drugset / Trial / NCT00457366
A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room
RandomizedParallel-groupSingle-blindTreatment
Summary
In the Psychiatric Emergency Room, agitated patients are treated routinely with an I.M. Haloperidol "cocktail" (Haloperidol 5 mg, Lorazepam 2 mg, Cogentin 2 mg), which has proved to be an effective treatment. However, since it is an intramuscular injection, it is more complicated and perhaps less acceptable to patients as well as more likely to cause EPS (extrapyramidal symptoms). Of late in our emergency room, we started using high dose Quetiapine 300 mg PO to replace the "cocktail" for treating agitation. It has shown promising results.
Timeline
- Start
- 2006-05
- Primary completion
- 2008-08
- Completion
- 2009-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Benztropine | Small molecule | 2 mg | Intramuscular |
| Comparator | Haloperidol | Other / unclassified | 5 mg | Intramuscular |
| Comparator | Lorazepam | Small molecule | 2 mg | Intramuscular |
| Comparator | Quetiapine | Small molecule | 300 mg | Oral |
Indications
No indication recorded.