Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Phase 4 Completed 83 enrolled Stony Brook University

RandomizedParallel-groupSingle-blindPrevention

Summary

Bariatric surgery remains the most effective therapy for obesity. Postoperative nausea and vomiting (PONV) are commonly reported following bariatric surgery. The proposed study focuses on the most common bariatric procedure performed, laparoscopic sleeve gastrectomy (LSG), and aims to assess the effect of a post-operative nausea and vomiting-specific intervention. The investigators hypothesize that the intervention group will experience a reduction of nausea-related prolonged hospital stay and significantly improve patient-reported quality of recovery from surgery and quality of life.

Timeline

Start: 2017-08-28
Primary completion: 2019-03-30
Completion: 2019-04-01

Publications

Naeem Z, Nie L, Drakos P, Yang J, Gan TJ, Pryor AD, Spaniolas K. The Relationship Between Postoperative Nausea and Vomiting and Early Self-Rated Quality of Life Following Laparoscopic Sleeve Gastrectomy. J Gastrointest Surg. 2021 Aug;25(8):2107-2109. doi: 10.1007/s11605-021-04923-4. Epub 2021 Feb 2. No abstract available.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aprepitant	Other / unclassified	80 mg	Oral
Subject	Scopolamine	Unknown	—	Topical
Comparator	Desflurane	Other / unclassified	—	Inhaled
Background	Dexamethasone	Small molecule	8 mg	Intravenous
Background	Dexmedetomidine	Other / unclassified	—	—
Background	Fentanyl	Other / unclassified	—	—
Background	Metoclopramide	Small molecule	—	—
Background	Ondansetron	Other / unclassified	4 mg	Intravenous
Background	Prochlorperazine	Small molecule	—	—
Background	Propofol	Small molecule	—	Intravenous
Comparator	Sevoflurane	Other / unclassified	—	Inhaled
Background	Sugammadex	Other / unclassified	2 mg/kg	Intravenous
Background	Sugammadex	Other / unclassified	4 mg/kg	Intravenous

Indications

No indication recorded.