drugset / Trial / NCT01962298
Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
RandomizedParallel-groupTriple-blindTreatment
Summary
The effect of neuromuscular blocking agents (NMBA, e.g. rocuronium) on respiratory muscle activity is well known. However, since the availability of sugammadex, to our knowledge, no study has been conducted to evaluate the effect of this novel product on these muscles. Our hypothesis is that by applying a different strategy in the use of neuromuscular blocking agents and their reversal agents we might see a different activity of the respiratory muscles.
Timeline
- Start
- 2013-10
- Primary completion
- 2014-12
- Completion
- 2014-12
Publications
- Background Dres M, Schmidt M, Ferre A, Mayaux J, Similowski T, Demoule A. Diaphragm electromyographic activity as a predictor of weaning failure. Intensive Care Med. 2012 Dec;38(12):2017-25. doi: 10.1007/s00134-012-2700-3. Epub 2012 Sep 26.
- Schepens T, Janssens K, Maes S, Wildemeersch D, Vellinga J, Jorens PG, Saldien V. Respiratory muscle activity after spontaneous, neostigmine- or sugammadex-enhanced recovery of neuromuscular blockade: a double blind prospective randomized controlled trial. BMC Anesthesiol. 2019 Oct 19;19(1):187. doi: 10.1186/s12871-019-0863-y.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Neostigmine | Other / unclassified | 70 ug/kg | — |
| Comparator | Rocuronium | Other / unclassified | — | — |
| Comparator | Sugammadex | Other / unclassified | 2 mg/kg | — |
| Comparator | Sugammadex | Other / unclassified | 4 mg/kg | — |