Drugs / Haloperidol
last change Jun 2026 re-read 2 minutes ago

Haloperidol

Other / unclassified targets DRD2, HTR2A via inhibition

Developed for
delirium · schizophrenia · psychotic disorder · Alzheimer disease · cannabinoid hyperemesis syndrome · cannabis dependence · chronic pain syndrome · gastroparesis
+13 more · glioblastoma · Huntington disease · hyperlipidemia · mental disorder · migraine disorder · schizoaffective disorder · subacute delirium · bipolar disorder · bipolar I disorder · cyclic vomiting syndrome · female reproductive system disorder · headache disorder · mood disorder
Investigated by
National Cancer Institute (NCI) · German Research Network On Schizophrenia · Heinrich-Heine University, Duesseldorf · Janssen-Cilag Ltd. · M.D. Anderson Cancer Center · Mainz University
+87 more · Martin-Luther-University Halle-Wittenberg · National Institute on Aging (NIA) · RWTH Aachen University · University Hospital Tuebingen · University of Cologne · University of Duisburg-Essen · University of Göttingen · University of Jena · University of Mannheim · University of Wuerzburg · American Cancer Society, Inc. · Canadian Institutes of Health Research (CIHR) · Centre for Addiction and Mental Health · Eli Lilly and Company · German Federal Ministry of Education and Research · Humboldt-Universität zu Berlin · Indiana University · Ludwig-Maximilians - University of Munich · University of Bonn · Virginia Commonwealth University · Western Michigan University School of Medicine · Ain Shams University · Alberta Health services · Beersheva Mental Health Center · Beijing HuiLongGuan Hospital · Bristol-Myers Squibb · Bronson Methodist Hospital · Canadian Psychiatric Research Foundation · Cancer Prevention Research Institute of Texas · Case Western Reserve University · Catholic Health East · Centre for Research in Intensive Care (CRIC) · Christian Medical College, Vellore, India · Copenhagen Trial Unit, Center for Clinical Intervention Research · Demensforbundet, Norway · Denver Health Medical Center · Department of Psychiatry University FU Berlin · Department of Psychiatry University of Bonn · Dr. Marco L.A. Sivilotti · Dutch Diabetes Research Foundation · Fundacion Clinic per a la Recerca Biomédica · Fundación Pública Andaluza Progreso y Salud · HCA Hospice Care · Hannover Medical School · Hennepin Healthcare Research Institute · Hospital Clinic of Barcelona · Innlandet Hospital Trust · Instituto de Salud Carlos III · Juntendo University · King's College London · Leiden University Medical Center · Mario Negri Institute for Pharmacological Research · Medical Research Council · Michelle Weckmann · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Medical Sciences and Nutrition Salvador Zubiran · National Institute of Nursing Research (NINR) · National Institute on Drug Abuse (NIDA) · National Institutes of Health (NIH) · Northeastern University · OhioHealth · Quebec Firefighters Foundation for Burns · Radboud University Medical Center · Rully Riyandika · Sant Pau Research Institute · Scandinavian Critical Care Trials Group · Second Affiliated Hospital, School of Medicine, Zhejiang University · Southern Medical University, China · Technical University of Munich · Tehran University of Medical Sciences · The Danish Centre of Applied Social Science (VIVE) · The Physicians' Services Incorporated Foundation · The University of Texas Health Science Center, Houston · UMC Utrecht · all 93 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) HALDOL 1967-04-12 fda.gov

Trials 57 · a red edge is where a trial was stopped

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT04071639 Mar 2020 → Dec 2024 Huntington disease Second Affiliated Hospital, School of Medicine, Zhejiang University Unknown No outcome recorded
Phase 1 NCT03754062 Jun 2017 → Sep 2019 King's College London Completed No outcome recorded
Phase 1 NCT01924468 Aug 2013 → Sep 2018 nicotine dependence National Institute on Drug Abuse (NIDA) Completed No outcome recorded
Phase 1 NCT01259973 Feb → Nov 2011 Hospital Clinic of Barcelona Unknown No outcome recorded
Phase 23 trials
Phase 2 NCT06218524 Dec 2024 → Dec 2027 expected glioblastoma Southern Medical University, China Not yet recruiting No outcome recorded
Phase 2 NCT04750395 Sep 2021 → May 2024 delirium HCA Hospice Care Unknown No outcome recorded
Phase 2 NCT00429676 Dec 2005 → Sep 2007 delirium University of Colorado, Denver Completed No outcome recorded
Phase 2/34 trials
Phase 2/3 NCT06168773 Nov 2022 → Oct 2023 delirium Ain Shams University Completed No outcome recorded
Phase 2/3 NCT05431595 Jul 2022 → Feb 2027 expected delirium, epilepsy M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 2/3 NCT03743649 Jul 2019 → Dec 2028 expected delirium, high grade malignant neoplasm, metastatic malignant neoplasm M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 2/3 NCT03021486 Jun 2017 → Jun 2021 overdue delirium, metastatic malignant neoplasm M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 312 trials
Phase 3 NCT02345902 Jan 2016 → Mar 2018 delirium National Institute of Medical Sciences and Nutrition Salvador Zubiran Unknown No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT01811459 Feb 2013 → Sep 2016 delirium University of Montreal Hospital Centre (CHUM) Completed No outcome recorded
Phase 3 NCT01765829 Nov 2012 → Nov 2015 psychotic disorder Fundación Pública Andaluza Progreso y Salud Unknown No outcome recorded
Phase 3 NCT01211522 Dec 2011 → Aug 2017 delirium, mental disorder Vanderbilt University Medical Center Completed No outcome recorded
Phase 3 NCT00599287 Feb → May 2008 delirium UMC Utrecht Terminated No outcome recorded
Phase 3 NCT00300391 Mar 2006 → Oct 2011 delirium University of Pittsburgh Terminated No outcome recorded
Phase 3 NCT00455234 Sep 2005 → Jul 2006 psychotic disorder Christian Medical College, Vellore, India Completed No outcome recorded
Phase 3 NCT00124930 May 2005 → Jun 2008 cancer or benign tumor Alberta Health services Terminated No outcome recorded
Phase 3 NCT00485901 Jul 2004 → Jan 2005 schizophrenia Eli Lilly and Company Completed No outcome recorded
Phase 423 trials
Phase 4 NCT07109245 Dec 2025 → Aug 2028 expected acute insulin response Centre for Addiction and Mental Health Recruiting No outcome recorded
Phase 4 NCT06395428 Jul 2024 → Apr 2025 overdue chronic pain syndrome Western Michigan University School of Medicine Recruiting No outcome recorded
Phase 4 NCT04764344 Apr 2021 → May 2023 Western Michigan University School of Medicine Completed No outcome recorded
Phase 4 NCT04176055 Oct 2020 → Jun 2021 cannabinoid hyperemesis syndrome University of Calgary Completed No outcome recorded
Phase 4 NCT03392376 Jun 2018 → Jul 2022 delirium Zealand University Hospital Unknown No outcome recorded
Phase 4 NCT03199950 Jun 2017 → Nov 2018 delirium Zuyderland Medical Center Unknown No outcome recorded
Phase 4 NCT03056482 May 2017 → Jun 2019 cannabis dependence Dr. Marco L.A. Sivilotti Completed No outcome recorded
Phase 4 NCT02909465 Jul 2016 → Apr 2017 Tehran University of Medical Sciences Completed No outcome recorded
Phase 4 NCT02307396 Feb 2015 → Jun 2016 schizoaffective disorder, schizophrenia Technical University of Munich Completed No outcome recorded
Phase 4 NCT02103881 Apr → Jun 2014 Hennepin Healthcare Research Institute Withdrawn No outcome recorded
Phase not applicable11 trials
NCT07087925 Jan → Apr 2025 Rully Riyandika Completed No outcome recorded
NCT02192723 Jun 2012 → Jun 2014 schizophrenia Beijing HuiLongGuan Hospital Completed No outcome recorded
NCT01556932 Mar 2012 → May 2013 Virginia Commonwealth University Completed No outcome recorded
NCT01501123 Nov 2011 → Oct 2015 Catholic Health East Completed No outcome recorded
NCT03019887 Apr 2011 → Jan 2017 schizophrenia Juntendo University Completed No outcome recorded
NCT01204255 Nov 2010 → Apr 2011 Virginia Commonwealth University Completed No outcome recorded
NCT01152697 Jun 2010 → Aug 2012 University Hospitals Cleveland Medical Center Completed No outcome recorded
NCT00842608 Feb 2009 → Jul 2015 delirium Indiana University Completed No outcome recorded
NCT00493233 Nov 2006 → Dec 2008 schizophrenia Centre for Addiction and Mental Health Completed No outcome recorded
NCT00625014 Mar → Jul 2005 hyperlipidemia Leiden University Medical Center Completed No outcome recorded
Also used as a comparator or background therapy in 79 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT01684969 Comparator Mar 2012 → May 2013 Eric E. Prommer Withdrawn No outcome recorded
Phase 11 trial
Phase 1 NCT01193621 Comparator Jan 2008 → Jul 2010 Asan Medical Center Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02240173 Comparator Jun → Dec 2017 schizophrenia Federal Neuro-Psychiatric Hospital, Yaba Unknown No outcome recorded
Phase 210 trials
Phase 2 NCT06428084 Comparator Nov 2023 → Feb 2024 gallbladder disorder Padjadjaran University Completed No outcome recorded
Phase 2 NCT04715230 Comparator Jun 2021 → Oct 2022 methamphetamine-induced psychosis InterveXion Therapeutics, LLC Terminated No outcome recorded
Phase 2 NCT04529226 Comparator Nov 2020 → Jan 2025 intellectual disability, psychotic disorder Andalusian Public Foundation for Health Research in Seville Unknown No outcome recorded
Phase 2 NCT03375671 Comparator May 2018 → Mar 2020 David Barbic Completed No outcome recorded
Phase 2 NCT01323205 Background May 2011 → Nov 2012 schizophrenia Janssen Research & Development, LLC Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT00866645 Comparator Feb 2009 → Jul 2010 Shanghai Mental Health Center Completed No outcome recorded
Phase 2/3 NCT00340379 Comparator Apr 2003 → Aug 2005 mood disorder Duke University Completed No outcome recorded
Phase 321 trials
Phase 3 NCT07246187 Comparator Nov 2025 → Oct 2026 expected cannabinoid hyperemesis syndrome Mercy Bon Secours Saint Vincent Medical Center Recruiting No outcome recorded
Phase 3 NCT06370442 Comparator Jun 2024 → May 2025 mental disorder State University of New York - Upstate Medical University Unknown No outcome recorded
Phase 3 NCT05690698 Comparator Apr → Jul 2023 delirium Alexandria University Completed No outcome recorded
Phase 3 NCT05803642 Comparator Mar 2023 → May 2024 Qilu Pharmaceutical Co., Ltd. Unknown No outcome recorded
Phase 3 NCT04833023 Comparator May 2022 → Dec 2024 delirium Tan Tock Seng Hospital Unknown No outcome recorded
Phase 429 trials
Phase 4 NCT05246631 Comparator Jan → Mar 2020 Indonesia University Completed No outcome recorded
Phase 4 NCT03639558 Comparator Aug 2018 → Jul 2019 Joseph Dib Completed No outcome recorded
Phase 4 NCT03110900 Comparator Sep 2017 → Apr 2018 University of Arkansas Terminated No outcome recorded
Phase 4 NCT03246620 Comparator Sep 2017 → Jun 2018 The University of Hong Kong Terminated No outcome recorded
Phase 4 NCT03075657 Comparator May 2017 → Jun 2018 schizophrenia All India Institute of Medical Sciences, Bhubaneswar Completed No outcome recorded
Phase not applicable14 trials
NCT06993194 Comparator Jun 2025 → Jun 2026 overdue delirium, traumatic brain injury Benha University Not yet recruiting No outcome recorded
NCT06014606 Comparator Mar 2021 → Apr 2023 Maastricht University Completed No outcome recorded
NCT02625181 Background Jul 2016 → Nov 2017 Vanderbilt University Completed No outcome recorded
NCT01639599 Comparator Mar → Dec 2012 female reproductive system disorder The Catholic University of Korea Completed No outcome recorded
NCT01539733 Comparator Mar 2010 → Apr 2017 cancer of unknown primary site, delirium Amsterdam UMC, location VUmc Completed No outcome recorded

Evidence & citations 29 cited values

Every value below carries the sentence it was read from. 138 sources stand behind the page.

FieldValueCited text
Known as haloperidol “Regular antipsychotic medications (Risperidone, Olanzapine, Clozapine, Amisulpride, Quetiapine, Paliperidone, Aripiprazole, Haloperidol, Levomepromazine, Zuclopenthixol...” NCT01323205
131

“Drugs: Aripiprazole, Olanzapine, Zuclopenthixol, Clotiapine, Flupentixol, Risperidone, Sulpiride, Trifluoperazine, Haloperidol, Quetiapine, Paliperidone, Chlorpromazine,...” NCT01765829

“In case of early signs of a relapse prodrome based early intervention with an antipsychotic drug (Haloperidol, Risperidone and other) vs. benzodiazepine (Lorazepam) was applied...” NCT00159133

“Patients randomized to oral comparator arm will receive oral antipsychotics (haloperidol, paliperidone ER, risperidone, olanzapine, quetiapine or aripiprazole) as per...” NCT01081769

“The investigators aim to study the effectiveness of Haloperidol compared with Olanzapine in the management of hyperactive delirium in advanced cancer or end-stage organ disease...” NCT04833023

“A Randomized Double-blind, Parallel Group Study Comparing Olanzapine (Zyprexa) With Haloperidol (Novo-peridol) for the Relief of Nausea and Vomiting in Patients With Advanced Cancer” NCT00124930

“Patients received blindly olanzapine (5-20 mg/day; N=105), haloperidol (2.5-10 mg/day; N=20), or placebo (N=99) for 3 weeks.” PMID 22134043 Nov 2011

Haloperidol (6\~20mg/day) and perphenazine (16\~64mg/day), twice per day, 8 weeks” NCT02192723

“ * Levomepromazine * Haloperidol Anti-emetic for nausea” NCT02009306

“-4mg dexamethasone, 1mg haloperidol, scopolamine patch” NCT04081545

Haloperidol 2,5-10 mg; chlorpromazine 25-600 mg.” NCT01016145

“Drug: HaloperidolNCT06370442

haloperidolNCT05246631

NCT00340379

NCT02103881

NCT00797277

NCT01501123

NCT01639599

NCT03246620

NCT00485901

NCT01174290

NCT01556932

NCT03375671

NCT02380118

NCT04750395

NCT02057549

NCT04764344

NCT03743649

NCT06168773

NCT07246187

NCT01052389

NCT05803642

NCT06993194

NCT00534183

NCT01211522

NCT02374567

NCT00693472

NCT00189995

NCT00429676

NCT01193166

NCT02307396

NCT00615797

NCT03019887

NCT02143531

NCT01204255

NCT06428084

NCT01164059

NCT00723606

NCT00631722

NCT03075657

NCT00838032

NCT02203786

NCT00000179

NCT05690698

NCT02431702

NCT00866645

NCT02972502

NCT06395428

NCT02625181

NCT00159081

NCT01485692

NCT01924468

NCT00599287

NCT00253110

NCT00457366

NCT03754062

NCT03628391

NCT00044044

NCT01152697

NCT01259973

NCT02213900

NCT01140529

NCT04715230

NCT00842608

NCT00007774

NCT01785290

NCT04529226

NCT01539733

NCT01193621

NCT06218524

NCT05431595

NCT02343575

NCT00191555

NCT00954603

NCT00767715

NCT02098499

NCT03056482

NCT01123408

NCT00505804

NCT00625014

NCT07087925

NCT03199950

NCT00642369

NCT00156065

NCT00455234

NCT01684969

NCT00156104

NCT02199743

NCT02345902

NCT00169091

NCT01750541

NCT02433041

NCT04071639

NCT02493192

NCT05246631

NCT04176055

NCT00018850

NCT00625170

NCT00753051

NCT00096863

NCT00157378

NCT01811459

NCT00859872

NCT03392376

NCT02240173

NCT01530308

NCT00833300

NCT07109245

NCT00250237

NCT06014606

NCT03110900

NCT02747511

NCT02909465

NCT03021486

NCT05065567

NCT01161277

NCT00009217

NCT01862302

NCT00419653

NCT00097266

NCT00300391

NCT03639558

Known as 18F-haloperidol “Intravenous 18F haloperidol(10 mCi)” NCT01193621
Known as [19F]-HALOPERIDOL ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Dolpin ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Dozic ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Fortunan ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as HAL “The role of dopamine (DA) was assessed by pre-treating participants with the D2 receptor (D2R)-preferring antagonist, haloperidol (HAL; 3-mg) or mixed D1R-D2R antagonist,...” PMID 36919514 Mar 2023
Known as Haldol “The purpose of this study is to compare the efficacy and safety of Haldol (haloperidol) and olanzapine in the control of chronic nausea with advanced cancer patients who have...” NCT00124930
3

Haldol 5mg/ Ativan 2mg IM” NCT00786318

NCT00493233

NCT03489551

Known as Haldol solutab ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Haloperidol component of vesalium ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Haloperidol decanoate impurity, haloperidol- ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as HALOPERIDOL HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Haloperidol Injection “Drug: Haloperidol InjectionNCT06168773
Known as Haloperidol Tables, H31021234 Haloperidol Tables, H31021234NCT04071639
Known as Haloperidole ClinicalTrials.gov intervention name — accepted as the source's own label NCT00433121
1

NCT01157351

Known as Kentace ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Keselen ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as MCN-JR-1625 ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Novo-peridol “A Randomized Double-blind, Parallel Group Study Comparing Olanzapine (Zyprexa) With Haloperidol (Novo-peridol) for the Relief of Nausea and Vomiting in Patients With Advanced Cancer” NCT00124930
Known as NSC-170973 ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as NSC-615296 ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as R-1625 ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as Serenace ChEMBL registry synonym — accepted as the source's own label CHEMBL54
Known as TEVA-HALOPERIDOL “The oral investigational agent haloperidol (Generic Brand: TEVA-HALOPERIDOL) will be self-administered, at night, over 7 days.” NCT07109245
Action Inhibit “Typical antipsychotics, like haloperidol, are dopamine antagonists” NCT01161277
1

“Serotonin 2a (5-HT2a) receptor antagonist” CHEMBL54