drugset / Trial / NCT05342818

Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron

NCT05342818

Phase 2 Completed 90 enrolled Tanta University
RandomizedParallel-groupTriple-blindPrevention

Summary

One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention, vomiting, increased aspiration risk and consequently increased the length of hospital stay. In this study, investigators will evaluate Neostigmine's effect in reducing GRV in mechanically ventilated patients and compare its effect with metoclopramide and Ondansetron .

Timeline

Start
2022-04-15
Primary completion
2022-07-30
Completion
2022-10-17

Drugs

EvaluationDrugModalityDoseRoute
Subject Metoclopramide Small molecule 10 mg
Subject Neostigmine Other / unclassified 2.5 mg Intravenous
Subject Ondansetron Other / unclassified 8 mg Intravenous

Indications