A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery

NCT01980069 ↗

Completed 72 enrolled Yonsei University

RandomizedParallel-groupDouble-blindTreatment

Summary

Investigators hypothesized that the surgical condition will be improved with the use of sugammadex in patients undergoing laryngeal microsurgery. Investigators will compare the effect of sugammadex and neostigmine on the surgical condition during laryngeal microsurgery.

Timeline

Start: 2013-11
Primary completion: 2014-10
Completion: 2014-10

Publications

Kim HJ, Lee K, Park WK, Lee BR, Joo HM, Koh YW, Seo YW, Kim WS, Yoo YC. Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery. Br J Anaesth. 2015 Dec;115(6):867-72. doi: 10.1093/bja/aev368.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Neostigmine	Other / unclassified	50 ug/kg	Intravenous
Comparator	Sugammadex	Other / unclassified	2 mg/kg	Intravenous
Comparator	Sugammadex	Other / unclassified	4 mg/kg	Intravenous
Comparator	Sugammadex	Other / unclassified	8 mg/kg	Intravenous
Background	Glycopyrrolate	Small molecule	10 ug/kg	—

Indications

No indication recorded.