Neostigmine/Glyco-pyrrolate 50 Mikrogram/kg or Sugammadex 2 mg/kg for Reversal of Neuromuscular Blockade in Elderly Patients

Summary

The aim of this study is to determine the time to TOF ≥ 0.9 after either neostigmine/glycopyrrolate 50 mikrogr/kg or sugammadex 2 mg/kg in patients with age ≥ 75 years. The hypothesis of this study is that sugammadex 2 mg/kg provides a faster time to TOF ≥ 0.9 compared to neostigmine/glycopyrrolate 50 mikrogr/kg.

Timeline

Start

2023-12-04

Primary completion

2025-05-04

Completion

2025-05-04

Publications

• Vested M, Wadland SS, Christensen MI, Creutzburg A, Madsen KPD, Tsuchiya EA, Madsen BG, Rovsing ML, Meyhoff CS, Lindelof K, Afshari A, Rasmussen LS. Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade in Elderly Patients: A Blinded Randomised Study. Acta Anaesthesiol Scand. 2026 Jan;70(1):e70160. doi: 10.1111/aas.70160.

Drugs

Indications