Desflurane

also known as desflurane (Suprane(R), Baxter Healthcare) · Desflurano · I-653 · Suprane · Suprane (desflurane, USP)

Other / unclassified targets CDC42, CLOCK, KCNK10, KCNK18, KCNK2, KCNK3, KCNK9 via activation

Developed for: delirium · coronary artery disorder · aortic valve stenosis · cognitive disorder · ischemic disease · pediatric acute respiratory distress syndrome · subjective cognitive decline · acute lung injury
+1 more
· non-small cell lung carcinoma
Investigated by: Yonsei University · Kangbuk Samsung Hospital · Seoul National University Hospital · Baxter Healthcare Corporation · Beijing Tiantan Hospital · Cantonal Hospital of St. Gallen
+79 more
· Medical University of Gdansk · Medical University of Vienna · Ruhr University of Bochum · University of Zurich · Ain Shams University · Ajou University School of Medicine · All India Institute of Medical Sciences · All India Institute of Medical Sciences, Raebareli, UP · Aristotle University Of Thessaloniki · Assistance Publique - Hôpitaux de Paris · Ataturk University · Baskent University Ankara Hospital · Begoña Quintana Villamandos · Beijing Chao Yang Hospital · C. R. Bard · Centre Hospitalier Universitaire Vaudois · Chiang Mai University · Chih-Cheng Hung · Children's Hospital Medical Center, Cincinnati · DongGuk University · Eye & ENT Hospital of Fudan University · Fondation Apicil · Gachon University Gil Medical Center · Gangnam Severance Hospital · Georgia Tsaousi · German Federal Ministry of Education and Research · Harran University · Huazhong University of Science and Technology · Inje University · Insel Gruppe AG, University Hospital Bern · Kantonsspital Münsterlingen · Kantonsspital Winterthur KSW · Keimyung University Dongsan Medical Center · Kocaeli City Hospital · Konkuk University Medical Center · Konya City Hospital · Ludwig-Maximilians - University of Munich · Mahidol University · Malaysian Society of Anaesthesiologists · Medical University Innsbruck · Menoufia University · Mercy Facial Plastic Surgery Center · Muğla Sıtkı Koçman University · Nanjing Medical University · National and Kapodistrian University of Athens · Nobuyuki Katori · Ohio State University · Prince of Songkla University · Pusan National University Yangsan Hospital · RWTH Aachen University · Saint Savvas Anticancer Hospital · Sefako Makgatho Health Sciences University · Shengjing Hospital · Sichuan Provincial People's Hospital · Stony Brook University · Tam Anh Research Institute · Tam Anh TP. Ho Chi Minh General Hospital · The Catholic University of Korea · The Cleveland Clinic · The Second Affiliated Hospital of Chongqing Medical University · Theodor Bilharz Research Institute · Tianjin First Central Hospital · Tokyo Women's Medical University · Trakya University · Triemli Hospital · Ufuk University · Universiti Sains Malaysia · University Hospital Hradec Kralove · University Hospital, Basel, Switzerland · University Hospital, Clermont-Ferrand · University of Malaya · University of Melbourne · Vita-Salute San Raffaele University · West China Hospital · all 85 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	SUPRANE	—	2006-12-15	fda.gov ↗
Approved	US (FDA)	SUPRANE	—	1992-09-18	fda.gov ↗

Trials 94 · started per year

today

US approved 1992

1992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT06241131	Mar → Dec 2024	—	Sichuan Provincial People's Hospital	Unknown	No outcome recorded
Phase 0	NCT05246371	Jun → Nov 2021	—	Ain Shams University	Unknown	No outcome recorded
Phase 1/21 trial
Phase 1/2	NCT04771962	Jan 2020 → Dec 2021	—	Universiti Sains Malaysia	Completed	No outcome recorded
Phase 22 trials
Phase 2	NCT02559297	Aug 2015 → Jun 2017	—	Mahidol University	Completed	No outcome recorded
Phase 2	NCT02036736	Apr 2013 → Dec 2014	—	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 2/31 trial
Phase 2/3	NCT00762372	Feb → Aug 2008	—	Baxter Healthcare Corporation	Completed	No outcome recorded
Phase 37 trials
Phase 3	NCT07116733	Oct 2025 → Dec 2028 expected	—	Xijing Hospital	Recruiting	No outcome recorded
Phase 3	NCT03618082	Jun 2019 → May 2022	—	University Hospital, Clermont-Ferrand	Unknown	No outcome recorded
Phase 3	NCT02872389	Aug → Dec 2016	—	Kangbuk Samsung Hospital	Completed	No outcome recorded
Phase 3	NCT02830243	Jul → Oct 2016	—	Kangbuk Samsung Hospital	Completed	No outcome recorded
Phase 3	NCT02698514	Feb → Jul 2016	—	Kangbuk Samsung Hospital	Completed	No outcome recorded
Phase 3	NCT02609802	Nov 2015 → Jul 2016	musculoskeletal system disorder	Kangbuk Samsung Hospital	Completed	No outcome recorded
Phase 3	NCT02322502	Feb 2015 → Feb 2016	—	RWTH Aachen University	Completed	No outcome recorded
Phase 425 trials
Phase 4	NCT07123870	Jul → Oct 2025 overdue	—	Kocaeli City Hospital	Recruiting	No outcome recorded
Phase 4	NCT06779890	May 2025 → Sep 2026 expected	brain edema	Georgia Tsaousi	Recruiting	No outcome recorded
Phase 4	NCT07359508	Jan 2024 → Jun 2025	—	All India Institute of Medical Sciences	Completed	No outcome recorded
Phase 4	NCT05990790	Sep 2023 → Dec 2027 expected	delirium	Medical University of Vienna	Recruiting	No outcome recorded
Phase 4	NCT05783518	Mar → Oct 2023	biliary atresia, pediatric acute respiratory distress syndrome	Tianjin First Central Hospital	Unknown	No outcome recorded
Phase 4	NCT05331027	May 2022 → Jun 2023	delirium	Medical University of Vienna	Completed	No outcome recorded
Phase 4	NCT04541823	May 2021 → Dec 2022	delirium	Beijing Chao Yang Hospital	Unknown	No outcome recorded
Phase 4	NCT03917186	Sep 2017 → Dec 2020	kidney failure	Begoña Quintana Villamandos	Completed	No outcome recorded
Phase 4	NCT03194074	Aug 2017 → Jun 2019	cognitive disorder	Eye & ENT Hospital of Fudan University	Unknown	No outcome recorded
Phase 4	NCT03209193	Jul 2017 → Nov 2019	—	Seoul National University Hospital	Completed	No outcome recorded
Phase 4	NCT03034096	Jan 2017 → Sep 2024	—	Stony Brook University	Completed	No outcome recorded
Phase 4	NCT02335151	Oct 2016 → Sep 2019	adenocarcinoma, pancreatic neoplasm	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03006250	Aug 2016 → Jul 2019	respiratory system disorder	Chiang Mai University	Unknown	No outcome recorded
Phase 4	NCT02834845	Jun → Aug 2016	—	Ufuk University	Completed	No outcome recorded
Phase 4	NCT02717780	Feb 2016 → Jun 2018	obstructive sleep apnea syndrome	Centre Hospitalier Universitaire Vaudois	Completed	No outcome recorded
Phase 4	NCT02213718	Jul 2014 → Jan 2017	coronary restenosis, local anesthetic poisoning	Huazhong University of Science and Technology	Unknown	No outcome recorded
Phase 4	NCT02504138	Jun 2014 → May 2017	liver failure	Yonsei University	Completed	No outcome recorded
Phase 4	NCT02105610	Apr 2014 → Oct 2017	—	Vita-Salute San Raffaele University	Completed	No outcome recorded
Phase 4	NCT01985854	Jan 2014 → Dec 2016	—	Tokyo Women's Medical University	Unknown	No outcome recorded
Phase 4	NCT02019797	Jan 2014 → Dec 2015	aortic valve stenosis	Nobuyuki Katori	Unknown	No outcome recorded
Phase 4	NCT01870011	Dec 2013 → Nov 2014	end stage renal failure	Yonsei University	Completed	No outcome recorded
Phase 4	NCT01886664	Dec 2012 → Nov 2013	—	Seoul National University Hospital	Completed	No outcome recorded
Phase 4	NCT01452256	Dec 2011 → Dec 2014	—	University of Zurich	Completed	No outcome recorded
Phase 4	NCT01486953	Nov 2011 → Apr 2014	pectus excavatum	The Catholic University of Korea	Unknown	No outcome recorded
Phase 4	NCT00528515	Feb 2007 → Mar 2008	coronary artery disorder	Medical University of Gdansk	Completed	No outcome recorded

Phase not applicable56 trials
—	NCT07511634	Apr → Dec 2026 expected	—	Pusan National University Yangsan Hospital	Not yet recruiting	No outcome recorded
—	NCT07295158	Mar → Jul 2026 overdue	—	Konya City Hospital	Recruiting	No outcome recorded
—	NCT07239479	Dec 2025 → Dec 2026 expected	colorectal neoplasm	Tam Anh Research Institute	Recruiting	No outcome recorded
—	NCT07271472	Dec 2025 → May 2026	—	Ataturk University	Completed	No outcome recorded
—	NCT07016308	Jun → Nov 2025	—	Harran University	Completed	No outcome recorded
—	NCT06772558	Feb → May 2025 overdue	avascular necrosis, benign prostatic hyperplasia, cholecystitis, coronary artery disorder +1	Xiaguang Duan	Not yet recruiting	No outcome recorded
—	NCT06759623	Jan 2025 → Apr 2026 overdue	obesity disorder	Medical University of Gdansk	Recruiting	No outcome recorded
—	NCT06252207	Dec 2023 → Mar 2026	—	The Cleveland Clinic	Withdrawn	No outcome recorded
—	NCT06123624	Nov 2023 → Aug 2024	spinal cord disorder	Ajou University School of Medicine	Unknown	No outcome recorded
—	NCT06207344	Oct 2023 → Dec 2024	—	The Second Affiliated Hospital of Chongqing Medical University	Unknown	No outcome recorded
—	NCT06176144	Sep 2023 → Jul 2025	delirium, subjective cognitive decline	West China Hospital	Unknown	No outcome recorded
—	NCT05866315	May → Sep 2023	—	Wonkwang University Hospital	Completed	No outcome recorded
—	NCT03763305	Jan → Dec 2023	—	Seoul National University Hospital	Withdrawn	No outcome recorded
—	NCT05550714	Oct 2022 → Mar 2024 overdue	Parkinson disease	Beijing Tiantan Hospital	Recruiting	No outcome recorded
—	NCT05465330	Jul 2022 → Apr 2023	prolonged electroretinal response suppression 2	Beijing Tiantan Hospital	Completed	No outcome recorded
—	NCT05185167	Jan → Mar 2022	DNA repair disease	Muğla Sıtkı Koçman University	Completed	No outcome recorded
—	NCT05088252	Dec 2021 → May 2022	pituitary tumor	Beijing Tiantan Hospital	Completed	No outcome recorded
—	NCT04805775	Oct 2021 → Sep 2022	breast neoplasm	Zhongnan Hospital	Completed	No outcome recorded
—	NCT04983966	Aug 2021 → Feb 2024	—	Gangnam Severance Hospital	Completed	No outcome recorded
—	NCT04691128	Jan → Aug 2021	supratentorial cancer	Beijing Tiantan Hospital	Completed	No outcome recorded
—	NCT04188314	Feb 2020 → Feb 2022	—	Sefako Makgatho Health Sciences University	Completed	No outcome recorded
—	NCT04077827	Sep 2019 → Mar 2020	breast cancer	National and Kapodistrian University of Athens	Completed	No outcome recorded
—	NCT03864276	Feb 2019 → Dec 2020	cirrhosis of liver	Yonsei University	Completed	No outcome recorded
—	NCT03587779	Jul 2018 → Jan 2019	—	Kangbuk Samsung Hospital	Completed	No outcome recorded
—	NCT03570164	Jun → Nov 2018	—	Kangbuk Samsung Hospital	Completed	No outcome recorded
—	NCT03259672	Oct 2017 → Oct 2018	—	Keimyung University Dongsan Medical Center	Unknown	No outcome recorded
—	NCT03447691	Aug 2017 → Aug 2022	digestive system carcinoma	Yonsei University	Unknown	No outcome recorded
—	NCT04036487	Jul 2017 → May 2018	—	Chih-Cheng Hung	Completed	No outcome recorded
—	NCT02909413	Oct 2016 → Oct 2019	—	Shengjing Hospital	Unknown	No outcome recorded
—	NCT02922660	Oct 2016 → Dec 2017	—	Xiaoliang Gan	Completed	No outcome recorded
—	NCT02916407	Sep 2016 → Nov 2017	entropion	Inje University	Completed	No outcome recorded
—	NCT03848780	Apr 2016 → Jun 2018	ischemic disease	Aristotle University Of Thessaloniki	Completed	No outcome recorded
—	NCT02470442	Jun 2015 → Feb 2016	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT02458547	May 2015 → Jan 2019	—	Yonsei University	Completed	No outcome recorded
—	NCT02617680	Feb → Dec 2015	—	University Hospital Hradec Kralove	Completed	No outcome recorded
—	NCT03860129	Dec 2014 → May 2017	—	Ruhr University of Bochum	Completed	No outcome recorded
—	NCT02643615	Sep 2014 → Mar 2016	optic nerve disorder	Ohio State University	Completed	No outcome recorded
—	NCT02342509	Sep → Dec 2014	—	Ruhr University of Bochum	Completed	No outcome recorded
—	NCT02191371	Jul → Dec 2014	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT02283866	Jun 2014 → Mar 2015	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT03029715	Feb 2014 → Mar 2016	obesity disorder	Menoufia University	Completed	No outcome recorded
—	NCT02520947	Jan → Oct 2014	—	Baskent University Ankara Hospital	Completed	No outcome recorded
—	NCT02003885	Jan 2014 → Aug 2015	heart valve disorder	Konkuk University Medical Center	Unknown	No outcome recorded
—	NCT02079064	Jan 2014 → Jun 2017	—	Theodor Bilharz Research Institute	Completed	No outcome recorded
—	NCT02410460	Sep 2013 → Jun 2014	—	Mercy Facial Plastic Surgery Center	Completed	No outcome recorded
—	NCT03100604	Aug 2013 → Mar 2016	ear malformation	Trakya University	Completed	No outcome recorded
—	NCT02199314	Mar 2013 → Apr 2016	idiopathic scoliosis	Children's Hospital Medical Center, Cincinnati	Completed	No outcome recorded
—	NCT01760018	Dec 2012 → Jan 2013	—	Yonsei University	Completed	No outcome recorded
—	NCT01443572	Sep 2011 → Jul 2014	biliary atresia	Yonsei University	Completed	No outcome recorded
—	NCT01436799	Mar → Aug 2011	brain ischemia	Gachon University Gil Medical Center	Completed	No outcome recorded
—	NCT01171833	Jun → Oct 2010	—	DongGuk University	Completed	No outcome recorded
—	NCT01235143	May 2010 → Aug 2012	urinary system disorder	Prince of Songkla University	Completed	No outcome recorded
—	NCT01083953	Nov 2009 → Jul 2010	—	University of Malaya	Completed	No outcome recorded
—	NCT00815269	Dec 2008 → Dec 2009	—	Nanjing Medical University	Completed	No outcome recorded
—	NCT00400790	Sep 2007 → Jan 2010	amnestic disorder, coronary artery disorder, delirium, dementia	University of Melbourne	Completed	No outcome recorded
—	NCT00434382	Oct 2002 → Dec 2003	—	Ludwig-Maximilians - University of Munich	Unknown	No outcome recorded

Also used as a comparator or background therapy in 86 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/21 trial
Phase 1/2	NCT01700907 Comparator	Aug 2012 → Feb 2013	—	Sapporo Medical University	Completed	No outcome recorded
Phase 24 trials
Phase 2	NCT05502458 Comparator	Dec 2020 → Aug 2022	hepatocellular carcinoma	Zhejiang Cancer Hospital	Completed	No outcome recorded
Phase 2	NCT02971254 Comparator	Dec 2016 → Jan 2019	Down syndrome	Asklepieion Voulas General Hospital	Completed	No outcome recorded
Phase 2	NCT03727607 Comparator	Jan 2016 → Dec 2017	obesity disorder	Ostfold Hospital Trust	Completed	No outcome recorded
Phase 2	NCT01696630 Comparator	Oct 2012 → Jul 2014	colorectal cancer	Centre Leon Berard	Completed	No outcome recorded
Phase 33 trials
Phase 3	NCT07289945 Comparator	Sep 2024 → Apr 2025	cognitive disorder	Hopital Charles Nicolle	Completed	No outcome recorded
Phase 3	NCT01219881 Comparator	Sep 2010 → Oct 2012	—	Ohio State University	Completed	No outcome recorded
Phase 3	NCT00219856 Comparator	Aug 2004 → Mar 2006	—	Rennes University Hospital	Completed	No outcome recorded
Phase 436 trials
Phase 4	NCT06457958 Comparator	Jun → Aug 2025	cholecystitis	Kocaeli City Hospital	Withdrawn	No outcome recorded
Phase 4	NCT06330038 Comparator	Aug 2024 → Dec 2028 expected	non-small cell lung carcinoma	Samsung Medical Center	Recruiting	No outcome recorded
Phase 4	NCT05172739 Comparator	Oct 2021 → Nov 2025 overdue	chronic pain syndrome, non-small cell lung carcinoma, substance-related disorder	University of Crete	Recruiting	No outcome recorded
Phase 4	NCT04717102 Comparator	Apr 2021 → Mar 2024	—	Changi General Hospital	Completed	No outcome recorded
Phase 4	NCT04894864 Comparator	Oct 2020 → Sep 2026 expected	abdominal aortic aneurysm	University of Crete	Recruiting	No outcome recorded
Phase 4	NCT04395248 Comparator	May 2020 → Aug 2021	obesity disorder	Taipei Medical University Shuang Ho Hospital	Completed	No outcome recorded
Phase 4	NCT04039854 Comparator	Nov 2019 → Nov 2021	coronary artery disorder	King's College Hospital NHS Trust	Unknown	No outcome recorded
Phase 4	NCT03729011 Comparator	Jan 2019 → Jan 2024	delirium	Meshalkin Research Institute of Pathology of Circulation	Completed	No outcome recorded
Phase 4	NCT03263117 Comparator	Jul 2018 → Apr 2023	stroke disorder	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 4	NCT03504033 Comparator	Apr 2018 → Sep 2019	—	RWTH Aachen University	Withdrawn	No outcome recorded
Phase 4	NCT03996148 Comparator	Sep 2017 → Sep 2018	carotid stenosis	The Cooper Health System	Completed	No outcome recorded
Phase 4	NCT03435003 Comparator	Aug 2017 → Mar 2019	—	Stony Brook University	Completed	No outcome recorded
Phase 4	NCT04074460 Comparator	Aug 2017 → Oct 2019	breast cancer, colorectal cancer, cutaneous melanoma, lung cancer +1	Peter MacCallum Cancer Centre, Australia	Completed	No outcome recorded
Phase 4	NCT03099616 Comparator	Apr 2017 → Dec 2019	—	Dr Nitin Sethi	Completed	No outcome recorded
Phase 4	NCT03540030 Comparator	Sep 2016 → Mar 2019	avascular necrosis, osteoarthritis, rotator cuff syndrome, substance-related disorder	OrthoCarolina Research Institute, Inc.	Completed	No outcome recorded
Phase 4	NCT02925611 Comparator	Jan 2016 → Mar 2017	delirium	Post Graduate Institute of Medical Education and Research, Chandigarh	Completed	No outcome recorded
Phase 4	NCT02987218 Comparator	Jul 2015 → Oct 2016	—	Post Graduate Institute of Medical Education and Research, Chandigarh	Completed	No outcome recorded
Phase 4	NCT04287842 Comparator	May 2015	cardiac arrest	Negovsky Reanimatology Research Institute	Withdrawn	No outcome recorded
Phase 4	NCT03417518 Comparator	Jan → Oct 2015	obesity disorder	Centre Hospitalier Universitaire Saint Pierre	Completed	No outcome recorded
Phase 4	NCT02379715 Background	Dec 2014 → May 2015	—	Ajou University School of Medicine	Completed	No outcome recorded
Phase 4	NCT02631525 Comparator	Aug 2014 → Dec 2015	—	Federal University of Minas Gerais	Completed	No outcome recorded
Phase 4	NCT02174575 Comparator	Jul 2014 → May 2023	cholangiocarcinoma, gallbladder neoplasm, hepatocellular carcinoma	Tokyo Medical and Dental University	Withdrawn	No outcome recorded
Phase 4	NCT02149628 Comparator	May 2014 → Feb 2015	prostate cancer	Yonsei University	Completed	No outcome recorded
Phase 4	NCT02379546 Background	Aug 2013 → May 2015	strabismus	Tokat Gaziosmanpasa University	Completed	No outcome recorded
Phase 4	NCT01924871 Comparator	Jul 2013 → Mar 2014	—	Chung-Ang University Hospital	Completed	No outcome recorded
Phase 4	NCT01878656 Comparator	Apr 2013 → Feb 2014	—	Chung-Ang University Hospital	Completed	No outcome recorded
Phase 4	NCT01833676 Comparator	Mar 2012 → Apr 2013	lung disorder	University of Malaya	Completed	No outcome recorded
Phase 4	NCT01310582 Comparator	May 2011 → Aug 2013	ureteral obstruction, urinary bladder disorder, urolithiasis, vaginal disorder	Hahnemann University Hospital	Completed	No outcome recorded
Phase 4	NCT01167803 Comparator	Dec 2010 → Nov 2012	obesity disorder	Nîmes University Hospital	Completed	No outcome recorded
Phase 4	NCT01270620 Comparator	Dec 2010 → Jul 2015	arthritic joint disease, obesity disorder	Pedro Paulo Tanaka	Completed	No outcome recorded
Phase 4	NCT01199237 Comparator	Aug 2010 → Aug 2012	—	University of California, San Francisco	Completed	No outcome recorded
Phase 4	NCT01125982 Comparator	Jun 2010 → Jul 2013	—	Sykehuset Telemark	Completed	No outcome recorded
Phase 4	NCT01132157 Comparator	Mar 2010 → Jan 2012	end stage renal failure	Yonsei University	Completed	No outcome recorded
Phase 4	NCT00446212 Comparator	Aug 2006 → Jul 2008	—	Melbourne Health	Completed	No outcome recorded
Phase 4	NCT00244517 Comparator	Jun 2004 → Apr 2010	cardiac ventricle disorder	University Hospital, Basel, Switzerland	Terminated	No outcome recorded
Phase 4	NCT04226625 Comparator	Jan 2000 → Mar 2001	—	Columbia University	Completed	No outcome recorded

Phase not applicable42 trials
—	NCT07525648 Comparator	Apr → May 2026	intracranial hypertension	Medipol University	Completed	No outcome recorded
—	NCT07440758 Comparator	Mar → Jul 2026 overdue	gallbladder disorder	Kayseri City Hospital	Recruiting	No outcome recorded
—	NCT07304479 Comparator	May 2025 → Jan 2026 overdue	—	National and Kapodistrian University of Athens	Recruiting	No outcome recorded
—	NCT07363681 Comparator	Oct 2024 → Feb 2026 overdue	nephrolithiasis	Bakirkoy Dr. Dr. Sadi Konuk Research and Training Hospital	Recruiting	No outcome recorded
—	NCT06387836 Comparator	Apr 2024 → May 2025	subjective cognitive decline	Shanghai Zhongshan Hospital	Completed	No outcome recorded
—	NCT07568938 Comparator	Jan 2024 → Feb 2027 expected	obesity disorder, substance-related disorder	G.Gennimatas General Hospital	Recruiting	No outcome recorded
—	NCT07337135 Background	Oct 2023 → Apr 2024	morbid obesity	Hospital dos Lusíadas	Completed	No outcome recorded
—	NCT05774366 Comparator	Mar → Dec 2023	—	Daegu Catholic University Medical Center	Unknown	No outcome recorded
—	NCT05557253 Comparator	Oct 2022 → Oct 2023	—	Seoul National University Hospital	Unknown	No outcome recorded
—	NCT05951686 Comparator	Aug 2022 → Oct 2023	—	Bozyaka Training and Research Hospital	Completed	No outcome recorded
—	NCT04775212 Comparator	Jun → Oct 2021	—	National Cancer Institute, Egypt	Unknown	No outcome recorded
—	NCT05414721 Comparator	May 2021 → Jan 2022	—	Yuzuncu Yil University	Completed	No outcome recorded
—	NCT04767503 Comparator	Feb 2021 → Sep 2022	liver and intrahepatic bile duct neoplasm	National Taiwan University Hospital	Completed	No outcome recorded
—	NCT04645316 Comparator	Nov 2020 → Jun 2021	lung disorder	Inonu University	Completed	No outcome recorded
—	NCT04503148 Comparator	Sep 2020 → Dec 2022 overdue	renal cell carcinoma	Seoul National University Hospital	Active not recruiting	No outcome recorded
—	NCT04474600 Comparator	Jul 2020 → Feb 2024	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT04447105 Comparator	Jun 2020 → Jul 2021	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT05148637 Comparator	Nov 2019 → Oct 2021	spinal cord disorder	Tanta University	Completed	No outcome recorded
—	NCT04104334 Comparator	May 2019 → Nov 2020	colorectal neoplasm	Ciusss de L'Est de l'Île de Montréal	Terminated	No outcome recorded
—	NCT03756961 Background	May 2019 → May 2028 expected	obesity disorder	Göteborg University	Recruiting	No outcome recorded
—	NCT03659539 Comparator	Sep 2018 → May 2023	—	Nitin Sethi, DNB	Completed	No outcome recorded
—	NCT03539003 Comparator	May 2018 → Jan 2019	—	Yonsei University	Completed	No outcome recorded
—	NCT03152981 Comparator	Jun → Dec 2017	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT02726620 Background	Jan → Dec 2017	hypotensive disorder	Vanderbilt University Medical Center	Completed	No outcome recorded
—	NCT03016234 Comparator	Sep 2016 → Mar 2017	—	Saint Vincent's Hospital, Korea	Completed	No outcome recorded
—	NCT02826902 Comparator	Sep 2016 → Nov 2019	isolated short stature, osteoarthritis	Yonsei University	Completed	No outcome recorded
—	NCT02625181 Background	Jul 2016 → Nov 2017	—	Vanderbilt University	Completed	No outcome recorded
—	NCT02756715 Comparator	May 2016 → Mar 2018	ischemic disease	Konkuk University Medical Center	Completed	No outcome recorded
—	NCT02709863 Comparator	Oct 2015 → Feb 2017	pituitary gland adenoma	Istanbul University	Unknown	No outcome recorded
—	NCT02515968 Comparator	Aug → Sep 2015	—	Yonsei University	Withdrawn	No outcome recorded
—	NCT02406300 Comparator	Apr 2015 → Dec 2016	bone disorder	Centro Hospitalar do Porto	Terminated	No outcome recorded
—	NCT02212340 Comparator	Jul 2014 → Jan 2016	—	Yonsei University	Completed	No outcome recorded
—	NCT02096224 Comparator	May → Jul 2014	urinary bladder neoplasm	Seoul National University Hospital	Completed	No outcome recorded
—	NCT02412150 Background	Apr 2014 → Nov 2020	thyroid tumor	Chosun University Hospital	Completed	No outcome recorded
—	NCT02003768 Comparator	Oct 2013 → Jun 2015	optic nerve disorder	Yonsei University	Withdrawn	No outcome recorded
—	NCT04238806 Comparator	Sep 2013 → Aug 2014	—	Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital	Completed	No outcome recorded
—	NCT01937104 Background	Sep 2013 → Sep 2014	cervical cancer, cholecystitis, leiomyoma, ovarian cancer +1	Chosun University Hospital	Completed	No outcome recorded
—	NCT02324283 Comparator	Oct 2012 → Jun 2016	lung cancer	Juntendo University	Unknown	No outcome recorded
—	NCT01549873 Comparator	Jan 2012 → Apr 2013	idiopathic scoliosis	Nationwide Children's Hospital	Completed	No outcome recorded
—	NCT01936545 Comparator	May 2011 → Dec 2015	acute lung injury	National Taiwan University Hospital	Unknown	No outcome recorded
—	NCT01202162 Comparator	Feb 2010 → Mar 2012	—	Northwestern University	Completed	No outcome recorded
—	NCT00983918 Comparator	Sep 2009 → Jun 2010	—	Baylor College of Medicine	Completed	No outcome recorded

Evidence & citations 17 cited values

Every value below carries the sentence it was read from. 181 sources stand behind the page.

Field	Value	Cited text
Known as	desflurane	“The GAS group will receive one or more volatile anesthetics (sevoflurane, desflurane, or isoflurane) for induction and maintenance of anesthesia during the surgery.” NCT06330038 ↗ 181 “During the operation, patients are treated with remifentanil, cisatracurium, and desflurane inhalation at 0.5-1.0 minimum alveolar concentration (MAC).” NCT05550714 ↗ “During maintenance, desflurane 5-7% (MAC 1-1.3) and TCI remifentanil at a Ce of 1.5-3 ng/mL will be administered, targeting a BIS value between 40-60.” NCT07271472 ↗ “if inhalational maintenance of anesthesia is used it will be achieved with sevoflurane 1% to 2% or desflurane 3% to 6% end-tidal concentration” NCT03263117 ↗ “General anesthesia for patients will be inducted and maintained with desflurane inhalation and remifentanil infusion.” NCT04983966 ↗ “Patients will be randomized to Sevoflurane or Desflurane as the single volatile anesthetics for general anesthesia.” NCT04395248 ↗ “Maintenance of general anesthesia with volatile agent (sevoflurane, desflurane, or isoflurane)” NCT03034096 ↗ “Patients undergoing anesthesia for bariatric surgery with desflurane as a volatile agent.” NCT06759623 ↗ “The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane.” NCT02909413 ↗ “Desflurane , introduced into clinical practice in 1990 as an inhaled anesthetic” NCT07116733 ↗ “Sevoflurane or desflurane for induction and maintenance of anesthesia” NCT04503148 ↗ “Anesthesia maintenance: Desflurane set at approximately 1 MAC” NCT04894864 ↗ “Anesthesia maintenance: Desflurane 6-8 vol%” NCT05557253 ↗ “Desflurane, Morphine, Paracetamol” NCT05172739 ↗ “volatile anesthesia (desflurane)” NCT04077827 ↗ “* Desflurane for maintenance,” NCT07337135 ↗ “OFA with Desflurane” NCT07568938 ↗ “Desflurane” NCT07568938 ↗ NCT01870011 ↗ NCT02213718 ↗ NCT05148637 ↗ NCT03540030 ↗ NCT07525648 ↗ NCT03756961 ↗ NCT03447691 ↗ NCT02717780 ↗ NCT07239479 ↗ NCT03194074 ↗ NCT00983918 ↗ NCT03539003 ↗ NCT07363681 ↗ NCT03618082 ↗ NCT02504138 ↗ NCT05088252 ↗ NCT05774366 ↗ NCT04541823 ↗ NCT01083953 ↗ NCT03763305 ↗ NCT02283866 ↗ NCT03587779 ↗ NCT01886664 ↗ NCT00815269 ↗ NCT04036487 ↗ NCT01235143 ↗ NCT02726620 ↗ NCT00528515 ↗ NCT01270620 ↗ NCT04775212 ↗ NCT07359508 ↗ NCT04104334 ↗ NCT02925611 ↗ NCT02199314 ↗ NCT01132157 ↗ NCT04771962 ↗ NCT01219881 ↗ NCT04983966 ↗ NCT00762372 ↗ NCT01486953 ↗ NCT02019797 ↗ NCT03029715 ↗ NCT04188314 ↗ NCT05185167 ↗ NCT03006250 ↗ NCT02625181 ↗ NCT02191371 ↗ NCT03570164 ↗ NCT07304479 ↗ NCT06457958 ↗ NCT02105610 ↗ NCT04039854 ↗ NCT02515968 ↗ NCT03099616 ↗ NCT02922660 ↗ NCT01937104 ↗ NCT02412150 ↗ NCT01936545 ↗ NCT04074460 ↗ NCT03100604 ↗ NCT06241131 ↗ NCT03209193 ↗ NCT03016234 ↗ NCT04447105 ↗ NCT02756715 ↗ NCT06176144 ↗ NCT02826902 ↗ NCT04691128 ↗ NCT02830243 ↗ NCT05246371 ↗ NCT07295158 ↗ NCT01436799 ↗ NCT02916407 ↗ NCT02617680 ↗ NCT02342509 ↗ NCT02410460 ↗ NCT03864276 ↗ NCT05502458 ↗ NCT07016308 ↗ NCT02971254 ↗ NCT04767503 ↗ NCT02520947 ↗ NCT02458547 ↗ NCT03417518 ↗ NCT07511634 ↗ NCT04226625 ↗ NCT01696630 ↗ NCT04805775 ↗ NCT02212340 ↗ NCT02834845 ↗ NCT05951686 ↗ NCT01199237 ↗ NCT06207344 ↗ NCT01985854 ↗ NCT03435003 ↗ NCT03504033 ↗ NCT05331027 ↗ NCT01171833 ↗ NCT02406300 ↗ NCT07289945 ↗ NCT02631525 ↗ NCT03727607 ↗ NCT02609802 ↗ NCT06387836 ↗ NCT03860129 ↗ NCT05414721 ↗ NCT00219856 ↗ NCT00434382 ↗ NCT04238806 ↗ NCT01549873 ↗ NCT01700907 ↗ NCT02987218 ↗ NCT00244517 ↗ NCT04474600 ↗ NCT02335151 ↗ NCT01167803 ↗ NCT06772558 ↗ NCT02698514 ↗ NCT03917186 ↗ NCT05990790 ↗ NCT01125982 ↗ NCT05866315 ↗ NCT02096224 ↗ NCT01202162 ↗ NCT06123624 ↗ NCT01443572 ↗ NCT01833676 ↗ NCT01878656 ↗ NCT05783518 ↗ NCT01924871 ↗ NCT04717102 ↗ NCT00400790 ↗ NCT02643615 ↗ NCT01310582 ↗ NCT05465330 ↗ NCT02470442 ↗ NCT01760018 ↗ NCT02149628 ↗ NCT02003768 ↗ NCT04287842 ↗ NCT07123870 ↗ NCT03659539 ↗ NCT04645316 ↗ NCT02079064 ↗ NCT02003885 ↗ NCT02559297 ↗ NCT03848780 ↗ NCT02872389 ↗ NCT00446212 ↗ NCT06252207 ↗ NCT03152981 ↗ NCT02174575 ↗ NCT02324283 ↗ NCT03996148 ↗ NCT02036736 ↗ NCT03259672 ↗ NCT02709863 ↗ NCT01452256 ↗ NCT06779890 ↗ NCT07440758 ↗ NCT02322502 ↗ NCT03729011 ↗ NCT02379546 ↗ NCT02379715 ↗
Known as	desflurane (Suprane(R), Baxter Healthcare)	“desflurane (Suprane(R), Baxter Healthcare)” NCT02191371 ↗
Known as	Desflurano	ChEMBL registry synonym — accepted as the source's own label CHEMBL1200733 ↗
Known as	I-653	ChEMBL registry synonym — accepted as the source's own label CHEMBL1200733 ↗
Known as	Suprane	ChEMBL registry synonym — accepted as the source's own label CHEMBL1200733 ↗
Known as	Suprane (desflurane, USP)	“Suprane (desflurane, USP)” NCT01235143 ↗
Action	Activate	“Potassium channel subfamily K member 18 opener” CHEMBL1200733 ↗ 4 “Potassium channel subfamily K member 10 opener” CHEMBL1200733 ↗ “Potassium channel subfamily K member 9 opener” CHEMBL1200733 ↗ “Potassium channel subfamily K member 3 opener” CHEMBL1200733 ↗ “Potassium channel subfamily K member 2 opener” CHEMBL1200733 ↗
Action	Inhibit	“The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.” NCT02096224 ↗
Modality	Other / unclassified	“Desflurane is the new volatile anesthetic agent” NCT01235143 ↗
Route	Inhaled	“Inhaled desflurane aiming an alveolar concentration of 4 to 6 per cent.” NCT00219856 ↗
Target	CDC42	“by modulating Cdc42 and Clock proteins” NCT06772558 ↗
Target	CLOCK	“by modulating Cdc42 and Clock proteins” NCT06772558 ↗
Target	KCNK10	“Potassium channel subfamily K member 10 opener” CHEMBL1200733 ↗
Target	KCNK18	“Potassium channel subfamily K member 18 opener” CHEMBL1200733 ↗
Target	KCNK2	“Potassium channel subfamily K member 2 opener” CHEMBL1200733 ↗
Target	KCNK3	“Potassium channel subfamily K member 3 opener” CHEMBL1200733 ↗
Target	KCNK9	“Potassium channel subfamily K member 9 opener” CHEMBL1200733 ↗