with or without cerebellar ataxia, dementia, major depressive disorder	Centre for Addiction and Mental Health	Completed	No outcome recorded
Phase 4	NCT03185208	Feb 2018 → Aug 2024	cognitive impairment with or without cerebellar ataxia	Ariel Gildengers, MD	Completed	No outcome recorded
Phase 4	NCT03219008	Aug 2017 → Dec 2019	major depressive disorder	Shanghai Mental Health Center	Unknown	Missed primary
Phase 4	NCT03210480	Mar 2017 → Sep 2019	bipolar disorder	Angelini Pharma	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT02960763	Feb 2017 → Sep 2020	major depressive disorder	Washington University School of Medicine	Completed	Mixed
Phase 4	NCT02909504	Sep 2016 → Nov 2018	bipolar disorder	Keming Gao	Terminated	No outcome recorded Stop: Business
Phase 4	NCT01543724	Jun 2015 → Dec 2017	bipolar disorder	Ewha Womans University	Withdrawn	No outcome recorded Stop: Enrollment
Phase 4	NCT01893229	Sep 2013 → Dec 2015	bipolar disorder	Guiyun Xu	Unknown	No outcome recorded
Phase 4	NCT01710163	Jun 2012 → Jun 2013	bipolar I disorder	University of Sao Paulo	Unknown	No outcome recorded
Phase 4	NCT01495156	Sep 2011 → Sep 2014	bipolar I disorder	Northwell Health	Withdrawn	No outcome recorded
Phase 4	NCT01416220	Sep 2011 → Feb 2013	major depressive disorder	Nova Scotia Health Authority	Withdrawn	No outcome recorded Stop: Enrollment
Phase 4	NCT01348282	May 2011 → Mar 2014	HIV infectious disease, cognitive disorder	Fight AIDS and Infectious Diseases Foundation	Completed	No outcome recorded
Phase 4	NCT01919892	Sep 2010 → Nov 2012	bipolar depression	University of Sao Paulo	Completed	No outcome recorded
Phase 4	NCT01331304	Sep 2010 → Apr 2013	bipolar disorder	Massachusetts General Hospital	Completed	Missed primary
Phase 4	NCT02901249	May 2010 → Nov 2014	major depressive disorder	Federal University of Rio Grande do Sul	Completed	No outcome recorded
Phase 4	NCT00974155	Sep 2009 → May 2014	major depressive disorder	K. Lieb	Completed	No outcome recorded
Phase 4	NCT00927550	Jun 2009 → Dec 2012	depressive disorder	University of Verona	Unknown	Missed primary
Phase 4	NCT00672490	Apr 2008 → Jul 2009	manic bipolar affective disorder	AstraZeneca	Completed	No outcome recorded
Phase 4	NCT01000402	Feb 2008 → Oct 2012	attention deficit-hyperactivity disorder, bipolar disorder	Federal University of Rio Grande do Sul	Unknown	No outcome recorded
Phase 4	NCT00596622	Aug 2007 → Jan 2012	bipolar disorder	Indiana University	Completed	No outcome recorded
Phase 4	NCT00608075	Apr 2007 → Jul 2015	bipolar I disorder	University of Cincinnati	Unknown	No outcome recorded
Phase 4	NCT01075126	Dec 2006	bipolar disorder	Lawson, William B., M.D., PhD, DFAPA	Withdrawn	No outcome recorded
Phase 4	NCT00325286	May 2006 → Mar 2008	bipolar disorder	Creighton University	Unknown	No outcome recorded
Phase 4	NCT00254488	Nov 2005 → Aug 2011	manic bipolar affective disorder	Weill Medical College of Cornell University	Completed	No outcome recorded
Phase 4	NCT00457054	Jul 2003 → Mar 2007	bipolar depression	Indiana University	Completed	No outcome recorded
Phase 4	NCT00202293	Oct 2001 → Nov 2015	bipolar disorder, schizoaffective disorder	Melbourne Health	Completed	No outcome recorded
Phase 4	NCT00021528	Jul 2001 → Sep 2006	major depressive disorder	National Institute of Mental Health (NIMH)	Completed	No outcome recorded
Phase 4	NCT00045916	Feb 2001 → Dec 2006	bipolar disorder, depressive disorder	New York State Psychiatric Institute	Completed	No outcome recorded
Phase 4	NCT00044616	Feb 2001 → Jan 2007	bipolar disorder, depressive disorder	University of Pennsylvania	Completed	Met primary
Phase 4	NCT00000375	Feb 1997 → ?	major depressive disorder	National Institute of Mental Health (NIMH)	Completed	No outcome recorded
Phase 4	NCT00870311	Mar 1996 → Apr 2004	bipolar disorder	Wayne State University	Completed	No outcome recorded

Phase not applicable10 trials
—	NCT06054321	Aug 2022 → Dec 2028 expected	major depressive disorder	Chonnam National University Hospital	Recruiting	No outcome recorded
—	NCT04218981	Jan 2020 → Jun 2023	mental disorder	Central South University	Completed	No outcome recorded
—	NCT02601859	Aug 2016 → Jun 2017	cognitive impairment with or without cerebellar ataxia	University of Dundee	Completed	No outcome recorded
—	NCT01486459	Nov 2012 → Aug 2014	small cell lung carcinoma	Barwon Health	Terminated	No outcome recorded Stop: Enrollment
—	NCT01880957	Nov 2011 → Jun 2017	bipolar depression, major depressive disorder	Stony Brook University	Completed	No outcome recorded
—	NCT03965247	Oct 2011 → Sep 2012	—	University of Oxford	Completed	No outcome recorded
—	NCT01431573	Jul 2011 → Aug 2016	bipolar disorder, major depressive disorder	New York State Psychiatric Institute	Completed	No outcome recorded
—	NCT01463111	May 2011 → Apr 2016	bipolar disorder	Emory University	Completed	No outcome recorded
—	NCT01108068	Jul 2010 → Jul 2014	osteoporosis-pseudoglioma syndrome	University of Maryland, Baltimore	Completed	No outcome recorded
—	NCT00012558	Sep 1998 → Sep 2005	bipolar disorder	National Institute of Mental Health (NIMH)	Completed	Mixed
Comparator or background therapy47 trials
Phase 1	NCT00437385 Background	Mar 2005 → Mar 2010	major depressive disorder	Charite University, Berlin, Germany	Completed	No outcome recorded
Phase 1/2	NCT01046786 Comparator	Jan 2010 → Oct 2013	spinal cord injury	China Spinal Cord Injury Network	Completed	No outcome recorded
Phase 1/2	NCT00612807 Background	Jul 2006 → Jun 2010	major depressive disorder	Duke University	Completed	No outcome recorded
Phase 2	NCT03290963 Comparator	Nov 2017 → Dec 2018	—	William V. Bobo, M.D.	Withdrawn	No outcome recorded
Phase 2	NCT02129348 Comparator	Jun 2014 → Jan 2020	Alzheimer disease, psychotic disorder	New York State Psychiatric Institute	Completed	No outcome recorded
Phase 2/3	NCT01166425 Comparator	Jun 2010 → Apr 2013	bipolar I disorder	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Completed	No outcome recorded
Phase 3	NCT06929273 Background	Jul 2025 → Jun 2028 expected	bipolar I disorder	Bristol-Myers Squibb	Recruiting	No outcome recorded
Phase 3	NCT00857584 Background	May 2009 → Feb 2011	bipolar depression	AstraZeneca	Completed	No outcome recorded
Phase 3	NCT00868452 Comparator	Apr 2009 → Dec 2011	bipolar depression	Sumitomo Pharma America, Inc.	Completed	Met primary
Phase 3	NCT00665366 Comparator	Jun 2008 → Oct 2011	manic bipolar affective disorder	Otsuka Pharmaceutical Development & Commercialization, Inc.	Completed	No outcome recorded
Phase 3	NCT00114686 Background	Jan 2006 → Apr 2007	alcohol dependence, bipolar I disorder	AstraZeneca	Completed	No outcome recorded
Phase 3	NCT00266630 Background	Nov 2005 → May 2009	manic bipolar affective disorder	Eli Lilly and Company	Completed	No outcome recorded
Phase 3	NCT00183443 Comparator	Feb 2005 → Nov 2010	bipolar disorder, schizophrenia	Palo Alto Veterans Institute for Research	Completed	No outcome recorded
Phase 3	NCT00107731 Background	Apr 2004 → Oct 2006	bipolar I disorder	AstraZeneca	Completed	Met primary
Phase 3	NCT00081380 Background	Mar 2004 → Sep 2006	bipolar disorder	AstraZeneca	Completed	Met primary
Phase 3	NCT01977300 Background	Jan 2003 → Aug 2011	bipolar I disorder	University of British Columbia	Completed	No outcome recorded
Phase 3	NCT00221975 Comparator	Jul 2002 → Jun 2007	bipolar disorder	University Hospitals Cleveland Medical Center	Completed	No outcome recorded
Phase 3	NCT00063362 Background	Feb 2002 → Jul 2007	bipolar disorder	University Hospitals Cleveland Medical Center	Terminated	No outcome recorded Stop: Business
Phase 3	NCT00194129 Background	Nov 1997 → Sep 2006	bipolar disorder	University Hospitals Cleveland Medical Center	Completed	Missed primary
Phase 3	NCT00518947 Comparator	Nov 1994 → Jun 1999	manic bipolar affective disorder	University of Pittsburgh	Completed	No outcome recorded
Phase 4	NCT07047651 Background	Jun 2025 → Dec 2027 expected	treatment-refractory schizophrenia	Dr. Stavroula Rakitzi	Active not recruiting	No outcome recorded
Phase 4	NCT03056248 Comparator	Apr → Dec 2017	acute kidney injury	Lifespan	Unknown	No outcome recorded
Phase 4	NCT03004521 Comparator	Nov 2016 → Apr 2021	mood disorder	King's College London	Unknown	No outcome recorded
Phase 4	NCT02287259 Comparator	Nov 2014 → Mar 2019	bipolar disorder	Tadashi Hasegawa	Completed	No outcome recorded
Phase 4	NCT01938859 Background	Jun 2012 → Dec 2017	bipolar disorder	Shanghai Mental Health Center	Unknown	No outcome recorded
Phase 4	NCT01526148 Comparator	Jan 2012 → Jan 2015	bipolar disorder	University Hospitals Cleveland Medical Center	Terminated	No outcome recorded Stop: Business
Phase 4	NCT01588457 Comparator	Jun 2011 → Dec 2016	bipolar I disorder, bipolar II disorder	The University of Texas Health Science Center at San Antonio	Completed	No outcome recorded
Phase 4	NCT01254721 Comparator	Dec 2010 → Oct 2012	manic bipolar affective disorder	AstraZeneca	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT01134731 Comparator	May 2010 → Feb 2014	major depressive disorder	University of Alabama at Birmingham	Completed	No outcome recorded
Phase 4	NCT02870283 Comparator	May 2010 → Nov 2014	bipolar disorder	Federal University of Rio Grande do Sul	Completed	No outcome recorded
Phase 4	NCT01028508 Comparator	Jan 2010 → Sep 2015	depressive disorder	Icahn School of Medicine at Mount Sinai	Completed	No outcome recorded
Phase 4	NCT00961961 Background	Jul 2009 → Sep 2016	bipolar disorder	University of Pennsylvania	Completed	No outcome recorded
Phase 4	NCT01305707 Comparator	Jul 2009 → Jul 2014	major depressive disorder	Hospital Universitari de Bellvitge	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT00931723 Comparator	Jun 2009 → Nov 2010	manic bipolar affective disorder	AstraZeneca	Completed	No outcome recorded
Phase 4	NCT00926835 Comparator	May 2009 → May 2015	major depressive disorder	Ministry of Health & Welfare, Korea	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT00976794 Background	Jan 2009 → Jun 2012	bipolar I disorder	University of Sao Paulo	Completed	Missed primary
Phase 4	NCT00627887 Background	Jan 2008 → May 2012	major depressive disorder	Örebro County Council	Completed	No outcome recorded
Phase 4	NCT00602537 Comparator	Dec 2007 → Jun 2013	bipolar disorder, depressive disorder	University of Pennsylvania	Completed	No outcome recorded
Phase 4	NCT00261443 Background	Sep 2005 → Jun 2009	bipolar disorder	Otsuka Pharmaceutical Development & Commercialization, Inc.	Completed	Met primary
Phase 4	NCT01191918 Comparator	May 2005 → Apr 2008	manic bipolar affective disorder	Shanghai Mental Health Center	Completed	No outcome recorded
Phase 4	NCT00048802 Background	Aug 2002 → Aug 2006	bipolar disorder	Northwell Health	Completed	No outcome recorded
—	NCT06467474 Background	Mar 2024 → Jun 2025 overdue	major depressive disorder	Ricardo Alberto Moreno, M.D., Ph.D.	Recruiting	No outcome recorded
—	NCT06751875 Comparator	Jul 2019 → Dec 2024	major depressive disorder	University of Antwerp	Completed	No outcome recorded
—	NCT02039479 Comparator	Jan 2014 → Mar 2018	depressive disorder	Technical University Dresden	Unknown	No outcome recorded
—	NCT01896349 Background	Apr 2013 → Aug 2014	—	Hospital de Clinicas de Porto Alegre	Unknown	No outcome recorded
—	NCT00893581 Comparator	Mar 2009 → Feb 2016	manic bipolar affective disorder	University of Cincinnati	Completed	No outcome recorded
—	NCT00520026 Comparator	Jan 2001 → Jun 2006	depressive disorder	University Hospital Schleswig-Holstein	Terminated	No outcome recorded Stop: Enrollment

Press releases naming this drug 3 releases

Date	Issuer	Release
2011-02-18	Otsuka Pharmaceutical Development & Commercialization, Inc.	ABILIFY (aripiprazole) Approved for Maintenance Treatment of Bipolar I Disorder as an Adjunct to Either Lithium or ValproateData from 52-week maintenance trial showed superiority of adjunctive ABILIFY versus adjunctive placebo on primary study endpoint® otsuka.co.jp ↗
2011-02-17	Bristol-Myers Squibb	ABILIFY® (aripiprazole) Approved for Maintenance Treatment of Bipolar I Disorder as an Adjunct to Either Lithium or Valproate bms.com ↗
2008-05-08	Bristol-Myers Squibb	U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for Add-On Treatment to Lithium or Valproate in the Acute Treatment of Adults With Manic and Mixed Episodes of Bipolar I Disorder With or Without Psychotic Features bms.com ↗

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 128 sources stand behind the page.

Field	Value	Cited text
Known as	Lithium	“The combination of pharmacotherapy (anxiolytics (Tavor, clonotril, lexotanil) antidepressants (SSRI, SNRI), mood stabilizers (lithium, depakine), antipsychotics (clozapine and...” NCT06993662 ↗ 126 “An adequate mood stabilizer treatment with lithium or valproate(defined as a serum concentration of 0.5-1.2 mEq/L or 50-100 microg/ml, respectively).” NCT00857584 ↗ “Lithium 300 mg capsules administered orally as two capsules (600 mg) twice a day (BID).” NCT01074073 ↗ “300 mg lithium, oral, once initially and then again at day 4 of PD 0332334 treatment” NCT00820794 ↗ “In case of relapse Bupropion, Quetiapine, Lithium or Aripiprazole might be add-on.” NCT06467474 ↗ “Lithium (according to response, serum levels, and tolerance) 150-1500mg” NCT01000402 ↗ “Choose lithium or valproate for bipolar disorder group” NCT04218981 ↗ “augmentation with mood stabilizer (lithium)” NCT06054321 ↗ “Lithium: 200-1200 mg/d. 905AN01” NCT01305707 ↗ “Lithium” NCT03056248 ↗ NCT00254488 ↗ Show 116 more sources
Known as	lithium aspartate	“INTERVENTION: Lithium aspartate, 10 to 15 mg/d, or identically appearing placebo for 3 weeks followed by open-label lithium aspartate, 10 to 15 mg/d, for 2 weeks.” PMID 39356507 ↗ Oct 2024
Known as	Lithium Carbonate	“Drug: Lithium Carbonate” NCT00602537 ↗ 3 “Drug: Lithium Carbonate” NCT01565759 ↗ “Drug: Lithium Carbonate” NCT00501540 ↗ “Drug: Lithium Carbonate” NCT00870311 ↗
Known as	Lithium sulphate	ClinicalTrials.gov intervention name — accepted as the source's own label NCT03210480 ↗
Known as	Lithobid, lithium carbonate	“Lithobid, lithium carbonate” NCT01431573 ↗
Action	Activate	“It is hypothesized that at safe and tolerable doses these drugs will enhance depleted levels of brain-derived neurotrophic factor (BDNF)” NCT00095355 ↗
Route	Oral	“Tablets, Oral, once daily” NCT00261443 ↗
Target	BDNF	“Lithium carbonate, a drug used to treat bipolar disorder, and divalproex, a drug used to treat mood disorders and seizure disorders, have both been shown to increase the amount...” NCT00095355 ↗