drugset / Trial / NCT02098499
Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Haloperidol is known to be a safe alternative medication to control difficult pain, and has been shown effective when compared to placebo for controlling headaches. Investigators hypothesized that the combination of haloperidol and diphenhydramine would be a useful medication choice for migraine headache patients in the emergency department in comparison to a common migraine treatment regimen of metoclopramide and diphenhydramine.
Timeline
- Start
- 2013-06-12
- Primary completion
- 2015-02-11
- Completion
- 2015-02-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Haloperidol | Other / unclassified | 5 mg | Intravenous |
| Comparator | Metoclopramide | Small molecule | 10 mg | Intravenous |
| Comparator | Diphenhydramine | Unknown | 25 mg | Intravenous |