drugset / Trial / NCT05531591
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
Phase 4
Completed
87 enrolled
Centre for Addiction and Mental Health
National Institute of Mental Health (NIMH) · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function.
Timeline
- Start
- 2019-08-01
- Primary completion
- 2024-07-31
- Completion
- 2024-07-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aripiprazole | Other / unclassified | 15 mg | — |
| Subject | Bupropion | Small molecule | 300 mg | — |
| Subject | Lithium | Unknown | 300 mg | — |
| Subject | Nortriptyline | Small molecule | 1 mg/kg | — |