Metoclopramide

also known as Maxolon · Reglan · Metoclopramide Nasal Spray · AHR-3070-C · Brand name of Metoclopramide is Reglan · Clopra · Clopra-"yellow" · Elieten · +29 more

Small molecule targets DRD2, HTR3A, HTR4 via inhibition / activation

Developed for: migraine disorder · gastroparesis · gastroesophageal reflux disease · headache disorder · myelodysplastic syndrome · traumatic encephalopathy · acute mountain sickness · aspiration pneumonia
+22 more
· chronic hiccup · dyskinesia of esophagus · gastroschisis · hyperemesis gravidarum · infectious disease with sepsis · intestinal obstruction · lung disorder · migraine with aura · migraine without aura · poisoning · pulmonary immaturity · stomach disorder · ulcer disease · cataract · drug-induced akathisia · food protein-induced enterocolitis syndrome · gastric dilatation · gastroenteritis · ileus · nutritional disorder · peripheral vertigo · traumatic brain injury
Investigated by: Montefiore Medical Center · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Evoke Pharma · Tanta University · University of Alberta · 940 Hospital of the People's Liberation Army Joint Logistic Support Force
+85 more
· Ache Laboratorios Farmaceuticos S.A. · Adiyaman University Research Hospital · Albert Einstein College of Medicine · Ankang Central Hospital · Arkansas Children's Hospital Research Institute · Australasian Leukaemia and Lymphoma Group · Autonomous University of Nuevo León · Azienda Ospedaliera San Gerardo di Monza · Barzilai Medical Center · Beersheva Mental Health Center · Canadian Institutes of Health Research (CIHR) · Children's Hospital Los Angeles · Children's Hospital of Michigan · Children's Hospital of Philadelphia · Children's National Research Institute · Duke University · First Affiliated Hospital Xi'an Jiaotong University · First People's Hospital of Xianyang · Franklyn Cladis · G. d'Annunzio University · General Hospital of Chinese Armed Police Forces · Harborview Injury Prevention and Research Center · Health Sciences North Research Institute · Hospital Universitario San Ignacio · IRCCS Burlo Garofolo · IVO JURISIC · Isfahan University of Medical Sciences · King Chulalongkorn Memorial Hospital · King Saud University · Kirby Institute · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London North West Healthcare NHS Trust · Mahidol University · Massachusetts General Hospital · Mater Misericordiae University Hospital · Merck Sharp & Dohme LLC · Mercy Health System · Michael Dean · Mount Sinai Hospital, Canada · Muhammad Aamir Latif · Nathalie Charpak · National Cancer Institute of Mexico · National Center for Research Resources (NCRR) · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Natural Sciences and Engineering Research Council, Canada · Pak Emirates Military Hospital · Pontificia Universidad Javeriana · Region Örebro County · Roswell Park Cancer Institute · Seattle Children's Hospital · Second Affiliated Hospital of Nanchang University · Shaheed Zulfiqar Ali Bhutto Medical University · Shahid Beheshti University of Medical Sciences · Simon Fisher · Siriraj Hospital · State University of New York at Buffalo · Swiss Cancer Institute · Tang-Du Hospital · The Hospital for Sick Children · The PLA General Hospital of Xinjiang · The Physicians' Services Incorporated Foundation · The Second Affiliated Hospital of Chongqing Medical University · The University of New South Wales · The University of Texas Health Science Center, Houston · Tirat Carmel Mental Health Center · Tongchuan Mining Hospital · Tongchuan People's Hospital · UCB Pharma · University Hospital, Bordeaux · University of Calgary · University of California, Los Angeles · University of Luebeck · University of Malaya · all 91 on the full record

Regulatory milestones approvals, filings & regulatory actions · 7 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansions (6)	US (FDA)	REGLAN	—	1981-01-22 – 1987-05-28	fda.gov ↗
Approved	US (FDA)	REGLAN	—	1979-02-07	fda.gov ↗

Trials 60 · a red edge is where a trial was stopped

today

US approved 1979

1978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/21 trial
Phase 1/2	NCT03056352	Mar → Jul 2017	—	Montefiore Medical Center	Completed	No outcome recorded
Phase 210 trials
Phase 2	NCT05342818	Apr → Jul 2022	gastroparesis	Tanta University	Completed	No outcome recorded
Phase 2	NCT03840057	Jul 2020 → Jun 2021	—	Waihong Chung	Unknown	No outcome recorded
Phase 2	NCT04027348	Jun 2019 → Sep 2021	intestinal obstruction	Roswell Park Cancer Institute	Terminated	No outcome recorded
Phase 2	NCT03970720	May 2019 → Jun 2027 expected	—	Simon Fisher	Recruiting	No outcome recorded
Phase 2	NCT03331965	Apr 2018 → Oct 2019	—	Duke University	Completed	No outcome recorded
Phase 2	NCT03383315	Jul → Sep 2017	poisoning	University of Malaya	Completed	No outcome recorded
Phase 2	NCT02163434	Jun 2014 → Oct 2019	hyperemesis gravidarum	State University of New York at Buffalo	Completed	No outcome recorded
Phase 2	NCT01791400	Jul 2009 → Nov 2010	migraine disorder	Isfahan University of Medical Sciences	Completed	No outcome recorded
Phase 2	NCT00120653	Jul 2005 → Jun 2008	myelodysplastic syndrome	National Heart, Lung, and Blood Institute (NHLBI)	Withdrawn	No outcome recorded
Phase 2	NCT00008736	—	—	National Center for Research Resources (NCRR)	Completed	No outcome recorded
Phase 2/31 trial
Phase 2/3	NCT03606369	Nov 2015 → Jul 2018	breast neoplasm	National Cancer Institute of Mexico	Unknown	No outcome recorded
Phase 316 trials
Phase 3	NCT06297954	Mar 2023 → Jun 2024	—	Autonomous University of Nuevo León	Completed	No outcome recorded
Phase 3	NCT05102591	Feb 2022 → Mar 2024	migraine disorder	University of Calgary	Completed	No outcome recorded
Phase 3	NCT05087615	Mar → Aug 2021	—	Shahid Beheshti University of Medical Sciences	Completed	No outcome recorded
Phase 3	NCT02582996	Apr 2020 → Apr 2021	migraine disorder	Ache Laboratorios Farmaceuticos S.A.	Suspended	No outcome recorded
Phase 3	NCT03220958	Aug 2017 → Apr 2020	traumatic encephalopathy	Montefiore Medical Center	Completed	No outcome recorded
Phase 3	NCT02466984	Jul 2016 → Feb 2018	—	University Hospital, Bordeaux	Completed	No outcome recorded
Phase 3	NCT02025751	Apr 2014 → Aug 2016	gastroparesis	Evoke Pharma	Completed	No outcome recorded
Phase 3	NCT02025725	Mar 2014 → May 2016	gastroparesis	Evoke Pharma	Completed	No outcome recorded
Phase 3	NCT02098915	Mar 2014 → Dec 2019	gastroschisis	The Hospital for Sick Children	Terminated	No outcome recorded
Phase 3	NCT02222220	Jan 2012 → May 2014	—	Beersheva Mental Health Center	Completed	No outcome recorded
Phase 3	NCT00557544	Jun → Dec 2009	migraine disorder	IRCCS Burlo Garofolo	Withdrawn	No outcome recorded
Phase 3	NCT00395161	Apr 2007 → Nov 2009	infectious disease with sepsis	Michael Dean	Terminated	No outcome recorded
Phase 3	NCT00275184	Jan 2006 → ?	myelodysplastic syndrome, small intestine disorder	London North West Healthcare NHS Trust	Unknown	No outcome recorded
Phase 3	NCT00147355	Nov 2005 → Nov 2008	HIV infectious disease	Kirby Institute	Terminated	No outcome recorded
Phase 3	NCT00131248	Apr 2004 → Mar 2008	gastroesophageal reflux disease	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 3	NCT00003213	May 1996 → Apr 1999	cancer of unknown primary site	Swiss Cancer Institute	Completed	No outcome recorded

Phase 417 trials
Phase 4	NCT07605065	Nov 2026 → Feb 2027 expected	headache disorder	Pak Emirates Military Hospital	Not yet recruiting	No outcome recorded
Phase 4	NCT07100691	Aug 2025 → May 2026 overdue	obesity disorder	Mater Misericordiae University Hospital	Not yet recruiting	No outcome recorded
Phase 4	NCT05746377	May 2023 → Feb 2024	stomach disorder, ulcer disease	Mercy Health System	Unknown	No outcome recorded
Phase 4	NCT05641051	Dec 2022 → Jun 2023	—	Tanta University	Completed	No outcome recorded
Phase 4	NCT05533281	Sep 2022 → Oct 2023	—	The Second Affiliated Hospital of Chongqing Medical University	Completed	No outcome recorded
Phase 4	NCT04873297	May → Oct 2021	aspiration pneumonia, stroke disorder	Shaheed Zulfiqar Ali Bhutto Medical University	Completed	No outcome recorded
Phase 4	NCT04771481	Apr 2021 → Sep 2022	—	King Chulalongkorn Memorial Hospital	Completed	No outcome recorded
Phase 4	NCT03778281	Dec 2018 → Dec 2019	chronic hiccup	Second Affiliated Hospital of Nanchang University	Unknown	No outcome recorded
Phase 4	NCT02907632	Apr 2017 → Jan 2019	gastroesophageal reflux disease	Nathalie Charpak	Completed	No outcome recorded
Phase 4	NCT02627950	Dec 2015 → Oct 2018	acute myocardial infarction	University of Luebeck	Completed	No outcome recorded
Phase 4	NCT02913469	Dec 2014 → Aug 2020	ST-elevation myocardial infarction	General Hospital of Chinese Armed Police Forces	Unknown	No outcome recorded
Phase 4	NCT01596166	Feb 2012 → Apr 2014	migraine with aura, migraine without aura	University of Alberta	Completed	No outcome recorded
Phase 4	NCT02703896	Jan 2012	lung disorder	King Saud University	Completed	No outcome recorded
Phase 4	NCT01191645	Oct → Nov 2010	dyskinesia of esophagus	Region Örebro County	Completed	No outcome recorded
Phase 4	NCT01781377	Feb 2008 → Jun 2013	pregnancy disorder	G. d'Annunzio University	Completed	No outcome recorded
Phase 4	NCT00364806	Aug 2006 → Mar 2007	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT00242450	Mar 2002 → Jul 2005	pulmonary immaturity	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Completed	No outcome recorded

Phase not applicable15 trials
—	NCT07084753	Jul → Sep 2025 overdue	obesity disorder	IVO JURISIC	Not yet recruiting	No outcome recorded
—	NCT06898268	Jul → Dec 2024	gastroesophageal reflux disease	Muhammad Aamir Latif	Completed	No outcome recorded
—	NCT05983354	Jan → Jun 2024	migraine disorder	Health Sciences North Research Institute	Unknown	No outcome recorded
—	NCT03560583	May 2021 → Dec 2027 expected	—	Barzilai Medical Center	Recruiting	No outcome recorded
—	NCT04252521	Jul 2019 → Jan 2020	migraine disorder	Adiyaman University Research Hospital	Completed	No outcome recorded
—	NCT02982668	Jan 2017 → Dec 2020	stroke disorder	Xijing Hospital	Terminated	No outcome recorded
—	NCT02965963	Dec 2016 → Jun 2025	—	University of Alberta	Completed	No outcome recorded
—	NCT02262923	Mar 2016 → Mar 2018	—	Mount Sinai Hospital, Canada	Withdrawn	No outcome recorded
—	NCT01522326	Mar 2012 → Mar 2017	acute mountain sickness	Massachusetts General Hospital	Completed	No outcome recorded
—	NCT01843868	Jan 2012 → Jun 2015	non-Hodgkin lymphoma	Australasian Leukaemia and Lymphoma Group	Withdrawn	No outcome recorded
—	NCT01631994	Sep 2011 → Mar 2015	—	Winthrop University Hospital	Terminated	No outcome recorded
—	NCT01067677	Feb 2010 → Feb 2012	—	Franklyn Cladis	Withdrawn	No outcome recorded
—	NCT01093690	Apr 2009 → Jun 2010	cancer	Mahidol University	Completed	No outcome recorded
—	NCT00139893	Jun → Oct 2005	gastroparesis	UCB Pharma	Completed	No outcome recorded
—	NCT00237705	May 2004 → ?	headache disorder, traumatic encephalopathy	Vancouver General Hospital	Unknown	No outcome recorded

Also used as a comparator or background therapy in 99 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT07343817 Background	Jul 2026 → Apr 2028 expected	—	Ahmed Nassar Ibrahim Mohammed	Not yet recruiting	No outcome recorded
Phase 0	NCT04290026 Comparator	Apr 2021 → Jan 2022	aspiration pneumonia	Assiut University	Unknown	No outcome recorded
Phase 17 trials
Phase 1	NCT07226362 Comparator	Jun → Oct 2025	—	Aspeya Switzerland SA	Completed	No outcome recorded
Phase 1	NCT06379217 Background	Jul 2024 → Aug 2026 overdue	prostate neuroendocrine neoplasm	Novartis Pharmaceuticals	Active not recruiting	No outcome recorded
Phase 1	NCT05222646 Comparator	Jan → Aug 2022	—	Uwakwe Emmanuel Chijioke	Unknown	No outcome recorded
Phase 1	NCT03801629 Background	Sep 2019 → Mar 2021	—	Yale University	Completed	No outcome recorded
Phase 1	NCT01243736 Comparator	Apr 2010 → Nov 2013	—	Mayo Clinic	Completed	No outcome recorded
Phase 1	NCT01289938 Comparator	Jul 2009 → Jun 2015	—	Matthias Schwab	Terminated	No outcome recorded
Phase 1	NCT00748059 Background	Dec 1996 → Dec 2020	autonomic nervous system disorder, disorder of catecholamine synthesis, orthostatic hypotension	Vanderbilt University Medical Center	Completed	No outcome recorded

Phase 1/22 trials
Phase 1/2	NCT05496179 Comparator	Aug 2022 → Jun 2023	food protein-induced enterocolitis syndrome	Ain Shams University	Completed	No outcome recorded
Phase 1/2	NCT01953081 Comparator	Jan → Sep 2014	food protein-induced enterocolitis syndrome	Takeda	Completed	No outcome recorded
Phase 29 trials
Phase 2	NCT05098067 Background	May → Oct 2022	hyperemesis gravidarum	Women and Infants Hospital of Rhode Island	Completed	No outcome recorded
Phase 2	NCT02441673 Comparator	Oct 2018 → Jan 2019	benign shuddering attacks	Lagos State Health Service Commission	Unknown	No outcome recorded
Phase 2	NCT03477903 Comparator	Aug 2018	—	Millennium Pharmaceuticals, Inc.	Terminated	No outcome recorded
Phase 2	NCT03268941 Comparator	Sep 2017 → Mar 2018	gastroparesis	Millennium Pharmaceuticals, Inc.	Completed	No outcome recorded
Phase 2	NCT02784392 Comparator	Oct 2016 → Mar 2018	—	Lyric Pharmaceuticals	Completed	No outcome recorded
Phase 2	NCT01934192 Comparator	Apr 2014 → Jul 2016	gastroparesis	GlaxoSmithKline	Terminated	No outcome recorded
Phase 2	NCT01148264 Comparator	Jul 2010 → Oct 2013	—	Karin Jordan	Terminated	No outcome recorded
Phase 2	NCT00845858 Comparator	Apr 2009 → Dec 2011	diabetes mellitus, gastroparesis	Evoke Pharma	Completed	No outcome recorded
Phase 2	NCT00355394 Comparator	Aug 2006 → Mar 2010	migraine disorder	Children's Hospital of Philadelphia	Completed	No outcome recorded

Phase 2/33 trials
Phase 2/3	NCT06390787 Comparator	Jan → Apr 2024	—	University of Baghdad	Completed	No outcome recorded
Phase 2/3	NCT01604785 Comparator	Nov 2012 → Aug 2016	migraine disorder	Oregon Health and Science University	Completed	No outcome recorded
Phase 2/3	NCT00632606 Comparator	Aug 2008 → Mar 2010	headache disorder	Women and Infants Hospital of Rhode Island	Withdrawn	No outcome recorded
Phase 316 trials
Phase 3	NCT07208305 Comparator	Feb 2026 → Dec 2027 expected	—	Affiliated Hospital of Qinghai University	Recruiting	No outcome recorded
Phase 3	NCT05876585 Comparator	Jun 2025 overdue	gastroenteritis	Genuine Research Center, Egypt	Not yet recruiting	No outcome recorded
Phase 3	NCT06793267 Comparator	Feb 2025 → Feb 2026 overdue	gastric dilatation	Assiut University	Not yet recruiting	No outcome recorded
Phase 3	NCT06826443 Comparator	Feb → May 2025 overdue	—	Ain Shams University	Not yet recruiting	No outcome recorded
Phase 3	NCT05586763 Comparator	Feb 2022 → Dec 2024	peripheral vertigo	Oman Medical Speciality Board	Unknown	No outcome recorded
Phase 3	NCT04726592 Background	Jul 2021 → Apr 2024	migraine with aura, migraine without aura	Assistance Publique - Hôpitaux de Paris	Terminated	No outcome recorded
Phase 3	NCT05967442 Comparator	Aug 2019 → Mar 2020	migraine disorder	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 3	NCT02979548 Background	Nov 2016 → Jun 2018	acute myeloid leukemia, chemotherapy-induced toxicity	Dr Atul Sharma	Unknown	No outcome recorded
Phase 3	NCT03081416 Comparator	May → Sep 2016	headache disorder	Brooke Army Medical Center	Completed	No outcome recorded
Phase 3	NCT02619201 Comparator	Nov 2015 → May 2016	gastroenteritis	Hospital General Naval de Alta Especialidad - Escuela Medico Naval	Unknown	No outcome recorded
Phase 3	NCT01984931 Comparator	Oct → Dec 2013	—	CM Chungmu Hospital	Unknown	No outcome recorded
Phase 3	NCT02135510 Comparator	Jun 2013 → Mar 2019	cancer	Amsterdam UMC, location VUmc	Completed	No outcome recorded
Phase 3	NCT00869310 Comparator	Sep 2009 → May 2012	—	S. Maria Hospital, Terni	Terminated	No outcome recorded
Phase 3	NCT01858090 Comparator	Jan → Oct 2009	—	Baskent University	Completed	No outcome recorded
Phase 3	NCT00682734 Comparator	Apr 2008 → Mar 2010	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 3	NCT00477776 Comparator	Apr 2006 → Sep 2008	—	National University Hospital, Singapore	Completed	No outcome recorded

Phase 440 trials
Phase 4	NCT06740812 Comparator	Dec 2026 → Sep 2027 expected	—	Montefiore Medical Center	Not yet recruiting	No outcome recorded
Phase 4	NCT07634393 Comparator	Aug 2026 → Jun 2028 expected	traumatic brain injury, traumatic encephalopathy	Montefiore Medical Center	Not yet recruiting	No outcome recorded
Phase 4	NCT07638527 Background	Jul 2026 → Feb 2027 expected	—	Faisalabad Medical University	Not yet recruiting	No outcome recorded
Phase 4	NCT07031479 Comparator	Jul 2025 → Jun 2026 overdue	—	Chulalongkorn University	Not yet recruiting	No outcome recorded
Phase 4	NCT06810531 Comparator	Feb → Jul 2025	—	Aiman Al-Touny	Completed	No outcome recorded
Phase 4	NCT06148025 Background	Nov 2023 → Oct 2027 expected	—	South Australian Health and Medical Research Institute	Recruiting	No outcome recorded
Phase 4	NCT05731960 Comparator	Mar 2023 → Apr 2025 overdue	—	IWK Health Centre	Recruiting	No outcome recorded
Phase 4	NCT04969120 Comparator	Mar → Jul 2022	—	Cairo University	Completed	No outcome recorded
Phase 4	NCT05033041 Comparator	Oct 2021 → Jan 2024	pregnancy disorder	Northwestern University	Completed	No outcome recorded
Phase 4	NCT04799015 Background	Jun 2021 → Nov 2024	traumatic encephalopathy	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT04766996 Background	May → Dec 2021	substance-related disorder	Emory University	Terminated	No outcome recorded
Phase 4	NCT04410536 Background	Jun 2020 → Dec 2021	migraine disorder	Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta	Completed	No outcome recorded
Phase 4	NCT04112823 Comparator	Dec 2019 → Dec 2022	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT03932578 Comparator	May → Aug 2019	—	Mansoura University	Completed	No outcome recorded
Phase 4	NCT05669781 Comparator	Oct 2018 → Sep 2019	ileus	Ikechukwu Bartholomew Ulasi	Completed	No outcome recorded
Phase 4	NCT03269435 Comparator	Nov 2017 → Mar 2020	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT03435003 Background	Aug 2017 → Mar 2019	—	Stony Brook University	Completed	No outcome recorded
Phase 4	NCT02009306 Background	Jan 2017 → Feb 2018	—	Gloucestershire Hospitals NHS Foundation Trust	Completed	No outcome recorded
Phase 4	NCT03017391 Comparator	Jan 2017 → Apr 2018	cancer	Radboud University Medical Center	Unknown	No outcome recorded
Phase 4	NCT02847494 Comparator	Sep 2016 → Sep 2017	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT02939235 Comparator	Jul 2016 → Dec 2017	intermediate coronary syndrome	Collegium Medicum w Bydgoszczy	Completed	No outcome recorded
Phase 4	NCT02459275 Background	Jul 2015 → Sep 2017	—	Clinical Evaluation Research Unit at Kingston General Hospital	Terminated	No outcome recorded
Phase 4	NCT02959840 Comparator	Jul 2015 → Mar 2016	—	Rutgers, The State University of New Jersey	Completed	No outcome recorded
Phase 4	NCT02441894 Background	Apr 2015 → Feb 2016	prostate cancer	Sanofi	Completed	No outcome recorded
Phase 4	NCT02314351 Comparator	Dec 2014 → Jan 2017	migraine disorder	Kocaeli University	Completed	No outcome recorded
Phase 4	NCT02972502 Comparator	Feb 2014 → Apr 2017	migraine disorder	OhioHealth	Terminated	No outcome recorded
Phase 4	NCT03017430 Background	Jan 2014 → Dec 2019	substance withdrawal syndrome	St. Petersburg Bekhterev Research Psychoneurological Institute	Completed	No outcome recorded
Phase 4	NCT01937234 Comparator	Jul 2013 → Jul 2016	—	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT02098499 Comparator	Jun 2013 → Feb 2015	migraine disorder	United States Naval Medical Center, Portsmouth	Withdrawn	No outcome recorded
Phase 4	NCT01825941 Comparator	Apr 2013 → Dec 2014	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT01636947 Background	Dec 2012 → Aug 2014	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 4	NCT01630109 Comparator	Dec 2012 → Jun 2013	—	Ascension Health	Completed	No outcome recorded
Phase 4	NCT02253524 Comparator	Nov 2012 → May 2013	—	Pamukkale University	Completed	No outcome recorded
Phase 4	NCT01837394 Comparator	Aug 2012 → Jun 2013	—	Jens Borglum Neimann	Completed	No outcome recorded
Phase 4	NCT01267864 Comparator	Nov 2010 → Mar 2013	migraine disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT01011673 Comparator	Nov 2009 → Sep 2012	headache disorder	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT01165866 Comparator	Jun → Dec 2008	gastroenteritis	Hamad Medical Corporation	Completed	No outcome recorded
Phase 4	NCT00475306 Comparator	May 2007 → Feb 2008	extrapyramidal and movement disease	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT00778011 Comparator	Nov 2005 → Dec 2006	—	WellSpan Health	Completed	No outcome recorded
Phase 4	NCT00910689 Comparator	Jul 2001 → Nov 2005	migraine disorder	Ohio University	Completed	No outcome recorded

Phase not applicable20 trials
—	NCT07086118 Comparator	May → Sep 2025 overdue	cataract	Alexandria University	Recruiting	No outcome recorded
—	NCT06343753 Comparator	May 2024 → May 2025	neuropathy, painful	Ain Shams University	Completed	No outcome recorded
—	NCT04682691 Comparator	Mar 2021 → Feb 2024	—	Cairo University	Completed	No outcome recorded
—	NCT04467528 Background	Apr 2020 → Mar 2021	—	China Medical University Hospital	Unknown	No outcome recorded
—	NCT04157998 Comparator	Nov 2019 → May 2020	aspiration pneumonia	Assiut University	Unknown	No outcome recorded
—	NCT03934294 Background	May 2019 → Mar 2021	hypopharyngeal carcinoma, oral cavity cancer	China Medical University Hospital	Completed	No outcome recorded
—	NCT03698292 Comparator	Oct 2018 → Jun 2019	—	Ain Shams University	Unknown	No outcome recorded
—	NCT04612998 Comparator	Feb 2017 → Mar 2018	hypotensive disorder, local anesthetic poisoning, obesity disorder, pregnancy disorder	Ataturk University	Completed	No outcome recorded
—	NCT02625181 Background	Jul 2016 → Nov 2017	—	Vanderbilt University	Completed	No outcome recorded
—	NCT02681211 Comparator	Feb 2016 → Nov 2024	migraine disorder	University of Louisville	Unknown	No outcome recorded
—	NCT02481219 Background	May 2015 → Jan 2016	colorectal cancer	Medtronic - MITG	Completed	No outcome recorded
—	NCT02288923 Comparator	Mar 2015 → Jul 2018	osteoarthritis, knee	Royal Devon and Exeter NHS Foundation Trust	Completed	No outcome recorded
—	NCT02410460 Background	Sep 2013 → Jun 2014	—	Mercy Facial Plastic Surgery Center	Completed	No outcome recorded
—	NCT02295280 Comparator	Jan 2012 → Nov 2014	headache disorder	St. Louis University	Completed	No outcome recorded
—	NCT01569633 Comparator	Oct 2011 → Feb 2014	nutritional disorder, pulmonary immaturity	East Tennessee State University	Withdrawn	No outcome recorded
—	NCT01406860 Comparator	Jul 2011 → Jul 2012	headache disorder	University of Iowa	Terminated	No outcome recorded
—	NCT01216410 Comparator	Dec 2008 → Apr 2011	—	Duke University	Completed	No outcome recorded
—	NCT00655642 Comparator	Mar 2007 → Oct 2008	—	Vanderbilt University	Terminated	No outcome recorded
—	NCT01069536 Comparator	Mar 2007	drug-induced akathisia	Pamukkale University	Completed	No outcome recorded
—	NCT00264719 Comparator	Jan 2006 → May 2008	—	National University Hospital, Singapore	Completed	No outcome recorded

Evidence & citations 45 cited values

Every value below carries the sentence it was read from. 163 sources stand behind the page.

Field	Value	Cited text
Known as	metoclopramide	“This study aimed to compare the therapeutic efficacy of metoclopramide, promethazine and prochloroperazine in patients presenting with signs and symptoms suggestive of acute...” NCT05586763 ↗ 156 “Early emesis: Ondansetron 16 mg IV + Dexamethasone 12 mg IV + Fosaprepitant 150 mg IV. and for delayed emesis: Metoclopramide 10 mg orally every 6 hours + Dexamethasone 8 mg...” NCT03606369 ↗ “STUDY DESIGN: We conducted a masked trial comparing metoclopramide, 0.2 mg/kg/dose q 6 hours, and ranitidine, 2 mg/kg/dose q 8 hours, with saline placebo.” PMID 19540518 ↗ Jun 2009 “METHODS: This phase 2a pilot study evaluated gastric emptying using the gastric emptying breath test, with metoclopramide as an internal control.” PMID 34148244 ↗ Jun 2021 “Anti-emetics (metoclopramide, prochlorperazine and lorazepam) may be prescribed to be used 'as needed' for breakthrough emesis.” NCT01843868 ↗ “Nonsteroidal anti-inflammatory (NSAID; ibuprofen) and anti-emetic (metoclopramide) medication could be added as needed.” NCT00910689 ↗ “Pre-operatively, all patients will receive Ondansetron 4 mg IV, and metoclopramide 10 mg intravenously (IV).” NCT06343753 ↗ “Prophylactic Metoclopramide 10 mg given before spinal together with prophylactic phenylephrine infusion” NCT01216410 ↗ “All participants receive intravenous infusion of metoclopramide(10mg) every 12 hours in the trial” NCT04467528 ↗ “Antacid premedication is permitted using ranitidine, metoclopramide or proton pump inhibitors.” NCT02288923 ↗ “drinking a teaspoon of metoclopramide 20 minutes prior to the capsule endoscopy test.” NCT01243736 ↗ “As a gastric motility-promoting drug, metoclopramide can accelerate gastric emptying.” NCT07343817 ↗ “Metoclopramide (10mg; oral) will be administered PRN to reduce nausea.” NCT03801629 ↗ “This group of infants will receive Metoclopramide at 0.1mg/kg q8 hrs.” NCT01569633 ↗ “new Orally Disintegrating Tablet of Reglan (metoclopramide)” NCT00139893 ↗ “Dexamethasone 4mg + metoclopramide 10mg, intravenously” NCT04112823 ↗ “Group EM (esomeprazole 20 mg+metoclopramide 10 mg)” NCT02703896 ↗ “Ketorolac, Diphenhydramine and Metoclopramide” NCT01604785 ↗ “metoclopramide i.m. injection” NCT04410536 ↗ “* Cyclizine * Metoclopramide” NCT02009306 ↗ “metoclopramide” NCT01243736 ↗ “Metoclopramide” NCT01067677 ↗ NCT02098499 ↗ NCT04682691 ↗ NCT00003213 ↗ NCT01406860 ↗ NCT07634393 ↗ NCT07638527 ↗ NCT05731960 ↗ NCT06390787 ↗ NCT00748059 ↗ NCT07100691 ↗ NCT06826443 ↗ NCT05098067 ↗ NCT02982668 ↗ NCT00778011 ↗ NCT06793267 ↗ NCT00237705 ↗ NCT05087615 ↗ NCT00475306 ↗ NCT07208305 ↗ NCT03560583 ↗ NCT02627950 ↗ NCT03932578 ↗ NCT00264719 ↗ NCT02222220 ↗ NCT02481219 ↗ NCT02979548 ↗ NCT00632606 ↗ NCT03017430 ↗ NCT02441673 ↗ NCT01825941 ↗ NCT07031479 ↗ NCT02262923 ↗ NCT01937234 ↗ NCT00355394 ↗ NCT07086118 ↗ NCT00242450 ↗ NCT01837394 ↗ NCT05983354 ↗ NCT03081416 ↗ NCT01093690 ↗ NCT05669781 ↗ NCT04027348 ↗ NCT05342818 ↗ NCT02314351 ↗ NCT01630109 ↗ NCT03477903 ↗ NCT02466984 ↗ NCT03840057 ↗ NCT06898268 ↗ NCT01148264 ↗ NCT02619201 ↗ NCT05102591 ↗ NCT03220958 ↗ NCT02295280 ↗ NCT00845858 ↗ NCT03383315 ↗ NCT02025725 ↗ NCT02098915 ↗ NCT05876585 ↗ NCT01267864 ↗ NCT00655642 ↗ NCT03269435 ↗ NCT04290026 ↗ NCT01791400 ↗ NCT02025751 ↗ NCT00120653 ↗ NCT01191645 ↗ NCT02441894 ↗ NCT02784392 ↗ NCT02582996 ↗ NCT01011673 ↗ NCT02135510 ↗ NCT03970720 ↗ NCT02410460 ↗ NCT04726592 ↗ NCT03331965 ↗ NCT01522326 ↗ NCT05222646 ↗ NCT00395161 ↗ NCT04799015 ↗ NCT06148025 ↗ NCT03056352 ↗ NCT04252521 ↗ NCT02847494 ↗ NCT05967442 ↗ NCT01636947 ↗ NCT02459275 ↗ NCT03017391 ↗ NCT07226362 ↗ NCT00275184 ↗ NCT02913469 ↗ NCT01069536 ↗ NCT02253524 ↗ NCT02163434 ↗ NCT03934294 ↗ NCT02625181 ↗ NCT00557544 ↗ NCT02959840 ↗ NCT00682734 ↗ NCT02681211 ↗ NCT00364806 ↗ NCT04157998 ↗ NCT04969120 ↗ NCT06810531 ↗ NCT00869310 ↗ NCT02939235 ↗ NCT05033041 ↗ NCT05496179 ↗ NCT01858090 ↗ NCT01596166 ↗ NCT06379217 ↗ NCT04771481 ↗ NCT05533281 ↗ NCT06740812 ↗ NCT01953081 ↗ NCT02972502 ↗ NCT04873297 ↗ NCT04612998 ↗ NCT07084753 ↗ NCT02965963 ↗ NCT05746377 ↗ NCT01165866 ↗ NCT01781377 ↗ NCT03698292 ↗ NCT06297954 ↗ NCT01934192 ↗ NCT00477776 ↗ NCT05641051 ↗ NCT07605065 ↗ NCT01984931 ↗ NCT02907632 ↗ NCT01289938 ↗ NCT00147355 ↗ NCT01631994 ↗ NCT00008736 ↗
Known as	AHR-3070-C	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Brand name of Metoclopramide is Reglan	“Brand name of Metoclopramide is Reglan” NCT01630109 ↗
Known as	Clopra	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Clopra-"yellow"	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Elieten	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Gastrese l.a.	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Gastrobid continus	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Gastroflux	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Gastromax	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Gimoti	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Maxolon	“Metoclopramide(Maxolon) promotes lactation by antagonizing the release of dopamine in the central nervous system, thereby increasing prolactin levels, and thus inducing or...” NCT00264719 ↗ 3 “The effect of a single dose of metoclopramide (Maxolon) on the gastric emptying rate of a liquid test meal was measured” PMID 4689832 ↗ Feb 1973 “Metoclopramide (Maxolon)” NCT06148025 ↗ “Metoclopramide (Maxolon)” NCT00477776 ↗
Known as	Maxolon sr	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Methoxyclopramide	ClinicalTrials.gov intervention name — accepted as the source's own label NCT03778281 ↗
Known as	Metipamid	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclomex	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclopramida	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclopramide dihydrochloride monohydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclopramide hcl monohydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	METOCLOPRAMIDE HYDROCHLORIDE	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclopramide hydrochloride monohydrate	“Anti-emetic medication protocol of Chungmu Hospital includes MACPERAN (Metoclopramide hydrochloride monohydrate 8.46 mg/2ml/A)thru IV twice in a day” NCT01984931 ↗
Known as	Metoclopramide intensol	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclopramide monohydrochloride monohydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metoclopramide Nasal Spray	“Metoclopramide nasal spray (MNS) was developed as an alternative to oral metoclopramide.” PMID 37924856 ↗ Nov 2023 1 “Metoclopramide Nasal Spray 10 mg” NCT02025751 ↗
Known as	Metoclopramidi hydrochloridum	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metox	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metozolv odt	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Metpamid (metoclopramide)	“Metpamid (metoclopramide)” NCT04252521 ↗
Known as	Metramid	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	MNS	“Metoclopramide nasal spray (MNS) was developed as an alternative to oral metoclopramide.” PMID 37924856 ↗ Nov 2023
Known as	MTP	“It has been reported that the most commonly used medications for parenteral treatment of vertigo and nausea-vomiting in emergency department are dimenhydrinate (DMT) and...” NCT02253524 ↗
Known as	Mygdalon	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	NSC-757117	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Parmid	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Primperan	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Reglan	“intravenous metoclopramide (Reglan) and intravenous prochlorperazine (Compazine)” NCT05967442 ↗ 3 “new Orally Disintegrating Tablet of Reglan (metoclopramide)” NCT00139893 ↗ NCT04766996 ↗ NCT03435003 ↗
Known as	Reglan odt	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Known as	Terperan	ChEMBL registry synonym — accepted as the source's own label CHEMBL86 ↗
Action	Activate	“Serotonin 4 (5-HT4) receptor agonist” CHEMBL86 ↗
Action	Inhibit	“Anti-dopaminergic medications such as metoclopramide are often considered first line medications” NCT00355394 ↗ 2 “Serotonin 3a (5-HT3a) receptor antagonist” CHEMBL86 ↗ “Dopamine D2 receptor antagonist” CHEMBL86 ↗
Modality	Small molecule	— CHEMBL86 ↗
Route	Oral	“metoclopramide 20 mg p.o. tds” PMID 12562658 ↗ Feb 2003
Target	DRD2	“Dopamine D2 receptor antagonist” CHEMBL86 ↗
Target	HTR3A	“Serotonin 3a (5-HT3a) receptor antagonist” CHEMBL86 ↗
Target	HTR4	“Serotonin 4 (5-HT4) receptor agonist” CHEMBL86 ↗