Prevention of Intraoperative Nausea and Vomiting During Cesarean Section

Completed 306 enrolled Duke University IWK Health Centre · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The study investigates the incidence of intraoperative nausea and vomiting under spinal anesthesia using a phenylephrine infusion with and without prophylactic antiemetics.

Timeline

Start: 2008-12
Primary completion: 2011-04
Completion: 2011-04

Outcome

Met primary endpoint

paper Intraoperative nausea and vomiting occurred in 49%, 31%, and 23% of patients in the placebo, metoclopramide, and combination groups, respectively (P<.001). PMID 23635626 ↗

Publications

Habib AS, George RB, McKeen DM, White WD, Ituk US, Megalla SA, Allen TK. Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial. Obstet Gynecol. 2013 Mar;121(3):615-623. doi: 10.1097/AOG.0b013e3182839fee.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Metoclopramide	Small molecule	10 mg	—
Subject	Ondansetron	Other / unclassified	4 mg	—
Comparator	Phenylephrine	Small molecule	—	—

Indications

No indication recorded.