Neural Correlates for Therapeutic Mechanisms of Lithium in Bipolar Disorder

Summary

The investigators will assess Li-induced gray matter volume changes with regard to the endophenotype of GSK3beta polymorphism. The changes of gray matter are supposed to be more attributable to neurotrophic and neuroprotective characteristics of Li, which were closely related to the inhibition of apoptotic activity of GSK3beta.

Timeline

Start

2015-06-01

Primary completion

2017-12-31

Completion

2017-12-31

Drugs

Indications