"Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"

Phase 4 Completed 56 enrolled American University of Beirut Medical Center

RandomizedParallel-groupTriple-blindTreatment

Summary

Prospective Randomized non inferiority Trial involving adult patients undergoing elective surgery under general anesthesia.56 Patients will be enrolled in 2 groups : full dose sugammadex vs half dose sugammadex for reversal of NMB.

Timeline

Start: 2014-10
Primary completion: 2015-10
Completion: 2015-10

Publications

Aouad MT, Alfahel WS, Kaddoum RN, Siddik-Sayyid SM. Half dose sugammadex combined with neostigmine is non-inferior to full dose sugammadex for reversal of rocuronium-induced deep neuromuscular blockade: a cost-saving strategy. BMC Anesthesiol. 2017 Apr 11;17(1):57. doi: 10.1186/s12871-017-0348-9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Neostigmine	Other / unclassified	50 ug/kg	Intravenous
Comparator	Sugammadex	Other / unclassified	1 mg/kg	Intravenous
Comparator	Sugammadex	Other / unclassified	2 mg/kg	Intravenous
Comparator	Sugammadex	Other / unclassified	4 mg/kg	Intravenous
Comparator	Glycopyrrolate	Small molecule	10 ug/kg	—

Indications

No indication recorded.