Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics

Withdrawn Seoul National University Hospital

RandomizedParallel-groupTriple-blindOther

Summary

Skin sympathetic nerve activity (SKNA) has recently been discovered from the electrocardiogram obtained from healthy volunteers. The raw physiologic electric signal from electrodes placed on the skin was reprocessed through filtering and integration using software to produce the SKNA signal. However, no study has yet provided knowledge on the effect of anesthetics on SKNA during general anesthesia.

Timeline

Start: 2023-01-01
Primary completion: 2023-12-31
Completion: 2023-12-31

Outcome

Outcome not reported

Stopped: “Devices for measuring SKNA are need to be re-constructed, which takes considerable time.”

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Desflurane	Other / unclassified	1 unknown	Inhaled
Subject	Fentanyl	Other / unclassified	1 ug/kg	Intravenous
Subject	Propofol	Small molecule	3 ug/ml	Intravenous
Subject	Propofol	Small molecule	5 ug/ml	Intravenous
Subject	Propofol	Small molecule	1.5 mg/kg	Intravenous
Subject	Propofol	Small molecule	2 mg/kg	Intravenous
Subject	Remifentanil	Small molecule	3 ng/ml	Intravenous
Subject	Remifentanil	Small molecule	5 ng/ml	Intravenous
Subject	Sevoflurane	Other / unclassified	1 unknown	Inhaled

Indications

No indication recorded.