Effectiveness of Sugammadex in LMS Surgery

Phase 4 Unknown 80 enrolled Korea University Anam Hospital

RandomizedParallel-groupDouble-blindSupportive care

Summary

This study is comparing of rocuronium-sugammadex and succinylcholine during LMS surgery that is characterized by short operation time, required intense paralysis and ambulatory setting, has not been investigated.

Timeline

Start: 2015-02
Primary completion: 2015-08
Completion: 2016-09

Outcome

Met primary endpoint

paper Reversal of profound high-dose rocuronium-induced neuromuscular block (1.2 mg/kg) with 16 mg/kg sugammadex was significantly faster than spontaneous recovery from 1 mg/kg succinylcholine. PMID 19387176 ↗

Publications

Results Lee C, Jahr JS, Candiotti KA, Warriner B, Zornow MH, Naguib M. Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine. Anesthesiology. 2009 May;110(5):1020-5. doi: 10.1097/ALN.0b013e31819dabb0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Neostigmine	Other / unclassified	0.2 mg/kg	—
Subject	Sugammadex	Other / unclassified	2 mg/kg	—

Indications

No indication recorded.