Neostigmine

also known as NEO · neostigmine methylsulfate · Miostin · Neostigmine Methylsulphate · Stigmosan

Developed for: spinal cord injury · neurogenic bowel · constipation disorder · curariform drugs toxicity · headache disorder · ileus · pregnancy disorder · acute pancreatitis
+23 more
· autoinflammatory syndrome · colonic pseudo-obstruction · digestive system disorder · gastroparesis · infectious disease with sepsis · intracranial hypotension · myopathy · neuromuscular disease · obstructive jaundice · osteoarthritis, knee · palsy · respiratory paralysis · delirium · intestinal disorder · intestinal dysmotility syndrome · lung disorder · neuropathy, painful · obstructive sleep apnea syndrome · ocular hypotension · pulmonary immaturity · respiratory system disorder · urinary bladder disorder · urinary tract obstruction
Investigated by: James J. Peters Veterans Affairs Medical Center · Merck Sharp & Dohme LLC · University Hospital Olomouc · Assiut University · Cairo University · Palacky University
+41 more
· Pontifical Catholic University of São Paulo · Seoul National University Hospital · Tampere University Hospital · US Department of Veterans Affairs · University of Washington · Ain Shams University · Alexandria University · Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Gadjah Mada · Baqiyatallah Medical Sciences University · Beijing Tongren Hospital · Brno University Hospital · Chang Gung Memorial Hospital · Clayton Petro · Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Congressionally Directed Medical Research Programs · Emory University · Endeavor Health · IGA - internal grant agency, Ministry of Health · Indonesia University · Leiden University Medical Center · M.D. Anderson Cancer Center · Mansoura University · Masaryk Hospital Usti nad Labem · Mayo Clinic · Memorial Sloan Kettering Cancer Center · National Institutes of Health Clinical Center (CC) · Onze Lieve Vrouw Hospital · Reham Ali Abdelhaleem Abdelrahman · SMG-SNU Boramae Medical Center · Southeast University, China · St. Anne's University Hospital Brno, Czech Republic · Tanta University · Technical University of Munich · The First Affiliated Hospital of Nanchang University · University Hospital, Linkoeping · University of South Florida · University of Southern California · University of Surabaya · Wake Forest University · Wanqing Gu · Yonsei University

Trials 54 · a red edge is where a trial was stopped

1996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 04 trials
Phase 0	NCT06351852	Mar 2022 → Sep 2024	constipation disorder, neurogenic bowel, spinal cord injury	James J. Peters Veterans Affairs Medical Center	Completed	No outcome recorded
Phase 0	NCT04027972	Mar 2020 → Dec 2022	constipation disorder, neurogenic bowel, spinal cord injury	James J. Peters Veterans Affairs Medical Center	Completed	No outcome recorded
Phase 0	NCT03316963	Nov 2017 → Mar 2019	—	Emory University	Terminated	No outcome recorded
Phase 0	NCT02370862	Feb 2013 → Dec 2016	neurogenic bowel, spinal cord injury	James J. Peters Veterans Affairs Medical Center	Completed	No outcome recorded
Phase 13 trials
Phase 1	NCT04671030	Jan → Jun 2018	constipation disorder, neurogenic bowel, spinal cord injury	James J. Peters Veterans Affairs Medical Center	Completed	No outcome recorded
Phase 1	NCT02370433	Dec 2012 → Jun 2018	neurogenic bowel, spinal cord injury	James J. Peters Veterans Affairs Medical Center	Unknown	No outcome recorded
Phase 1	NCT00779467	Oct 2008 → Nov 2013	—	Wake Forest University	Completed	No outcome recorded
Phase 1/22 trials
Phase 1/2	NCT03058263	Oct 2016 → Feb 2017	—	Indonesia University	Completed	No outcome recorded
Phase 1/2	NCT02279147	Aug 2014 → Aug 2017	autoinflammatory syndrome, obstructive jaundice	Wanqing Gu	Unknown	No outcome recorded
Phase 25 trials
Phase 2	NCT05342818	Apr → Jul 2022	gastroparesis	Tanta University	Completed	No outcome recorded
Phase 2	NCT05116930	Nov 2021 → Dec 2027 expected	intracranial hypotension	Mayo Clinic	Recruiting	No outcome recorded
Phase 2	NCT04130230	Mar 2019 → Aug 2021	infectious disease with sepsis	Mansoura University	Completed	No outcome recorded
Phase 2	NCT02543658	Sep 2015 → Aug 2017	acute pancreatitis	The First Affiliated Hospital of Nanchang University	Completed	No outcome recorded
Phase 2	NCT00855283	Sep 2012 → Jun 2013	—	US Department of Veterans Affairs	Completed	No outcome recorded
Phase 2/31 trial
Phase 2/3	NCT04905953	Feb 2021 → Feb 2022	headache disorder	Cairo University	Unknown	No outcome recorded
Phase 37 trials
Phase 3	NCT06871033	Jan → Dec 2024	—	Alexandria University	Completed	No outcome recorded
Phase 3	NCT04910477	Jun → Sep 2021	headache disorder	Assiut University	Completed	No outcome recorded
Phase 3	NCT06351995	Nov 2020 → Oct 2022 overdue	constipation disorder, neurogenic bowel, spinal cord injury	James J. Peters Veterans Affairs Medical Center	Active not recruiting	No outcome recorded
Phase 3	NCT04096144	Oct 2019 → Mar 2020 overdue	—	University of South Florida	Not yet recruiting	No outcome recorded
Phase 3	NCT03116997	Apr 2017 → Mar 2022	—	Memorial Sloan Kettering Cancer Center	Completed	No outcome recorded
Phase 3	NCT01422304	Oct 2011 → Sep 2012	blood coagulation disease, osteoarthritis, hip, osteoarthritis, knee	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT00724932	Jul 2008 → Apr 2009	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 419 trials
Phase 4	NCT06685705	Dec 2024 → Dec 2025 overdue	—	Assiut University	Not yet recruiting	No outcome recorded
Phase 4	NCT05985343	Jan 2024 → May 2025	abdominal wall malformation, ileus	Clayton Petro	Completed	No outcome recorded
Phase 4	NCT04951726	Feb 2022 → Aug 2025	colonic pseudo-obstruction	University of Southern California	Unknown	No outcome recorded
Phase 4	NCT05037006	Oct → Dec 2021	curariform drugs toxicity	Pontifical Catholic University of São Paulo	Unknown	No outcome recorded
Phase 4	NCT05053594	Oct 2021 → Feb 2022	curariform drugs toxicity	Pontifical Catholic University of São Paulo	Unknown	No outcome recorded
Phase 4	NCT03958201	May 2019 → Jan 2020	respiratory paralysis	University of Washington	Completed	No outcome recorded
Phase 4	NCT03543826	May → Nov 2018	myopathy	University of Washington	Completed	No outcome recorded
Phase 4	NCT03210376	Nov 2017 → Sep 2018	digestive system cancer, female reproductive organ cancer, male reproductive organ cancer, malignant urinary system neoplasm	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 4	NCT02845375	Sep 2016 → Sep 2018	respiratory failure	Leiden University Medical Center	Completed	No outcome recorded
Phase 4	NCT03420937	Jun 2016 → Jun 2017	—	University Hospital Olomouc	Completed	No outcome recorded
Phase 4	NCT02403063	Sep → Oct 2015	—	Onze Lieve Vrouw Hospital	Completed	No outcome recorded
Phase 4	NCT02513693	Jul 2015 → Mar 2016	—	Palacky University	Unknown	No outcome recorded
Phase 4	NCT02433808	Apr 2015 → Dec 2016	—	Endeavor Health	Completed	No outcome recorded
Phase 4	NCT01718236	Sep 2012 → Jan 2015	pregnancy disorder	Brno University Hospital	Completed	No outcome recorded
Phase 4	NCT01142648	Apr 2009 → Mar 2010	—	Tampere University Hospital	Completed	No outcome recorded
Phase 4	NCT00745095	Mar 2009 → Mar 2013	spinal cord injury	US Department of Veterans Affairs	Completed	No outcome recorded
Phase 4	NCT00895609	Mar → Aug 2009	neuromuscular disease	Technical University of Munich	Completed	No outcome recorded
Phase 4	NCT00676377	Aug → Dec 2007	ileus	Baqiyatallah Medical Sciences University	Completed	No outcome recorded
Phase 4	NCT00001520	Sep 1996 → Aug 2000	palsy	National Institutes of Health Clinical Center (CC)	Completed	No outcome recorded

Phase not applicable13 trials
—	NCT07692282	Jul 2026 → Feb 2028 expected	digestive system disorder	Southeast University, China	Not yet recruiting	No outcome recorded
—	NCT07524959	May → Jul 2026 overdue	—	Beijing Tongren Hospital	Not yet recruiting	No outcome recorded
—	NCT07253428	Oct → Dec 2025 overdue	nasal disorder	Ain Shams University	Active not recruiting	No outcome recorded
—	NCT06275542	Apr → Dec 2024 overdue	—	University of Surabaya	Enrolling by invitation	No outcome recorded
—	NCT05993390	Jan 2024 → Aug 2027 expected	—	Seoul National University Hospital	Recruiting	No outcome recorded
—	NCT04997759	Sep 2021 → Aug 2022	—	Chang Gung Memorial Hospital	Unknown	No outcome recorded
—	NCT04873531	May → Aug 2021	thyroid gland disorder	Seoul National University Hospital	Completed	No outcome recorded
—	NCT04544228	Sep 2020 → Feb 2021	—	Cairo University	Completed	No outcome recorded
—	NCT04048655	Apr 2020 → Sep 2025 overdue	—	Tampere University Hospital	Active not recruiting	No outcome recorded
—	NCT04777383	Apr 2019 → Oct 2021	vascular disorder	University Hospital, Linkoeping	Terminated	No outcome recorded
—	NCT06055101	Jan 2019 → Mar 2022	—	Reham Ali Abdelhaleem Abdelrahman	Completed	No outcome recorded
—	NCT01980069	Nov 2013 → Oct 2014	—	Yonsei University	Completed	No outcome recorded
—	NCT00407290	Mar → Oct 2006	pregnancy disorder	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	Unknown	No outcome recorded

Also used as a comparator or background therapy in 144 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT06501352 Comparator	Jan 2023 → Mar 2024	—	Ain Shams University	Completed	No outcome recorded
Phase 0	NCT03328312 Comparator	Dec 2017 → Mar 2018	curariform drugs toxicity	Iuliu Hatieganu University of Medicine and Pharmacy	Unknown	No outcome recorded
Phase 14 trials
Phase 1	NCT06787638 Comparator	Jan 2025 → Jan 2026 overdue	—	Aswan University Hospital	Not yet recruiting	No outcome recorded
Phase 1	NCT06982092 Comparator	Aug 2024 → Jan 2025	—	Ain Shams University	Completed	No outcome recorded
Phase 1	NCT03579589 Comparator	Aug 2018 → Dec 2019	—	Ohio State University	Completed	No outcome recorded
Phase 1	NCT02574611 Comparator	Oct 2015 → Dec 2017	digestive system disorder	James J. Peters Veterans Affairs Medical Center	Withdrawn	No outcome recorded
Phase 1/23 trials
Phase 1/2	NCT07097441 Comparator	Mar → Jun 2025	cardiac rhythm disease, hypertensive disorder, respiratory paralysis	Ziauddin University	Completed	No outcome recorded
Phase 1/2	NCT06729047 Comparator	Dec 2024 → Nov 2025 overdue	intracranial hypotension	Assiut University	Not yet recruiting	No outcome recorded
Phase 1/2	NCT06794450 Comparator	Nov 2024 → Feb 2025 overdue	curariform drugs toxicity	Padjadjaran University	Recruiting	No outcome recorded
Phase 28 trials
Phase 2	NCT05898919 Comparator	Mar 2022 → May 2023	urinary bladder disorder	Chengdu University of Traditional Chinese Medicine	Completed	No outcome recorded
Phase 2	NCT04347486 Comparator	Apr 2020 → Dec 2021	—	Seoul National University Hospital	Completed	No outcome recorded
Phase 2	NCT04244097 Comparator	Apr → Jul 2020	—	Kasr El Aini Hospital	Completed	No outcome recorded
Phase 2	NCT03904550 Comparator	Dec 2019 → Aug 2022	impaired renal function disease	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 2	NCT03943888 Comparator	Aug 2019 → Feb 2020	—	Seoul National University Hospital	Completed	No outcome recorded
Phase 2	NCT03519724 Comparator	Jul → Sep 2018	curariform drugs toxicity	Campus-Bio-Medico University	Unknown	No outcome recorded
Phase 2	NCT03519633 Comparator	Apr 2018 → Dec 2024	curariform drugs toxicity	Campus-Bio-Medico University	Completed	No outcome recorded
Phase 2	NCT02839668 Background	Aug 2016 → Sep 2019	breast cancer	Iuliu Hatieganu University of Medicine and Pharmacy	Completed	No outcome recorded

Phase 2/36 trials
Phase 2/3	NCT06513013 Comparator	Dec 2023 → Jan 2026	—	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT03212495 Comparator	Aug → Nov 2017	osteoarthritis, knee	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT03248648 Comparator	Mar → Sep 2017	—	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT03021772 Comparator	Jan 2017 → Sep 2018	—	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT02752308 Comparator	Sep 2014 → Mar 2015	hypospadias	Isfahan University of Medical Sciences	Completed	No outcome recorded
Phase 2/3	NCT01629394 Comparator	Jan → Oct 2012	morbid obesity	University of Patras	Unknown	No outcome recorded

Phase 315 trials
Phase 3	NCT07271875 Comparator	Jan 2026 → Nov 2027 expected	ileus, intestinal dysmotility syndrome	Xijing Hospital	Not yet recruiting	No outcome recorded
Phase 3	NCT06136585 Comparator	Jun 2024 → Oct 2026 expected	—	The Cleveland Clinic	Recruiting	No outcome recorded
Phase 3	NCT05802979 Comparator	Jan → Sep 2023	—	Ain Shams University	Unknown	No outcome recorded
Phase 3	NCT03513406 Comparator	Mar 2018 → Mar 2023	—	University of Kansas Medical Center	Completed	No outcome recorded
Phase 3	NCT02666014 Comparator	Jun 2015 → Dec 2017	—	KK Women's and Children's Hospital	Completed	No outcome recorded
Phase 3	NCT01962298 Comparator	Oct 2013 → Dec 2014	diaphragm disorder, myopathy	University Hospital, Antwerp	Completed	No outcome recorded
Phase 3	NCT01479764 Comparator	Dec 2011 → Oct 2012	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT01809886 Comparator	Oct 2011 → Oct 2013	—	Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia	Completed	No outcome recorded
Phase 3	NCT01050543 Comparator	Feb → Aug 2010	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT00825812 Comparator	Jan → Sep 2010	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT00847938 Comparator	Mar → Oct 2009	—	Centre Hospitalier Departemental Vendee	Completed	No outcome recorded
Phase 3	NCT00675792 Comparator	May → Sep 2008	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT00473694 Comparator	Nov 2005 → Nov 2006	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT00451217 Comparator	Nov 2005 → Mar 2006	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT00451100 Comparator	Nov 2005 → May 2006	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded

Phase 468 trials
Phase 4	NCT07666984 Comparator	Jun → Jul 2026 overdue	—	Cukurova University	Recruiting	No outcome recorded
Phase 4	NCT07203287 Comparator	Aug 2025 → Dec 2026 expected	—	The University of Texas Medical Branch, Galveston	Recruiting	No outcome recorded
Phase 4	NCT06493838 Comparator	Jul 2024 → Jan 2025 overdue	—	Minia University	Not yet recruiting	No outcome recorded
Phase 4	NCT06112353 Comparator	Apr 2024 → Jul 2026 overdue	intestinal disorder	University of California, Irvine	Recruiting	No outcome recorded
Phase 4	NCT06228092 Comparator	Dec 2023 → May 2025	curariform drugs toxicity	Matias Vested	Completed	No outcome recorded
Phase 4	NCT05545280 Comparator	Dec 2023 → Aug 2024	—	The Cleveland Clinic	Completed	No outcome recorded
Phase 4	NCT05794503 Comparator	Sep 2023 → Jun 2024	urinary tract obstruction	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 4	NCT05887375 Comparator	Aug 2023 → Jan 2026	urinary tract obstruction	University of Missouri-Columbia	Completed	No outcome recorded
Phase 4	NCT05256901 Comparator	Jul 2023 → Jul 2024	appendicitis	Emory University	Terminated	No outcome recorded
Phase 4	NCT05817019 Comparator	Apr 2023 → Dec 2024	COVID-19	Korea University Ansan Hospital	Unknown	No outcome recorded
Phase 4	NCT06081738 Comparator	Mar → Sep 2023	—	Menoufia University	Unknown	No outcome recorded
Phase 4	NCT05718934 Comparator	Nov 2022 → Dec 2023	—	Ciusss de L'Est de l'Île de Montréal	Completed	No outcome recorded
Phase 4	NCT05354466 Comparator	Jun 2022 → Sep 2024	respiratory system disorder	Seoul National University Hospital	Completed	No outcome recorded
Phase 4	NCT04920682 Comparator	Jun → Aug 2021	—	Pontifical Catholic University of São Paulo	Completed	No outcome recorded
Phase 4	NCT04606901 Comparator	Apr 2021 → Jul 2023	chronic obstructive pulmonary disease	Temple University	Completed	No outcome recorded
Phase 4	NCT04546672 Comparator	Mar 2021 → Jun 2023	bowel dysfunction	Oregon Health and Science University	Completed	No outcome recorded
Phase 4	NCT03923556 Comparator	Feb 2021 → Sep 2023	curariform drugs toxicity	University of Colorado, Denver	Completed	No outcome recorded
Phase 4	NCT04720287 Comparator	Feb → Apr 2021	—	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT04570150 Comparator	Jan 2021 → Jan 2023	—	University of California, San Diego	Completed	No outcome recorded
Phase 4	NCT04364607 Comparator	Aug 2020 → Oct 2021	—	Mansoura University	Completed	No outcome recorded
Phase 4	NCT04332627 Comparator	Feb → May 2020	gallbladder disorder	Seoul National University Bundang Hospital	Completed	No outcome recorded
Phase 4	NCT03909165 Comparator	Jul 2019 → Sep 2023	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 4	NCT03944473 Comparator	Jun 2019 → Jul 2020	gait apraxia	Montefiore Medical Center	Withdrawn	No outcome recorded
Phase 4	NCT03996655 Comparator	Jun → Sep 2019	curariform drugs toxicity	National Cancer Institute, Egypt	Unknown	No outcome recorded
Phase 4	NCT03939923 Comparator	May 2019 → Jul 2021	coronary artery disorder	West Virginia University	Completed	No outcome recorded
Phase 4	NCT04365686 Background	Apr 2019 → Apr 2020	—	Fayoum University Hospital	Completed	No outcome recorded
Phase 4	NCT03679611 Comparator	Jan 2019 → Oct 2021	obstructive sleep apnea syndrome	University Health Network, Toronto	Completed	No outcome recorded
Phase 4	NCT02825576 Comparator	Dec 2018 → Apr 2020	—	Northern Sydney Anaesthesia Research Institute	Terminated	No outcome recorded
Phase 4	NCT03505255 Comparator	Sep 2018 → Sep 2020	—	Assiut University	Unknown	No outcome recorded
Phase 4	NCT03574337 Comparator	Aug 2018	curariform drugs toxicity	Henry Ford Health System	Withdrawn	No outcome recorded
Phase 4	NCT03351608 Comparator	Feb 2018 → Jan 2020	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 4	NCT03276026 Comparator	Feb → Nov 2018	respiratory system disorder	Virtua Health, Inc.	Terminated	No outcome recorded
Phase 4	NCT03346070 Comparator	Jan 2018 → Jan 2019	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 4	NCT03346057 Comparator	Dec 2017 → Sep 2019	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 4	NCT03322657 Comparator	Nov 2017 → Dec 2020	—	The Cleveland Clinic	Completed	No outcome recorded
Phase 4	NCT03168308 Comparator	Sep 2017 → Sep 2019	—	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 4	NCT03138967 Comparator	Sep 2017 → Sep 2018	urinary bladder cancer	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 4	NCT03034577 Comparator	Jun 2017 → Feb 2019	—	University of Melbourne	Completed	No outcome recorded
Phase 4	NCT03112993 Comparator	May 2017 → Aug 2018	—	University of Missouri-Columbia	Completed	No outcome recorded
Phase 4	NCT03111121 Comparator	May 2017 → Jun 2018	—	West Virginia University	Completed	No outcome recorded
Phase 4	NCT03144453 Comparator	May 2017 → Dec 2019	—	Regina Elena Cancer Institute	Unknown	No outcome recorded
Phase 4	NCT03229486 Comparator	Mar 2017 → Jul 2019	delirium	Pusan National University Yangsan Hospital	Completed	No outcome recorded
Phase 4	NCT02861131 Comparator	Jan 2017 → Apr 2018	—	Oregon Health and Science University	Completed	No outcome recorded
Phase 4	NCT02909439 Comparator	Nov 2016 → Nov 2017	—	Stony Brook University	Completed	No outcome recorded
Phase 4	NCT02860507 Comparator	Aug 2016 → Feb 2018	—	University of South Florida	Completed	No outcome recorded
Phase 4	NCT02648503 Comparator	Mar → Sep 2016	neuromuscular disease	University of Medicine and Pharmacy at Ho Chi Minh City	Unknown	No outcome recorded
Phase 4	NCT02410590 Comparator	Jul 2015 → Oct 2016	—	Merck Sharp & Dohme LLC	Withdrawn	No outcome recorded
Phase 4	NCT02455921 Comparator	Jun 2015 → Mar 2018	—	Attikon Hospital	Completed	No outcome recorded
Phase 4	NCT02390817 Comparator	Mar 2015 → Aug 2017	scoliosis	Cukurova University	Completed	No outcome recorded
Phase 4	NCT02329964 Comparator	Feb → Aug 2015	—	Korea University Anam Hospital	Unknown	No outcome recorded
Phase 4	NCT02361060 Comparator	Feb 2015 → Jul 2016	—	Enrique Alday Muñoz	Completed	No outcome recorded
Phase 4	NCT02256280 Comparator	Jan 2015 → Mar 2020	—	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano	Terminated	No outcome recorded
Phase 4	NCT02327923 Comparator	Jan 2015 → Feb 2016	gallstones	B.P. Koirala Institute of Health Sciences	Completed	No outcome recorded
Phase 4	NCT02284412 Comparator	Dec 2014	—	Onze Lieve Vrouw Hospital	Completed	No outcome recorded
Phase 4	NCT02414880 Comparator	Dec 2014 → Aug 2015	cirrhosis of liver	Cairo University	Completed	No outcome recorded
Phase 4	NCT02698969 Comparator	Nov 2014 → Feb 2017	curariform drugs toxicity	University of Florence	Unknown	No outcome recorded
Phase 4	NCT02375217 Comparator	Oct 2014 → Oct 2015	—	American University of Beirut Medical Center	Completed	No outcome recorded
Phase 4	NCT02243943 Comparator	Sep 2014 → Apr 2016	lung disorder	Leiden University Medical Center	Completed	No outcome recorded
Phase 4	NCT02215382 Comparator	Aug → Oct 2014	ocular hypotension	Ordu University	Completed	No outcome recorded
Phase 4	NCT02286752 Comparator	Jun 2014 → Jan 2015	—	Ordu University	Completed	No outcome recorded
Phase 4	NCT01761552 Comparator	Aug 2013 → Dec 2015	—	Hadassah Medical Organization	Unknown	No outcome recorded
Phase 4	NCT05066035 Comparator	May 2013 → Oct 2016	curariform drugs toxicity	Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital	Completed	No outcome recorded
Phase 4	NCT01748643 Comparator	Apr 2013 → Jan 2015	obesity disorder	Ziekenhuis Oost-Limburg	Completed	No outcome recorded
Phase 4	NCT01539044 Comparator	Feb 2012 → Jun 2013	curariform drugs toxicity	Hospital Sultanah Aminah Johor Bahru	Completed	No outcome recorded
Phase 4	NCT02160223 Comparator	Jan 2012 → Jun 2014	obstructive sleep apnea syndrome	Diskapi Teaching and Research Hospital	Completed	No outcome recorded
Phase 4	NCT01453530 Comparator	Oct 2011 → Sep 2012	—	Radboud University Medical Center	Unknown	No outcome recorded
Phase 4	NCT01199237 Comparator	Aug 2010 → Aug 2012	—	University of California, San Francisco	Completed	No outcome recorded
Phase 4	NCT01134848 Comparator	Jan 2009 → Feb 2010	biliary dyskinesia	University of Nottingham	Completed	No outcome recorded

Phase not applicable38 trials
—	NCT05785377 Comparator	Dec 2027 → Jul 2029 expected	—	Mansoura University	Not yet recruiting	No outcome recorded
—	NCT07309393 Comparator	Dec 2025 → Sep 2026 expected	—	Shanghai Pulmonary Hospital, Shanghai, China	Recruiting	No outcome recorded
—	NCT06678451 Comparator	Dec 2024 → May 2025 overdue	—	Shanxi Bethune Hospital	Not yet recruiting	No outcome recorded
—	NCT06436768 Comparator	Jun 2024 → Mar 2025	—	Beijing Tongren Hospital	Completed	No outcome recorded
—	NCT06334562 Comparator	Jun 2024 → Dec 2025 overdue	—	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	Recruiting	No outcome recorded
—	NCT06398899 Comparator	May 2024 → Jun 2025	chronic otitis media, chronic rhinosinusitis, laryngeal disorder	National Taiwan University Hospital	Completed	No outcome recorded
—	NCT05344417 Background	Mar 2024 → Dec 2026 expected	ileus	Ohio State University	Recruiting	No outcome recorded
—	NCT05825430 Background	Apr → Jun 2023	—	Al-Azhar University	Completed	No outcome recorded
—	NCT05724550 Comparator	Feb 2023 → Jun 2024	curariform drugs toxicity	Seoul National University Hospital	Completed	No outcome recorded
—	NCT06210165 Comparator	Dec 2022 → Jun 2024	pulmonary immaturity	Rhendra Hardy Mohamad Zaini	Unknown	No outcome recorded
—	NCT04565301 Comparator	Jun 2021 → Jul 2022	neuropathy, painful	Cairo University	Completed	No outcome recorded
—	NCT04492319 Comparator	Sep 2020 → Nov 2023	—	Cairo University	Completed	No outcome recorded
—	NCT04545099 Comparator	Sep 2020 → Sep 2022	—	Yonsei University	Unknown	No outcome recorded
—	NCT04566796 Comparator	Aug 2020 → Feb 2021	—	Alexandria University	Unknown	No outcome recorded
—	NCT04258007 Comparator	Jan → Nov 2020	—	Mansoura University	Completed	No outcome recorded
—	NCT04205097 Comparator	Dec 2019 → Dec 2020	gastric cancer	Ajou University School of Medicine	Completed	No outcome recorded
—	NCT04161508 Comparator	Dec 2019 → Dec 2021	—	Taipei Veterans General Hospital, Taiwan	Unknown	No outcome recorded
—	NCT04407078 Comparator	Dec 2019 → Jan 2021	gallbladder disorder	Ajou University School of Medicine	Completed	No outcome recorded
—	NCT04022733 Background	Oct 2019 → Aug 2021	abdominal wall malformation	Ajou University School of Medicine	Completed	No outcome recorded
—	NCT03791801 Comparator	Sep 2019 → Dec 2020	—	McGill University Health Centre/Research Institute of the McGill University Health Centre	Unknown	No outcome recorded
—	NCT04720573 Comparator	Jun → Oct 2019	—	Başakşehir Çam & Sakura City Hospital	Completed	No outcome recorded
—	NCT03583021 Comparator	Jun → Oct 2018	gallbladder disorder	Ajou University School of Medicine	Completed	No outcome recorded
—	NCT03292965 Comparator	Sep → Nov 2017	curariform drugs toxicity	Seoul National University Bundang Hospital	Completed	No outcome recorded
—	NCT03108989 Comparator	Feb → Jul 2017	—	Yonsei University	Completed	No outcome recorded
—	NCT03019835 Comparator	Dec 2016 → Apr 2017	curariform drugs toxicity	Université Libre de Bruxelles	Completed	No outcome recorded
—	NCT02939430 Comparator	Nov 2016 → Oct 2017	—	Mansoura University	Unknown	No outcome recorded
—	NCT02944175 Comparator	Jul 2016 → Sep 2019	supratentorial cancer	Mansoura University	Unknown	No outcome recorded
—	NCT02546843 Comparator	Dec 2015 → Sep 2018	—	Brno University Hospital	Completed	No outcome recorded
—	NCT07033442 Comparator	Jul → Nov 2015	ocular hypertension	Ataturk Training and Research Hospital	Completed	No outcome recorded
—	NCT02454504 Comparator	Mar 2015 → Aug 2016	—	Regina Elena Cancer Institute	Completed	No outcome recorded
—	NCT03137290 Comparator	Dec 2014 → Jun 2016	—	Universiti Sains Malaysia	Completed	No outcome recorded
—	NCT02213848 Background	Aug → Oct 2014	curariform drugs toxicity	Seoul National University Hospital	Completed	No outcome recorded
—	NCT02109133 Comparator	May → Dec 2014	—	Yonsei University	Completed	No outcome recorded
—	NCT02037516 Comparator	Jan 2014 → Feb 2016	morbid obesity, respiratory system disorder	Coastal Anesthesiology Consultants	Completed	No outcome recorded
—	NCT02697929 Comparator	Jan 2014 → Jan 2019	curariform drugs toxicity	Azienda Ospedaliera S. Maria della Misericordia	Completed	No outcome recorded
—	NCT01885715 Comparator	Jun 2013 → Jun 2014	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT01511627 Comparator	Jan → Jul 2012	—	University of Saskatchewan	Withdrawn	No outcome recorded
—	NCT02419352 Comparator	Sep 2010 → Dec 2015	—	Attikon Hospital	Completed	No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 198 sources stand behind the page.

Field	Value	Cited text
Known as	Neostigmine	“The administration of acetylcholinesterase inhibiting agents (such as neostigmine) has been used to reverse the muscle paralysis induced by non-depolarizing neuromuscular...” NCT04920682 ↗ 197 “Depending on depth of block (subjectively assessed by TOF response), Neostigmine, Sugammadex, or no reversal drug is used to reverse block prior to extubation.” NCT03543826 ↗ “At the end of surgery neuromuscular blocker reversed by neostigmine 50 micg/kg + atropine 20 micg /kg i.v.” NCT05825430 ↗ “Neostigmine 2.5 mg and glycopyrrolate 0,5 mg, iv, single dose, bolus, diluted in 2 ml volume with saline” NCT01142648 ↗ “reversal of the patients was done by injection of neostigmine 0.05mg\\ kg and atropine 0.01mg\\kg.” NCT04365686 ↗ “Administration of calcium chloride 5 mg/kg along with neostigmine 25 mcg/kg + atropine 15 mcg/kg” NCT02213848 ↗ “consists of patients receiving Serratus anterior plane block using Bupivacaine + neostigmine.” NCT05802979 ↗ “Using rocuronium and reversal with neostigmine (1 to 2 mg) and atropine (0.5 to 1 mg)” NCT02648503 ↗ “Intranasal Administration of Neostigmine and Glycopyrrolate for Bowel Evacuation” NCT00855283 ↗ “Intravenous injection of 0.02mg/kg of atropine and 0.03mg/kg of neostigmine” NCT04347486 ↗ “reversal using neostigmine 50 ug/kg and glycopyrrolate 10 ug/kg” NCT04022733 ↗ “neostigmine 0.03 mg/kg and atropine 0.02 mg/kg intravenously” NCT02546843 ↗ “Dose: -Neostigmine: 0.03-0.07 mg/kg by intravenous route.” NCT04096144 ↗ “Neostigmine 3mg and Glycopyrrolate 0.6mg intravenously” NCT01511627 ↗ “Neostigmine: for Arm 1 only (standard use).” NCT05344417 ↗ “Reversal of the block with neostigmine.” NCT02513693 ↗ “Atropine and neostigmine” NCT03943888 ↗ NCT03519724 ↗ NCT06685705 ↗ NCT02909439 ↗ NCT02697929 ↗ NCT06351852 ↗ NCT00451217 ↗ NCT03210376 ↗ NCT03944473 ↗ NCT04905953 ↗ NCT00451100 ↗ NCT03021772 ↗ NCT07666984 ↗ NCT02419352 ↗ NCT05985343 ↗ NCT05342818 ↗ NCT05817019 ↗ NCT05256901 ↗ NCT00847938 ↗ NCT06794450 ↗ NCT03111121 ↗ NCT02455921 ↗ NCT02286752 ↗ NCT02160223 ↗ NCT03939923 ↗ NCT03276026 ↗ NCT03574337 ↗ NCT01539044 ↗ NCT01422304 ↗ NCT04364607 ↗ NCT03904550 ↗ NCT03958201 ↗ NCT02698969 ↗ NCT02454504 ↗ NCT02256280 ↗ NCT06275542 ↗ NCT03316963 ↗ NCT06351995 ↗ NCT06436768 ↗ NCT02037516 ↗ NCT07203287 ↗ NCT03229486 ↗ NCT06729047 ↗ NCT04244097 ↗ NCT07033442 ↗ NCT02375217 ↗ NCT04027972 ↗ NCT05785377 ↗ NCT04951726 ↗ NCT02243943 ↗ NCT07097441 ↗ NCT00779467 ↗ NCT05545280 ↗ NCT01980069 ↗ NCT07524959 ↗ NCT02939430 ↗ NCT04671030 ↗ NCT05116930 ↗ NCT00895609 ↗ NCT04407078 ↗ NCT03923556 ↗ NCT06871033 ↗ NCT02329964 ↗ NCT06228092 ↗ NCT00745095 ↗ NCT03292965 ↗ NCT06081738 ↗ NCT03248648 ↗ NCT06513013 ↗ NCT06982092 ↗ NCT03322657 ↗ NCT03583021 ↗ NCT00473694 ↗ NCT03137290 ↗ NCT06398899 ↗ NCT04570150 ↗ NCT03996655 ↗ NCT03328312 ↗ NCT04910477 ↗ NCT02403063 ↗ NCT03108989 ↗ NCT07309393 ↗ NCT03019835 ↗ NCT01718236 ↗ NCT01885715 ↗ NCT04606901 ↗ NCT03034577 ↗ NCT07253428 ↗ NCT00001520 ↗ NCT04720287 ↗ NCT01479764 ↗ NCT03679611 ↗ NCT03351608 ↗ NCT06678451 ↗ NCT04720573 ↗ NCT01199237 ↗ NCT02666014 ↗ NCT05718934 ↗ NCT04492319 ↗ NCT04258007 ↗ NCT04777383 ↗ NCT06112353 ↗ NCT00825812 ↗ NCT02410590 ↗ NCT04546672 ↗ NCT05898919 ↗ NCT04205097 ↗ NCT04997759 ↗ NCT04565301 ↗ NCT07271875 ↗ NCT04130230 ↗ NCT02543658 ↗ NCT03513406 ↗ NCT04048655 ↗ NCT00724932 ↗ NCT03058263 ↗ NCT05887375 ↗ NCT00676377 ↗ NCT06210165 ↗ NCT02944175 ↗ NCT02370862 ↗ NCT03579589 ↗ NCT05354466 ↗ NCT02845375 ↗ NCT02414880 ↗ NCT02327923 ↗ NCT00675792 ↗ NCT02860507 ↗ NCT04545099 ↗ NCT04873531 ↗ NCT01962298 ↗ NCT04332627 ↗ NCT01809886 ↗ NCT01050543 ↗ NCT03212495 ↗ NCT06055101 ↗ NCT03909165 ↗ NCT02390817 ↗ NCT02574611 ↗ NCT01629394 ↗ NCT02861131 ↗ NCT03505255 ↗ NCT03138967 ↗ NCT03116997 ↗ NCT02752308 ↗ NCT02361060 ↗ NCT02279147 ↗ NCT06787638 ↗ NCT01761552 ↗ NCT04544228 ↗ NCT06136585 ↗ NCT02825576 ↗ NCT03791801 ↗ NCT06501352 ↗ NCT02370433 ↗ NCT05724550 ↗ NCT04161508 ↗ NCT03346070 ↗ NCT02839668 ↗ NCT01134848 ↗ NCT04566796 ↗ NCT02109133 ↗ NCT03346057 ↗ NCT03144453 ↗ NCT01453530 ↗ NCT05037006 ↗ NCT06493838 ↗ NCT05053594 ↗ NCT01748643 ↗ NCT05066035 ↗ NCT02284412 ↗ NCT00407290 ↗ NCT07692282 ↗ NCT03420937 ↗ NCT02215382 ↗ NCT06334562 ↗ NCT03112993 ↗ NCT03519633 ↗ NCT02433808 ↗ NCT05794503 ↗ NCT05993390 ↗ NCT03168308 ↗
Known as	Miostin	“Group B - Neostigmine (Miostin®; Stigmosan®) 0.05 mg/kg and atropine 1 mg/ dose.” NCT03328312 ↗
Known as	NEO	“A group of 6 able-bodied healthy volunteers will receive Neostigmine (NEO) and Glycopyrrolate (GLY) intravenously and via 2 methods of Iontophoresis (ION): one-patch and...” NCT04027972 ↗ 4 “Such measures include the administration of neostigmine (NEO), which increases peristaltic contractions in the colon, resulting in predictable bowel evacuations.” NCT02574611 ↗ “This will be followed by a 2 visit- dose titration study of concomitantly administered, transcutaneous neostigmine methylsulfate (NEO) and glycopyrrolate (GLY).” NCT02370433 ↗ “a medication called neostigmine (NEO) combined with a medication called glycopyrrolate (GLY)” NCT02370862 ↗ “0.03mg/kg neostigmine (NEO) and 0.006mg/kg glycopyrrolate (GLY)” NCT04671030 ↗
Known as	neostigmine methylsulfate	“This will be followed by a 2 visit- dose titration study of concomitantly administered, transcutaneous neostigmine methylsulfate (NEO) and glycopyrrolate (GLY).” NCT02370433 ↗ 2 “Neostigmine Methylsulfate 1 MG/ML” NCT02543658 ↗ “Drug: Neostigmine Methylsulfate” NCT03316963 ↗
Known as	Neostigmine Methylsulphate	“Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.” NCT06493838 ↗
Known as	Stigmosan	“Group B - Neostigmine (Miostin®; Stigmosan®) 0.05 mg/kg and atropine 1 mg/ dose.” NCT03328312 ↗
Action	Inhibit	“inhibits the hydrolysis of acetylcholine by competing with acetylcholine for attachment to acetylcholinesterase” NCT00001520 ↗
Modality	Other / unclassified	“Neostigmine is an anticholinesterase agent” NCT00001520 ↗
Route	Other	“Neostigmine Group : epidural injection of Ropivacaine and Neostigmine” NCT00407290 ↗