drugset / Trial / NCT02098499

Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT

NCT02098499 ↗

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Haloperidol is known to be a safe alternative medication to control difficult pain, and has been shown effective when compared to placebo for controlling headaches. Investigators hypothesized that the combination of haloperidol and diphenhydramine would be a useful medication choice for migraine headache patients in the emergency department in comparison to a common migraine treatment regimen of metoclopramide and diphenhydramine.

Timeline

Start
2013-06-12
Primary completion
2015-02-11
Completion
2015-02-11

Outcome

Outcome not reported

Stopped (Enrollment): “No recruitment occurred and PI retired”

Drugs

EvaluationDrugModalityDoseRoute
Comparator Haloperidol Other / unclassified 5 mg Intravenous
Comparator Metoclopramide Small molecule 10 mg Intravenous
Comparator Diphenhydramine Small molecule 25 mg Intravenous

Indications