Drugs / Sugammadex
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Sugammadex

Other / unclassified

Developed for
curariform drugs toxicity · morbid obesity · neuromuscular disease · obstructive sleep apnea syndrome · ileus · cranial nerves, recurrent paresis of · delirium · intestinal dysmotility syndrome
+10 more · lung disorder · myopathy · pulmonary immaturity · respiratory paralysis · respiratory system disorder · urinary bladder disorder · urinary tract obstruction · voice disorders · intestinal disorder · ocular hypotension
Investigated by
Merck Sharp & Dohme LLC · Seoul National University Hospital · Guangzhou General Hospital of Guangzhou Military Command · Yonsei University · Ajou University School of Medicine · Onze Lieve Vrouw Hospital
+103 more · Seoul National University Bundang Hospital · University Hospital Olomouc · University of Washington · Brno University Hospital · Campus-Bio-Medico University · Emory University · Korea University Anam Hospital · Leiden University Medical Center · M.D. Anderson Cancer Center · MSD Belgium BVBA · MSD Korea Ltd. · Mansoura University · Ministry of Food and Drug Safety, Korea · Oregon Health and Science University · Palacky University · Technical University of Munich · The Cleveland Clinic · Universitaire Ziekenhuizen KU Leuven · University of Missouri-Columbia · University of South Florida · Ain Shams University · Alexandria University · Baskent University · Beijing Tiantan Hospital · Beijing Tongren Hospital · Central Clinical Hospital #1 of LLC Russian Railways · Central Hospital, Nancy, France · Centro Hospitalar do Porto · Chang Gung Memorial Hospital · Chulalongkorn University · Ciusss de L'Est de l'Île de Montréal · Clayton Petro · Diskapi Teaching and Research Hospital · Endeavor Health · Enrique Alday Muñoz · Erasme University Hospital · Faculdade de Ciências Médicas da Santa Casa de São Paulo · Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Federal University of São Paulo · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia · Georgia Clinical & Translational Science Alliance · Guangdong Provincial Hospital of Traditional Chinese Medicine · Hadassah Medical Organization · Hopital Foch · Hospital General Universitario Santa Lucía · Hospital Sultanah Aminah Johor Bahru · Hospital Universitario Santa Maria del Rosell · Hospital Universitario Virgen de la Arrixaca · IGA - internal grant agency, Ministry of Health · KDCHOT FN Brno · Kaohsiung Medical University Chung-Ho Memorial Hospital · Korea University Ansan Hospital · Lütfiye Nuri Burat Government Hospital · Masaryk Hospital Usti nad Labem · Mayo Clinic · McMaster University · Medipol University · Merck Canada Inc. · Montefiore Medical Center · National Cancer Institute, Egypt · National Center for Advancing Translational Sciences (NCATS) · National Taiwan University Hospital · Padjadjaran University · Peking Union Medical College Hospital · Poitiers University Hospital · Pusan National University Yangsan Hospital · Radboud University Medical Center · Regina Elena Cancer Institute · Respiratory Motion, Inc. · Rhendra Hardy Mohamad Zaini · Rigshospitalet, Denmark · SMG-SNU Boramae Medical Center · all 109 on the full record

Regulatory milestones approvals, filings & regulatory actions · 6 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (4) US (FDA) BRIDION 2020-06-09 – 2024-12-12 fda.gov
Approved US (FDA) BRIDION 2015-12-15 fda.gov
Approved EU (EMA) Bridion 2008-07-25 europa.eu

Trials 159 · started per year

today
EU approved 2008
US approved 2015
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20032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT04556721 Sep 2021 kidney disorder Tetsuro Sakai Withdrawn No outcome recorded
Phase 1 NCT02028065 Jan → Jul 2014 anaphylaxis Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT02011490 Dec 2013 → Jun 2014 impaired renal function disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT00988065 Sep 2009 → Apr 2010 hypersensitivity reaction disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT06794450 Nov 2024 → Feb 2025 overdue curariform drugs toxicity Padjadjaran University Recruiting No outcome recorded
Phase 217 trials
Phase 2 NCT06575036 Sep 2024 → Apr 2025 overdue Sang-Hwan Ji Not yet recruiting No outcome recorded
Phase 2 NCT05723406 Mar → Nov 2023 osteoarthritis, hip Radboud University Medical Center Completed No outcome recorded
Phase 2 NCT04347486 Apr 2020 → Dec 2021 Seoul National University Hospital Completed No outcome recorded
Phase 2 NCT03943888 Aug 2019 → Feb 2020 Seoul National University Hospital Completed No outcome recorded
Phase 2 NCT03532178 Jan 2019 → Mar 2022 University of California, San Francisco Completed No outcome recorded
Phase 2 NCT03519724 Jul → Sep 2018 curariform drugs toxicity Campus-Bio-Medico University Unknown No outcome recorded
Phase 2 NCT03519633 Apr 2018 → Dec 2024 curariform drugs toxicity Campus-Bio-Medico University Completed No outcome recorded
Phase 2 NCT02545595 May 2012 → Dec 2013 morbid obesity Poitiers University Hospital Completed No outcome recorded
Phase 2 NCT01911520 Jan 2011 → Jun 2012 morbid obesity University Hospital, Ghent Completed No outcome recorded
Phase 2 NCT00591409 Jan → Sep 2006 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03728543 Nov 2018 → Nov 2019 beta thalassemia, childhood malignant neoplasm, hepatoblastoma Federal Research Institute of Pediatric Hematology, Oncology and Immunology Unknown No outcome recorded
Phase 332 trials
Phase 3 NCT07271875 Jan 2026 → Nov 2027 expected ileus, intestinal dysmotility syndrome Xijing Hospital Not yet recruiting No outcome recorded
Phase 3 NCT06136585 Jun 2024 → Oct 2026 expected The Cleveland Clinic Recruiting No outcome recorded
Phase 3 NCT05801679 Jul 2023 → Jul 2025 Endeavor Health Completed No outcome recorded
Phase 3 NCT05276804 Apr 2022 → Sep 2024 urinary bladder disorder Wake Forest University Health Sciences Completed No outcome recorded
Phase 3 NCT04854993 Jul 2021 → Sep 2022 prostate cancer Fondazione Policlinico Universitario Agostino Gemelli IRCCS Completed No outcome recorded
Phase 3 NCT04096144 Oct 2019 → Mar 2020 overdue University of South Florida Not yet recruiting No outcome recorded
Phase 3 NCT03196791 Oct 2017 → Aug 2020 gastric cancer, obesity disorder Korea University Anam Hospital Completed No outcome recorded
Phase 3 NCT01570179 May → Jul 2012 Central Hospital, Nancy, France Completed No outcome recorded
Phase 3 NCT01509651 Jan → Mar 2012 Onze Lieve Vrouw Hospital Completed No outcome recorded
Phase 3 NCT01479764 Dec 2011 → Oct 2012 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 470 trials
Phase 4 NCT07477132 Mar 2026 → Aug 2027 expected curariform drugs toxicity University Hospital, Caen Not yet recruiting No outcome recorded
Phase 4 NCT05985343 Jan 2024 → May 2025 abdominal wall malformation, ileus Clayton Petro Completed No outcome recorded
Phase 4 NCT05887375 Aug 2023 → Jan 2026 urinary tract obstruction University of Missouri-Columbia Completed No outcome recorded
Phase 4 NCT05661409 Jul 2023 → Aug 2024 Emory University Completed No outcome recorded
Phase 4 NCT05256901 Jul 2023 → Jul 2024 appendicitis Emory University Terminated No outcome recorded
Phase 4 NCT05817019 Apr 2023 → Dec 2024 COVID-19 Korea University Ansan Hospital Unknown No outcome recorded
Phase 4 NCT05718934 Nov 2022 → Dec 2023 Ciusss de L'Est de l'Île de Montréal Completed No outcome recorded
Phase 4 NCT05354466 Jun 2022 → Sep 2024 respiratory system disorder Seoul National University Hospital Completed No outcome recorded
Phase 4 NCT05328778 Apr 2022 → Jan 2025 Guangzhou General Hospital of Guangzhou Military Command Completed No outcome recorded
Phase 4 NCT04263363 Feb 2022 → May 2024 obstructive sleep apnea syndrome University of California, Los Angeles Completed No outcome recorded
Phase not applicable34 trials
NCT07534475 Apr → May 2026 overdue bipolar disorder, major depressive disorder, schizophrenia Medipol University Not yet recruiting No outcome recorded
NCT07309393 Dec 2025 → Sep 2026 expected Shanghai Pulmonary Hospital, Shanghai, China Recruiting No outcome recorded
NCT06962007 Jul 2025 → Sep 2026 expected facial spasm Wonkwang University Hospital Recruiting No outcome recorded
NCT06634355 Mar 2025 → Sep 2026 expected pregnancy disorder Universitaire Ziekenhuizen KU Leuven Enrolling by invitation No outcome recorded
NCT06678451 Dec 2024 → May 2025 overdue Shanxi Bethune Hospital Not yet recruiting No outcome recorded
NCT05751603 Oct 2024 → Oct 2025 overdue Ajou University School of Medicine Not yet recruiting No outcome recorded
NCT06436768 Jun 2024 → Mar 2025 Beijing Tongren Hospital Completed No outcome recorded
NCT06334562 Jun 2024 → Dec 2025 overdue The Fourth Affiliated Hospital of Zhejiang University School of Medicine Recruiting No outcome recorded
NCT06398899 May 2024 → Jun 2025 chronic otitis media, chronic rhinosinusitis, laryngeal disorder National Taiwan University Hospital Completed No outcome recorded
NCT05993390 Jan 2024 → Aug 2027 expected Seoul National University Hospital Recruiting No outcome recorded
Also used as a comparator or background therapy in 83 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03328312 Comparator Dec 2017 → Mar 2018 curariform drugs toxicity Iuliu Hatieganu University of Medicine and Pharmacy Unknown No outcome recorded
Phase 13 trials
Phase 1 NCT06982092 Comparator Aug 2024 → Jan 2025 Ain Shams University Completed No outcome recorded
Phase 1 NCT03579589 Comparator Aug 2018 → Dec 2019 Ohio State University Completed No outcome recorded
Phase 1 NCT02888067 Comparator Jul 2017 → Jul 2022 Thomas Schricker Terminated No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT05664633 Comparator Aug 2023 → Jun 2024 urinary bladder disorder West Virginia University Withdrawn No outcome recorded
Phase 22 trials
Phase 2 NCT03904550 Comparator Dec 2019 → Aug 2022 impaired renal function disease University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 2 NCT03448068 Background Apr 2018 → Jan 2020 Mayo Clinic Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT01937247 Comparator May 2018 → Oct 2020 American University of Beirut Medical Center Completed No outcome recorded
Phase 2/3 NCT02147054 Comparator May 2014 → Jul 2016 organophosphate poisoning University of Edinburgh Completed No outcome recorded
Phase 2/3 NCT01629394 Comparator Jan → Oct 2012 morbid obesity University of Patras Unknown No outcome recorded
Phase 37 trials
Phase 3 NCT03513406 Comparator Mar 2018 → Mar 2023 University of Kansas Medical Center Completed No outcome recorded
Phase 3 NCT03116997 Comparator Apr 2017 → Mar 2022 Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 3 NCT02666014 Comparator Jun 2015 → Dec 2017 KK Women's and Children's Hospital Completed No outcome recorded
Phase 3 NCT02713113 Comparator Mar 2015 → Feb 2016 Assiut University Completed No outcome recorded
Phase 3 NCT01962298 Comparator Oct 2013 → Dec 2014 diaphragm disorder, myopathy University Hospital, Antwerp Completed No outcome recorded
Phase 445 trials
Phase 4 NCT07666984 Comparator Jun → Jul 2026 overdue Cukurova University Recruiting No outcome recorded
Phase 4 NCT07203287 Comparator Aug 2025 → Dec 2026 expected The University of Texas Medical Branch, Galveston Recruiting No outcome recorded
Phase 4 NCT06112353 Comparator Apr 2024 → Jul 2026 overdue intestinal disorder University of California, Irvine Recruiting No outcome recorded
Phase 4 NCT06225466 Comparator Apr → Sep 2024 University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 4 NCT06228092 Comparator Dec 2023 → May 2025 curariform drugs toxicity Matias Vested Completed No outcome recorded
Phase not applicable21 trials
NCT07092046 Comparator Aug 2025 Ankara City Hospital Bilkent Completed No outcome recorded
NCT06553066 Background Aug 2024 → Aug 2026 overdue University Hospital of Patras Not yet recruiting No outcome recorded
NCT05344417 Background Mar 2024 → Dec 2026 expected ileus Ohio State University Recruiting No outcome recorded
NCT04944303 Comparator Dec 2020 → Apr 2021 Second Affiliated Hospital of Guangzhou Medical University Completed No outcome recorded
NCT04471376 Comparator Jul → Dec 2020 Beijing Tiantan Hospital Completed No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 245 sources stand behind the page.

FieldValueCited text
Known as Sugammadex Sugammadex is a modified cyclodextrin that forms complexes with rocuronium, reducing free plasma concentrations of rocuronium and reversing its neuromuscular blocking action...” NCT02794714
238

“At the end of surgery, deep Block patients' will receive 4 mg/kg sugammadex and the patient's trachea will be extubated according to routine extubation criteria.” NCT03591289

“Depending on depth of block (subjectively assessed by TOF response), Neostigmine, Sugammadex, or no reversal drug is used to reverse block prior to extubation.” NCT03543826

Sugammadex is a modified γ-cyclodextrin that reverses the effect of the steroidal nondepolarizing neuromuscular blocking agents rocuronium and vecuronium (2).” NCT03791801

Sugammadex is administered at the end of surgery after assessment of the level of neuromuscular blockade is done.” NCT06035757

“Used for Neuromuscular reversal; Sugammadex is devoid of the parasympathetic effects caused by Neostigmine.” NCT04096144

“After the end of surgery, sugammadex of 4 mg/kg will be administered to reverse neuromuscular blockade.” NCT02762890

“Reversal of the TOF=2 will be done by Sugammadex 2 mg/kg at end of procedure (Time of last suture)” NCT03643913

“Specific Neuromuscular Blockade reversal will be performed with Sugammadex intravenously.” NCT02546843

sugammadex 4 mg/kg are administered IV for reversal of neuromuscular block” NCT02100280

“At the end of surgery, IV Sugammadex (Bridion®, Merck Sharp and Dohme” NCT03871387

“reversal using sugammadex 4 mg/kg based on actual body weight” NCT04022733

Sugammadex: will be used for the other arms in the study.” NCT05344417

sugammadex 2mg/kg or 4 mg/kg dose depending on twitch” NCT03448068

“Using rocuronium and reversal with sugammadexNCT02648503

“Reversal of the block with sugammadex.” NCT02513693

“Rocuronium and SugammadexNCT06553066

NCT00559468

NCT05354466

NCT05028088

NCT03196791

NCT00591409

NCT07309393

NCT03138967

NCT05246397

NCT03909165

NCT02708056

NCT07534475

NCT00988065

NCT04471376

NCT01972659

NCT03196167

NCT01728584

NCT03958201

NCT02410590

NCT04546672

NCT03911232

NCT03795259

NCT02939430

NCT03116997

NCT03369782

NCT01422304

NCT03292965

NCT03346070

NCT05724550

NCT03137290

NCT02247466

NCT02728726

NCT02011490

NCT01564576

NCT01761552

NCT02375217

NCT02944175

NCT02243943

NCT04566796

NCT04997759

NCT01453530

NCT04263363

NCT00751179

NCT02580188

NCT02414880

NCT01142648

NCT00675792

NCT04570150

NCT05328778

NCT04545099

NCT01902641

NCT00591786

NCT02390817

NCT03229486

NCT00826176

NCT03351608

NCT06136585

NCT05723406

NCT03322657

NCT02329964

NCT02568345

NCT01539044

NCT04556721

NCT06081738

NCT00420680

NCT07666984

NCT01161004

NCT01933425

NCT05751603

NCT00473694

NCT01570179

NCT02455921

NCT00482599

NCT02825576

NCT03904550

NCT03435003

NCT00825812

NCT04161508

NCT04407078

NCT03574337

NCT01424488

NCT00421148

NCT06794450

NCT06982092

NCT02724111

NCT05040490

NCT04332627

NCT05985343

NCT00552929

NCT02079337

NCT02454504

NCT06398899

NCT01785758

NCT00552617

NCT02510157

NCT03513406

NCT06634355

NCT03728543

NCT07203287

NCT04720573

NCT02284412

NCT04854993

NCT01479764

NCT02109133

NCT01937247

NCT00702715

NCT00758485

NCT00298831

NCT05545280

NCT02147054

NCT03144453

NCT00474253

NCT03381209

NCT01050543

NCT06228092

NCT04258007

NCT03460509

NCT05817019

NCT02666014

NCT03226080

NCT03515694

NCT00451217

NCT03108989

NCT03944473

NCT00953550

NCT00451100

NCT02419352

NCT01509651

NCT02028065

NCT03112993

NCT03519724

NCT05256901

NCT02451202

NCT03943888

NCT04131218

NCT02403063

NCT02286752

NCT03519854

NCT05993390

NCT02215382

NCT03034577

NCT01579851

NCT03087513

NCT04944303

NCT01301261

NCT05202899

NCT06112353

NCT00474617

NCT03168308

NCT03039543

NCT05664633

NCT03420937

NCT03579589

NCT01718236

NCT05276804

NCT05313100

NCT03923556

NCT02769325

NCT03519633

NCT05801679

NCT01911520

NCT06225466

NCT04205097

NCT07092046

NCT02909439

NCT03346057

NCT03939923

NCT07477132

NCT02160223

NCT02484651

NCT03634956

NCT00656799

NCT00535496

NCT00535743

NCT06678451

NCT02545595

NCT03679611

NCT01980069

NCT01855217

NCT00724932

NCT01101139

NCT06210165

NCT03689413

NCT04347486

NCT03583021

NCT03532178

NCT05718934

NCT02256280

NCT03111121

NCT00475215

NCT04606901

NCT03210376

NCT01748643

NCT02861131

NCT01629394

NCT04608682

NCT02860507

NCT01965067

NCT00895609

NCT02845375

NCT07271875

NCT05661409

NCT03328312

NCT01503840

NCT01809886

NCT02698969

NCT06575036

NCT02713113

NCT05066035

NCT06334562

NCT05794503

NCT01890057

NCT03996655

NCT05187455

NCT06436768

NCT03276026

NCT05887375

NCT06962007

NCT02361060

NCT02697929

NCT01962298

NCT03803982

NCT00379613

Known as Bridion “In sugammadex group, sugammadex (Bridion, Merck Shart and Dohme (MSD), Oss, the Netherlands) will be administered intravenously in different doses according to the degree of...” NCT01980069
11

“At present, the introduction of sugammadex (Bridion®), an antagonist of nondepolarizing the neuromuscular relaxant rocuronium, may lead to an extraordinary breakthrough.” NCT01809886

“Sugammadex (Bridion®) is a novel drug which selectively binds rocuronium (Esmeron®).” NCT01911520

“Rocuronium: Zemuron. Sugammadex: Bridion. Succinylcholine: Suxamethonium” NCT03532178

“At the end of surgery, IV Sugammadex (Bridion®, Merck Sharp and Dohme” NCT03871387

“Group A - Sugammadex (Bridion®) 2 mg/kg,” NCT03328312

“Sugammadex Injection [Bridion]” NCT03087513

“Sugammadex (tradename Bridion)” NCT01761552

“Sugammadex Injection [Bridion]” NCT03229486

“Sugammadex Injection [Bridion]” NCT03996655

“Sugammadex Injection [Bridion]” NCT03515694

“sugammadex, BridionNCT01564576

Known as HengShu, Sugammadex sodium HengShu, Sugammadex sodiumNCT07309393
Known as MK-8616 “sugammadex (Org 25969; MK-8616)” NCT03519854
1

NCT03519867

Known as Org 25969 “sugammadex (Org 25969; MK-8616)” NCT03519854
Known as Org 25969, Bridion Org 25969, Bridion®” NCT00826176
Known as SUG Sugammadex (SUG) is a novel-specific antagonist of aminosteroidal muscle relaxants, which can effectively antagonise muscle relaxants at different depths.” PMID 35105573 Feb 2022
Known as Sugammadex adroiq ChEMBL registry synonym — accepted as the source's own label CHEMBL2111107
Known as Sugammadex amomed ChEMBL registry synonym — accepted as the source's own label CHEMBL2111107
Known as Sugammadex fresenius kabi ChEMBL registry synonym — accepted as the source's own label CHEMBL2111107
Known as Sugammadex mylan ChEMBL registry synonym — accepted as the source's own label CHEMBL2111107
Known as Sugammadex octasodium salt ChEMBL registry synonym — accepted as the source's own label CHEMBL2111107
Known as Sugammadex piramal ChEMBL registry synonym — accepted as the source's own label CHEMBL2111107
Known as sugammadex sodium “This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium.” NCT04347486
3

“Drug: Sugammadex SodiumNCT03196791

NCT02888067

NCT05468671

Known as sugammadex: Bridion sugammadex: BridionNCT01748643
Action Inhibit “Sugammadex, a cyclodextrin molecule that encapsulates and inactivates rocuronium and vecuronium” NCT01748643
Modality Other / unclassified “sugammadex, a modified gamma-cyclodextrin derivative” PMID 17667567 Aug 2007
Route Intravenous “sugammadex 2.0 to 16.0 mg/kg IV was administered” NCT00379613