drugset / Trial / NCT00910689
Drug and Non-Drug Treatment Of Severe Migraine
Phase 4
Completed
232 enrolled
Ohio University
GlaxoSmithKline · collabMerck Sharp & Dohme LLC · collabNational Institute of Neurological Disorders and Stroke (NINDS) · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to determine if the addition of preventive medication, behavior migraine management or the combination of preventive medication and behavior migraine management improves the outcome of optimal acute therapy for frequent migraines.
Timeline
- Start
- 2001-07
- Primary completion
- 2005-11
- Completion
- 2005-11
Publications
- Background Martin BC, Pathak DS, Sharfman MI, Adelman JU, Taylor F, Kwong WJ, Jhingran P. Validity and reliability of the migraine-specific quality of life questionnaire (MSQ Version 2.1). Headache. 2000 Mar;40(3):204-15. doi: 10.1046/j.1526-4610.2000.00030.x.
- Holroyd KA, Cottrell CK, O'Donnell FJ, Cordingley GE, Drew JB, Carlson BW, Himawan L. Effect of preventive (beta blocker) treatment, behavioural migraine management, or their combination on outcomes of optimised acute treatment in frequent migraine: randomised controlled trial. BMJ. 2010 Sep 29;341:c4871. doi: 10.1136/bmj.c4871.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Nadolol | Unknown | 80 mg | Oral |
| Comparator | Propranolol | Small molecule | 180 mg | Oral |
| Comparator | Ibuprofen | Small molecule | — | — |
| Comparator | Metoclopramide | Small molecule | — | — |
| Comparator | Sumatriptan | Unknown | — | Oral |
| Comparator | rizatriptan | Unknown | — | Oral |