drugset / Trial / NCT07568938
Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
Recruiting
70 enrolled
G.Gennimatas General Hospital
National and Kapodistrian University of Athens · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer : -Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane? Participants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.
Timeline
- Start
- 2024-01-10
- Primary completion
- 2027-02-28
- Completion
- 2027-05-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Desflurane | Other / unclassified | — | Inhaled |
| Comparator | Propofol | Small molecule | — | — |
| Comparator | Acetaminophen | Small molecule | 1000 mg | — |
| Comparator | Dexamethasone | Small molecule | 8 mg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 1 ug/kg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 50 ug | — |
| Comparator | Fentanyl | Other / unclassified | 1 ug/kg | — |
| Comparator | Ketamine | Small molecule | 0.3 mg/kg | — |
| Comparator | Ketamine | Small molecule | 50 mg | — |
| Comparator | Lidocaine | Other / unclassified | 500 mg | — |
| Comparator | Magnesium Sulfate | Other / unclassified | 40 mg/kg | — |
| Comparator | Ondansetron | Other / unclassified | 4 mg | — |
| Comparator | Parecoxib | Small molecule | 40 mg | — |
| Comparator | Rocuronium | Other / unclassified | — | — |
| Comparator | Tramadol | Other / unclassified | 100 mg | — |